A5082115800- Cardiovascular Function and Risk Factors
- Dementia and Cognitive Impairment Research
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Cardiovascular and exercise physiology
- Alzheimer's disease research and treatments
- ECG Monitoring and Analysis
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiac pacing and defibrillation studies
- Blood Pressure and Hypertension Studies
- Neurological Disease Mechanisms and Treatments
- Lipoproteins and Cardiovascular Health
- Aortic Thrombus and Embolism
- Heart Rate Variability and Autonomic Control
- Memory and Neural Mechanisms
- Cardiac electrophysiology and arrhythmias
- Ultrasound in Clinical Applications
- Advanced X-ray and CT Imaging
- Cancer, Lipids, and Metabolism
- Cardiac Arrhythmias and Treatments
- Functional Brain Connectivity Studies
- Cardiovascular Issues in Pregnancy
- Coronary Artery Anomalies
Monash University
2014-2025
Monash Health
2012-2025
Monash Medical Centre
2014-2025
Baker Heart and Diabetes Institute
2018-2024
Doncaster College
2024
The University of Queensland
2024
Alfred Health
2019-2022
Menzies Institute for Medical Research
2018
Acadia University
2009-2014
Hammersmith Hospital
2007-2013
Despite convenience, accessibility, and strong correlation to severity of Alzheimer disease (AD) pathology, medial temporal lobe atrophy (MTA) has not been used as a criterion in the diagnosis prodromal probable AD.
Ambulatory treatment of decompensated heart failure (HF) with intravenous (IV) furosemide through Hospital in the Home (HITH) is safe, effective and reduces costs. We hypothesised that this service was underutilised by general medicine aimed to examine potential barriers bed-day utilisation implications. In multi-site, retrospective observational study, we identified inpatients admitted between November 2021 October 2022. Those who required for >24 h were selected included if clinically...
Epicardial adipose tissue (EAT) is associated with cardiovascular risk. The longitudinal change in EAT volume (EATv) and density (EATd), potential modulators of these parameters, has not been described. We prospectively recruited 90 patients non-obstructive coronary atherosclerosis on baseline computed tomography angiography (CTCA) performed for suspected artery disease to undergo a repeat research CTCA. EATv millilitres (mL) EATd Hounsfield units (HU) were analysed multivariable regression...
Subjects with mild cognitive impairment (MCI) and Alzheimer disease (AD) can be distinguished from elderly subjects no (NCI) by the degree of atrophy in entorhinal cortex (ERC) hippocampus (HPC), quantified volumetric magnetic resonance image (MRI) studies. Because MRI requires rigorous standards for acquisition analysis is not suitable routine clinical use, we have used calibrated visual rating to measure ERC, HPC, perirhinal (PRC) evaluated its utility diagnosis very early AD. Methods:...
<h3>BACKGROUND AND PURPOSE:</h3> White matter hyperintensities (WMHs) are frequently characterized as markers of cerebrovascular disease, whereas medial temporal atrophy (MTA) is a recognized marker Alzheimer disease (AD). Our purpose was to test the reliability visual rating system (VRS) in evaluating WMHs and MTA distinguishing healthy from cognitively impaired subjects. <h3>MATERIALS METHODS:</h3> Subjects (<i>n</i> = 192) enrolled Florida Alzheimer9s Disease Research Center were...
Abstract Background/Aims To investigate the clinical features and rates of progression conditions that are not considered to be normal, but do fulfill criteria for mild cognitive impairment (MCI). Methods We longitudinally evaluated 269 elderly subjects who did meet formal MCI at baseline had: (1) a history suggesting without neuropsychological deficits (PreMCI‐Clinical); or (2) on one more memory measures in conjunction with negative examination (amnestic PreMCI‐NP) were normal both...
In Alzheimer's disease, neurodegenerative atrophy progresses from the entorhinal cortex (ERC) to hippocampus (HP), limbic system and neocortex. The significance of very mild ERC HP on MRI scans among elderly subjects is unknown.A validated visual rating coronal was used identify no or (HP(0); ERC(0)), minimal (HP(ma); ERC(ma)), 414 participants. Subjects fell into following groups: (1) ERC(0)/HP(0), (2) ERC(ma)/HP(0), (3) ERC(0)/HP(ma), (4) ERC(ma)/HP(ma). volume independently measured using...
Abstract Background Recent guidelines propose N-terminal pro-B-type natriuretic peptide (NT-proBNP) for recognition of asymptomatic left ventricular (LV) dysfunction (Stage B Heart Failure, SBHF) in type 2 diabetes mellitus (T2DM). Wavelet Transform based signal-processing transforms electrocardiogram (ECG) waveforms into an energy distribution waveform (ew)ECG, providing frequency and features that machine learning can use as additional inputs to improve the identification SBHF....
The purpose of this study was to determine the core biological processes perturbed in subcutaneous adipose tissue familial combined hyperlipidemia (FCHL) patients. Annotation FCHL and control microarray datasets revealed a distinctive transcriptome, characterized by gene expression changes regulating five overlapping systems: cytoskeleton, cell adhesion extracellular matrix; vesicular trafficking; lipid homeostasis; cycle apoptosis. Expression values for cell-cycle inhibitor CDKN2B were...
Objective To evaluate the need for and feasibility of a pharmacist‐led physician‐supported deprescribing model. Methods All patients aged ≥65 years, with polypharmacy, admitted to acute general medical unit ( GMU ) an Australian tertiary hospital over 6‐week period were prospectively evaluated by team pharmacists. Clinical decision‐making was supported physicians. Results One hundred twenty‐nine met inclusion criteria, 58 (45%) identified deprescribing. Ninety‐two (7.2%) instances 1277...
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