A5069659219- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiac electrophysiology and arrhythmias
- Heart Failure Treatment and Management
- Cardiac pacing and defibrillation studies
- Cardiovascular Disease and Adiposity
- SARS-CoV-2 and COVID-19 Research
- Vascular Procedures and Complications
- Mechanical Circulatory Support Devices
- COVID-19 Clinical Research Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Peripheral Artery Disease Management
- Cardiac Arrest and Resuscitation
- Aortic Disease and Treatment Approaches
- Cardiovascular and Diving-Related Complications
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Syncope and Autonomic Disorders
- Sepsis Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
Masaryk University
2012-2024
University Hospital Brno
2013-2024
Onze Lieve Vrouwziekenhuis Hospital
2016-2018
Abstract Background and Aims Circulating proenkephalin (PENK) is a stable endogenous polypeptide with fast response to glomerular dysfunction tubular damage. This study examined the predictive value of PENK for renal outcomes mortality in patients acute coronary syndromes (ACS). Methods Proenkephalin was measured plasma prospective multicentre ACS cohort from Switzerland (n=4787) validation cohorts UK (n=1141), Czechia (n=927), Germany (n=220). A biomarker-enhanced risk score (KID-ACS score)...
Septic shock is a major cause of mortality in ICU patients, its pathophysiology complex and not properly understood. Oxidative stress seems to be one the most important mechanisms progression multiple organ failure. In present pilot study, we have analysed eight oxidative-stress-related biomarkers seven consecutive time points (i.e., first days) 21 septic patients admitted ICU. Our objective was describe kinetics four related pro-oxidative processes (nitrite/nitrate, malondialdehyde,...
Abstract Background Older age, as a factor we cannot affect, is consistently one of the main negative prognostic values in patients with acute myocardial infarction. One most powerful factors that improves outcomes coronary syndromes revascularization preferably performed by percutaneous intervention. No data currently available for role age large groups consecutive PCI nearly sole method AMI patients. The aim this study was to analyze age-related differences treatment strategies, results...
To compare the outcomes of MitraClip versus minimally invasive surgical mitral valve repair in high-risk patients with significant functional regurgitation (FMR) and severe heart failure a centre having pilot extensive experience approach, respectively. The group consisted 24 high-surgical-risk [age 75 ± 9 years, 75% males, NYHA III/IV 88%, left ventricular (LV) ejection fraction 31 9%, EuroSCORE II 18 14%], while 48 matched for age, class LV fraction. Patients undergoing those showed higher...
Indirect evidences in reviews and case reports on Takotsubo syndrome (TTS) support the fact that existence of oxidative stress (OS) might be its common feature pre-acute stage. The sources OS are exogenous (environmental factors including pharmacological toxic influences) endogenous, combination both may present, they being discussed detail. is associated with several pathological conditions representing TTS comorbidities triggers. dominant source electrones mitochondria. Our analysis drug...
Heart failure (HF) patients are at higher risk of severe coronavirus disease 2019 (COVID-19). The Omicron variant has many novel mutations including those in the spike protein, leading to questions about vaccine effectiveness. aim this analysis was evaluate effectiveness COVID-19 with or without a booster (i.e., after third dose) during wave.Chronic heart Czech Republic were included analysis. infection monitored from January 1st 2022 March 31st 2022. conducted on data collected National...
Objectives. To assess the relation between initial ECG findings, presence of risk factors, coronary angiography and clinical outcomes in patients with acute myocardial infarction complicated by cardiogenic shock (CS). Design. Data from a total 5572 admitted to four tertiary hospitals during period 3 years were analyzed. CS on admission was present 358 (6.4%). They divided into groups based ECG: ST-segment elevation (STEMI), depression (STDMI), bundle branch block (BBBMI), other infarction....
Transradial catheterization (TRC) is a dominant access site for coronary and percutaneous interventions (PCI) in many centers. Previous studies reported higher intimal thickness of the radial artery (RA) wall patients with previous history TRC. In this investigation aim was to assess changes RA using optical coherence tomography (OCT) intravascular imaging serial manner.100 diagnosis non-ST-elevation myocardial infarction (nSTEMI) treated by PCI were enrolled (6 excluded from analysis...
Background The identification of high-risk heart failure (HF) patients makes it possible to intensify their treatment. Our aim was determine the prognostic value a newly developed, high-sensitivity troponin I assay (Atellica ® , Siemens Healthcare Diagnostics) for with HF reduced ejection fraction (HFrEF; LVEF < 40%) and mid-range EF (HFmrEF) (LVEF 40%–49%). Methods results A total 520 HFrEF HFmrEF were enrolled in this study. Two-year all-cause mortality, transplantation, and/or left...
Abstract Aims Identification of heart failure (HF) patients with secondary mitral regurgitation (SMR) that benefit from valve (MV) repair remains challenging. We have focused on the role left ventricular global longitudinal strain (LV‐GLS) and reservoir atrial (LASr) for prediction long‐term survival reverse remodelling in SMR undergoing endoscopic MV repair. Methods results The study population consisted 110 (age 67 ± 11 years, 66% men) symptomatic isolated using a minimally invasive...
Nowadays, optical coherent tomography (OCT) as the most precise morphologic technique is used in increasing number of cases, both routine clinical situations and research projects.Huang co-workers reported first use 2-dimensional OCT 1991, suggesting principle its ophthalmology interventional cardiology.The method has developed rapidly since that time.Interventional cardiologists benefit from detailed intravascular imaging ability, providing real-time information intracoronary...
Mitrální regurgitace (MiR) je druhou nejčastější chlopenní vadou vyžadující chirurgické řešení. Významná MiR jednoznačně spojena s nepříznivou prognózou, avšak téměř polovina pacientů touto není operována z důvodu vysokého perioperačního rizika. Implantace MitraClipu (Abbott Vascular-Structural Heart, Menlo Park, Kalifornie, USA) rozvíjející se perkutánní "edge-to-edge" plastika mitrální chlopně napodobující Alfieriho operaci. Příznivý bezpečnostní profil spolu zlepšením funkční kapacity a...
Objective The introduction of primary percutaneous coronary intervention (PPCI) has modified the profile ST elevation myocardial infarction (STEMI) patients. Occurrence and prognostic significance hypotension episodes are not known in PPCI treated STEMI It is also whether and/or how correlate with degree damage there any sex differences. Methods Data 293 consecutive patients (189 males) by without cardiogenic shock were analyzed. Blood pressure was measured noninvasively. A hypotensive...
To investigate whether and in which patients with catheter-derived low pressure gradient (PG, <40 mmHg) severe (aortic valve area ≤ 1 cm2) aortic stenosis preserved left ventricular ejection fraction, early replacement (AVR) might improve survival.We investigated a total of 506 consecutive (age 75 ± 9 years, 58% men) either moderate (MAS) or (SAS) fraction (≥50%) as defined at catheterization. Propensity score matching was used to select matched pairs without AVR each group. A 100% complete...
Transradial catheterization is the predominant access site for coronary and percutaneous interventions (PCI). Previous studies have reported a high incidence of radial artery (RA) injury. The aim this investigation was to evaluate RA injury using last generation optical coherence tomography (OCT) intravascular imaging in serial manner.100 patients with diagnosis non-ST-elevation myocardial infarction (nSTEMI) treated by PCI were enrolled. OCT performed immediately after index PCI. repeated 9...