A5025123492- Autopsy Techniques and Outcomes
- COVID-19 and healthcare impacts
- Acute Lymphoblastic Leukemia research
- COVID-19 Clinical Research Studies
- Climate Change and Health Impacts
- Urbanization and City Planning
- COVID-19 diagnosis using AI
- Healthcare cost, quality, practices
- Long-Term Effects of COVID-19
- Histiocytic Disorders and Treatments
- Spine and Intervertebral Disc Pathology
- Pelvic and Acetabular Injuries
- Anatomy and Medical Technology
- Pharmaceutical studies and practices
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immunodeficiency and Autoimmune Disorders
- SARS-CoV-2 detection and testing
- Viral-associated cancers and disorders
- Poisoning and overdose treatments
- Adolescent and Pediatric Healthcare
- Spinal Fractures and Fixation Techniques
- Automotive and Human Injury Biomechanics
- Artificial Intelligence in Healthcare and Education
- Blood disorders and treatments
- Craniofacial Disorders and Treatments
University Medical Center Hamburg-Eppendorf
2021-2023
Universität Hamburg
2021-2023
RWTH Aachen University
2022
Hamburg University of Technology
2021
Carl-Thiem-Klinikum Cottbus
1992-2007
University of Göttingen
1994
Autopsies are an important tool in medicine, dissecting disease pathophysiology and causes of death. In COVID-19, autopsies revealed e.g., the effects on pulmonary (micro)vasculature or nervous system, systemic viral spread, interplay with immune system. To facilitate multicentre autopsy-based studies provide a central hub supporting autopsy centres, researchers, data analyses reporting, April 2020 German COVID-19 Autopsy Registry (DeRegCOVID) was launched. The electronic registry uses...
In severe cases, SARS-CoV-2 infection leads to acute respiratory distress syndrome (ARDS), often treated by extracorporeal membrane oxygenation (ECMO). During ECMO therapy, anticoagulation is crucial prevent device-associated thrombosis and device failure, however, it associated with bleeding complications. COVID-19, additional pathologies, such as endotheliitis, may further increase the risk of To assess frequency events, we analyzed data from German COVID-19 autopsy registry (DeRegCOVID).
Diagnosing traumatic brain injury (TBI) from body fluids in cases where there are no obvious external signs of impact would be useful for emergency physicians and forensic pathologists alike. None the previous attempts has so far succeeded establishing a single biomarker to reliably detect TBI with regards sensitivity: specificity ratio post mortem setting. This study investigated combination fluid biomarkers (obtained mortem), which may step towards increasing accuracy biochemical...
Abstract Due to the development of novel functionalities, distinct SARS-CoV-2 variants such as B.1.1.7 fuel current pandemic. is not only more transmissible, but may also cause an increased mortality compared previous variants. Human tissue analysis lineage urgently needed, and we here present autopsy data from 7 consecutive cases. The initial RT-qPCR analyses nasopharyngeal swabs taken post mortem included typing assays for B.1.1.7. We quantitated viral load in multiple organs. Highest...
In pathology and legal medicine, the histopathological microbiological analysis of tissue samples from infected deceased is a valuable information for developing treatment strategies during pandemic such as COVID-19. However, conventional autopsy carries risk disease transmission may be rejected by relatives. We propose minimally invasive biopsy with robot assistance under CT guidance to minimize sampling improve accuracy. A flexible robotic system presented, which applied human corpses...
The alteration in mechanical properties of posterior pelvis ligaments may cause a biased deformation which, turn, contribute to hip and spine instability malfunction. Here, the effect different on lumbopelvic is analyzed via finite element method. First, improved model was validated using experimental data from previous studies then used calculate sensitivity changes ligament properties, load magnitude, unilateral resection. complex relative given predominant medial plane. resection appeared...
Abstract In pandemics or to further study highly contagious infectious diseases, new strategies are needed for the collection of post-mortem tissue samples identify pathogen as well its morphological impact. this study, an ultrasound-guided minimally invasive sampling (MITS) protocol was developed and validated use. The histological microbiological qualities specimens were evaluated compared between MITS conventional autopsy (CA) in a series COVID-19 deaths. Thirty-six performed. five cases...
Abstract Understanding the underlying pathology in different tissues and organs is crucial when fighting pandemics like COVID-19. During conventional autopsy, large tissue sample sets of multiple can be collected from cadavers. However, direct contact with an infectious corpse associated risk disease transmission relatives deceased might object to a autopsy. To overcome these drawbacks, we consider minimally invasive autopsies robotic needle placement as practical alternative. One challenge...
Between September and August 1991 818 previously untreated children adolescents up to 18 years of age with acute lymphoblastic leukemia were entered into two modified BFM-protocols. Patients B-ALL excluded. From 1981 1987 524 patients the randomized multicenter study ALL VII/81 (modified ALL-BFM 81 protocol). divided three risk groups standard (SR), medium (MR), high (HR) using BFM factor. In a connecting from 1988 294 registered on stratified multicentric trial VIII/87 86 study). The main...
Between 1988 and 1990, 55 patients with first relapses of acute lymphoblastic leukemia (ALL) were treated a modified BFM-protocol (ALL REZ 1/88). The divided according to time site relapse: bone marrow involvement up 6 months after stopping front line therapy (group A), beyond month B) isolated extramedullary at any C). During the received alternating courses polychemotherapy including infusions intermediate dose methotrexate (1 g/m2 in 36 hours). maintenance treatment consisted daily oral...
Abstract Acute liver failure (ALF) is a rare and unexpected condition, which commonly related to drug ingestion viral infections. Here, two ALF fatalities are presented, showed rapid progression between the onset of symptoms death. Both cases gained attention as unusual substances were suspected be reason for fatal ALF, namely prescription-free natural remedy Iberogast® (Bayer Vital GmbH, Leverkusen, Germany) freely available energy drinks. Autopsy findings revealed that ALFs unrelated these...
In the past years number of hospital autopsies have declined steadily, becoming almost excluded from medical training. Medicolegal (forensic) account for all autopsies, whereas are increasingly rare. Minimally invasive tissue sampling (MITS) using post mortem ultrasound offers opportunity to increase examinations in a clinical and even forensic context. MITS is needle-based procedure that uses (radiological) imaging techniques examine major organs body, acquire samples aspirate fluid body...
Einleitung: Die Langerhans-Zell-Histiocytosis (LCH) stellt ein sehr seltenes Krankheitsbild dar. genaue Inzidenz und Prävalenz der Erkrankung sind unbekannt. Das Rauchen eine mögliche Hauptursache primär pulmonale Histiocytosis X ist im Erwachsenenalter. In dem beschriebenen Fall handelt es sich um rasch progressive, disseminierte Form (Abt-Lettlerer-Siwe-Erkrankung), die überwiegend Kleinkindalter auftritt.
Abstract Background Coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic with significant mortality. Accurate information on the specific circumstances of death and whether patients died from or SARS-CoV-2 is scarce. Methods To distinguish COVID-19 non-COVID-19 deaths, we performed systematic review 735 SARS-CoV-2-associated deaths in Hamburg, Germany, March to December 2020, using conventional autopsy,...