A5059756974- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer Treatment and Pharmacology
- Takotsubo Cardiomyopathy and Associated Phenomena
- Advanced MRI Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Heart Failure Treatment and Management
- Cardiovascular Health and Disease Prevention
- Heart Rate Variability and Autonomic Control
- Polymer Nanocomposite Synthesis and Irradiation
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular Disease and Adiposity
- Electron Spin Resonance Studies
- Cardiac pacing and defibrillation studies
- Blood Pressure and Hypertension Studies
- Optical Imaging and Spectroscopy Techniques
- Sarcoidosis and Beryllium Toxicity Research
- Pericarditis and Cardiac Tamponade
- Nitric Oxide and Endothelin Effects
- Nail Diseases and Treatments
- Diabetes Treatment and Management
- Forecasting Techniques and Applications
- Bone and Joint Diseases
- Analytical Methods in Pharmaceuticals
University of Tasmania
2015-2024
The University of Sydney
2019-2024
Nepean Hospital
2019-2024
Princess Alexandra Hospital
2024
Hunter Medical Research Institute
2024
Hunter New England Local Health District
2024
Menzies School of Health Research
2014-2023
WaterNSW
2022
Menzies Institute for Medical Research
2015-2021
Baker Heart and Diabetes Institute
2018
The variability of ejection fraction (EF) poses a problem in the assessment left ventricular (LV) function patients receiving potentially cardiotoxic chemotherapy. We sought to use global longitudinal strain (GLS) compare LV responses various chemotherapy regimens and examine response cardioprotection with beta-blockers (BB) showing subclinical myocardial damage.We studied 159 (49 ± 14 year, 127 women) anthracycline (group A, n = 53, 46 17 year), trastuzumab T, 61, 53 12 or after...
Abstract Background and Aims The detection of cancer therapy-related cardiac dysfunction (CTRCD) by reduction left ventricular ejection fraction (LVEF) during chemotherapy usually triggers the initiation cardioprotective therapy. This study addressed whether same approach should be applied to patients with worsening global longitudinal strain (GLS) without attaining thresholds LVEF. Methods Strain surveillance for improving cardiovascular outcomes (SUCCOUR-MRI) was a prospective multicentre...
Abstract BACKGROUND Central blood pressure (CBP) independently predicts cardiovascular risk, but calibration methods may affect accuracy of central systolic (CSBP). Standard (Stan-CSBP) from peripheral waveforms is usually derived with using brachial SBP and diastolic BP (DBP). However, oscillometric mean arterial (MAP) DBP (MAP-CSBP) purported to provide more accurate representation true invasive CSBP. This study sought determine which CSBP could accurately discriminate cardiac structural...
To assess the effects of frame and volume rate on concordance between two-dimensional speckle tracking strain (2DS) three-dimensional (3DS), 2DS triplane imaging (Tri-P).Global longitudinal strains (GLSs) derived from 2DS, 3DS, Tri-P were compared among 142 prospectively recruited patients who underwent evaluation subclinical left ventricle (LV) function.Feasibility to obtain GLS 3DS was significantly higher than that (76% vs. 47%, P < 0.001). The correlation only modest (r = 0.47) whereas...
AimsLeft atrial (LA) function helps to preserve cardiac output and control pulmonary capillary wedge pressure in the setting of left ventricular (LV) impairment, but little is known about contribution LA arrhythmia. We sought whether booster pump was associated with arrhythmias patients undergoing primary prevention implantable cardioverter-defibrillator (ICD) implantation for non-ischaemic dilated cardiomyopathy (NICM), independent global longitudinal strain (GLS) mechanical dispersion (MD).
The load dependence of global longitudinal strain (GLS) means that changes in systolic blood pressure (BP) between visits may confound the diagnosis cancer-treatment-related cardiac dysfunction (CTRCD). We sought to determine whether estimation myocardial work, which incorporates SBP, could overcome this limitation. In case-control study, 44 asymptomatic patients at risk CTRCD underwent echocardiography baseline and after oncologic treatment. was defined on basis change ejection fraction....
While echocardiographic grading of left ventricular (LV) diastolic dysfunction (DD) is used every day, the relationship between DD grade and hemodynamic abnormalities uncertain.We identified 460 consecutive patients who underwent transthoracic echocardiography within 24 h elective heart catheterization had: normal sinus rhythm, no confounding structural disease, change in medications echo, complete data. Patients were grouped based on grade. Hemodynamic tracings to determine time constant...