A5047922322- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Advanced X-ray and CT Imaging
- Advanced MRI Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiovascular Disease and Adiposity
- Radiation Dose and Imaging
- Transplantation: Methods and Outcomes
- Advanced Radiotherapy Techniques
- Cardiac Structural Anomalies and Repair
- Anatomy and Medical Technology
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Effects of Exercise
- Acute Myocardial Infarction Research
- Infective Endocarditis Diagnosis and Management
- Viral Infections and Immunology Research
- Cardiac pacing and defibrillation studies
- Mechanical Circulatory Support Devices
- Surgical Simulation and Training
- Renal Transplantation Outcomes and Treatments
- Coronary Interventions and Diagnostics
- Radiation Therapy and Dosimetry
- HIV-related health complications and treatments
Liverpool Hospital
2015-2024
UNSW Sydney
2013-2024
South Western Sydney Local Health District
2016-2024
St Vincent's Hospital Sydney
2008-2024
Victor Chang Cardiac Research Institute
2012-2024
Monash Health
2024
Monash University
2024
St Vincent’s Private Hospital Sydney
2024
Flinders University
2024
St Vincent's Clinic
2021-2023
T1 mapping is a robust and highly reproducible application to quantify myocardial relaxation of longitudinal magnetisation. Available methods are presently site vendor specific, with variable accuracy precision values between the systems sequences. We assessed transferability method determined reference healthy human myocardium in multicenter setting.
Advances of cardiac computed tomography angiography (CTA) have been developed for dose reduction, but their efficacy in clinical practice is largely unknown. This study was designed to evaluate radiation exposure and utilization dose-saving strategies contrast-enhanced CTA daily practice. Sixty one hospitals from 32 countries prospectively enrolled 4502 patients undergoing during calendar month 2017. Computed scan data images were analysed a central core lab compared with similar survey...
Abstract Background and Aims The detection of cancer therapy-related cardiac dysfunction (CTRCD) by reduction left ventricular ejection fraction (LVEF) during chemotherapy usually triggers the initiation cardioprotective therapy. This study addressed whether same approach should be applied to patients with worsening global longitudinal strain (GLS) without attaining thresholds LVEF. Methods Strain surveillance for improving cardiovascular outcomes (SUCCOUR-MRI) was a prospective multicentre...
Radiotherapy for thoracic and breast tumours is associated with a range of cardiotoxicities. Emerging evidence suggests cardiac substructure doses may be more predictive specific outcomes, however, quantitative data necessary to develop clinical planning constraints lacking. Retrospective analysis patient required, which relies on accurate segmentation substructures. In this study, novel model was designed deliver reliable, accurate, anatomically consistent 18 substructures computed...
Toxicity to cardiac and coronary structures is an important late morbidity for patients undergoing left-sided breast radiotherapy. Many current studies have relied on estimates of doses assuming standardised anatomy, with a calculated increase in relative risk 7.4% per Gy (mean heart dose). To provide individualised dose, delineation various patient images required. Automatic multi-atlas based segmentation can consistent, robust solution, however there are challenges this method. We aiming...
The aim of this study was to determine the contribution pre-load and heart rate pump flow in patients implanted with continuous-flow left ventricular assist devices (cfLVADs).Although it is known that cfLVAD increases exercise, unclear if increment driven by increased rate, augmented intrinsic contraction, or enhanced venous return.Two studies were performed HeartWare HVAD. In 11 patients, paced approximately 40 beats/min above baseline then down 30 below pacing (in pacemaker-dependent...
Abstract The aim of this article is to describe a novel hardware perfusion phantom that simulates myocardial first‐pass allowing comparisons between different MR techniques and validation the results against true gold standard. images were acquired at rates variable doses gadolinium cardiac output. system proved be sensitive controlled variations rate, contrast agent dose, It produced distinct signal intensity curves for ranging from 1 10 mL/mL/min. Quantification blood flow by deconvolution...
Body surface area (BSA) is the most commonly used metric for body size indexation of echocardiographic measures, but its use in patients who are underweight or obese questioned (body mass index (BMI) < 18.5 kg/m2 ≥ 30 kg/m2, respectively). We aim to survival analysis identify an optimal measures that would be a better predictor than BSA regardless BMI. Adult with no prior valve replacement were selected from National Echocardiography Database Australia. Survival was performed both unindexed...
Delineation variations and organ motion produce difficult-to-quantify uncertainties in planned radiation doses to targets organs at risk. Similar manual contouring, most automatic segmentation tools generate single delineations per structure; however, this does not indicate the range of clinically acceptable delineations. This study develops a method cardiac structure segmentations, incorporating delineation uncertainty, evaluates dosimetric impact lung cancer.
Background Subclinical left ventricular dysfunction detected by 2-dimensional global longitudinal strain post breast radiotherapy has been described in patients with cancer. We hypothesized that postradiotherapy may be site specific, based on differential segmental dose received. Methods and Results Transthoracic echocardiograms were performed at baseline, 6 weeks, 12 months 61 chemotherapy-naïve women left-sided cancer undergoing tangential radiotherapy. Radiation received within basal,...
Background: The prognostic value of cardiac magnetic resonance (CMR) derived left atrial (LA) strain, ejection fraction (LAEF) and indexed volumes (LAVImax LAVImin) after ST-elevation myocardial infarction (STEMI) remains controversial. aim this study was to assess the relationship between LA function major adverse cardiovascular events (MACE) STEMI.Methods: A total 202 prospectively recruited patients who underwent CMR at median day 4 STEMI had complete data for feature tracking assessment....