A5053883382- Dementia and Cognitive Impairment Research
- Neurological Disease Mechanisms and Treatments
- Chemical Reactions and Isotopes
- Functional Brain Connectivity Studies
- Cerebrovascular and Carotid Artery Diseases
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Prostate Cancer Treatment and Research
- Biological Research and Disease Studies
- Neurological Disorders and Treatments
- Natural Language Processing Techniques
- Computational Drug Discovery Methods
- Radiomics and Machine Learning in Medical Imaging
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical effects in animals
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Extracellular vesicles in disease
- Enzyme function and inhibition
- Acute Ischemic Stroke Management
- Metal complexes synthesis and properties
- MicroRNA in disease regulation
- Radiopharmaceutical Chemistry and Applications
- Free Radicals and Antioxidants
Mudanjiang Medical University
2016-2025
Education Department of Heilongjiang Province
2023
Guangdong Medical College
2021-2022
Gaozhou People's Hospital
2021-2022
Heilongjiang Provincial Hospital
2020
Capital Medical University
2018-2019
Qinghai Normal University
2010-2016
Chinese Academy of Sciences
2016
Chinese Academy of Social Sciences
2016
Beijing Language and Culture University
2010
Background: The hippocampus and hippocampal subfields have been found to be diversely affected in Alzheimer's Disease (AD) early stages of disease by neuroimaging studies. However, our knowledge is still lacking about the trajectories atrophy with progression disease.. Objective: To identify which differ magnetic resonance imaging (MRI) determine whether individual differences on memory could explained structural volumes subfields. Methods: Four groups participants including 41 AD patients,...
Trace elements play a critical role in the pathogenesis of autism spectrum disorders (ASD). The aim this study was to investigate serum levels zinc (Zn) and copper (Cu) Chinese children with ASD. Sixty patients (48 males, 12 females) diagnosed ASD 60 healthy sex-matched age-matched control participants were assessed for Zn Cu content at admission. severity also evaluated using Childhood Autism Rating Scale (CARS) score. results indicated that mean Zn/Cu ratio significantly lower compared...
Multiscale entropy (MSE) analysis is a novel entropy-based method for quantifying the complexity of dynamic neural signals and physiological systems across multiple temporal scales.This approach may assist in elucidating pathophysiologic mechanisms amnestic mild cognitive impairment (aMCI) Alzheimer's disease (AD).Using resting-state fNIRS imaging, we recorded spontaneous brain activity from 31 healthy controls (HC), 27 patients with aMCI, 24 AD.The quantitative MSE revealed that reduced...
Background Vascular cognitive impairment (VCI) is a major cause of in the elderly and co-factor development progression most neurodegenerative diseases. With continuing neuroimaging, multiple markers can be combined to provide richer biological information, but little known about their diagnostic value VCI. Methods A total 83 subjects participated our study, including 32 patients with vascular no dementia (VCIND), 21 (VD), 30 normal controls (NC). We utilized resting-state quantitative...
<h3>BACKGROUND AND PURPOSE:</h3> White matter hyperintensities (WMHs) are frequently characterized as markers of cerebrovascular disease, whereas medial temporal atrophy (MTA) is a recognized marker Alzheimer disease (AD). Our purpose was to test the reliability visual rating system (VRS) in evaluating WMHs and MTA distinguishing healthy from cognitively impaired subjects. <h3>MATERIALS METHODS:</h3> Subjects (<i>n</i> = 192) enrolled Florida Alzheimer9s Disease Research Center were...
As an enrichment strategy supplemented by the diagnostic framework of subjective cognitive decline (SCD), SCD plus identifies features that may increase likelihood including future-Alzheimer’s disease (AD) patients. This study aimed to identify shared and distinct atrophy patterns between patients specified amnestic mild impairment (aMCI, a prodromal stage AD) investigate extent automated brain magnetic resonance imaging (MRI) volumetry can differentiate with from normal control (NC)...
This study explored the structural imaging changes in patients with subcortical ischemic vascular disease (SIVD)-vascular cognitive impairment no dementia (VCIND) and correlation between gray matter volume field of to provide new targets for early diagnosis treatment.Our included 15 SIVD-normal (SIVD-NCI), 63 SIVD-VCIND, 26 SIVD-vascular (SIVD-VD), 14 normal controls (NC). T1-weighted images all participants were collected, DPABI SPM12 software used process four groups based on voxels....
Background: Since subjective cognitive decline (SCD) was standardized in 2014, there have been few studies reporting the risk factors and neuropsychological assessment characteristics of SCD (plus) memory clinic. Objective: To characterize by comparing it with normal control (NC), amnesic mild impairment (aMCI), Alzheimer Disease (AD) regarding their demographics, lifestyle, family history dementia, multimorbidity assessments. Methods: A total 135 participants were recruited, including 23...
The rapidly increasing prevalence of cognitive impairment and Alzheimer's disease has the potential to create a major worldwide healthcare crisis. Structural MRI studies in patients with mild are currently attracting considerable interest. It is extremely important study early structural metabolic changes, such as those hippocampus, entorhinal cortex, gray matter structures medial temporal lobe, allow detection disease. microstructural integrity white can be studied diffusion tensor imaging....
Whether insulin resistance (IR) predicts worse functional outcome in ischemic stroke is still a matter of debate. The aim the present study to determine association between IR and risk poor 173 Chinese nondiabetic patients with acute stroke. This prospective, population-based cohort study. Insulin sensitivity, expressed by homeostasis model assessment (HOMA) sensitivity (HOMA index = (fasting × fasting glucose)/22.5). was defined HOMA-IR top quartile (Q4). Functional impairment evaluated at...
Background: Cerebrovascular disease is a common clinical illness. Many patients with cerebrovascular can be accompanied by cognitive impairment. The exosomal microRNA (miRNA)-223-3p related to vascular endothelial injury, synaptic function, inflammatory response, and other mechanisms. In this study, we investigated the levels of plasma miRNA-223-3p in cerebral small vessel (CSVD), order determine whether it could used as more accessible potential biomarker for early diagnosis treatment CSVD....
To the Editor: Accumulating evidence has shown that preclinical stage of Alzheimer's disease (AD) (i.e., asymptomatic amyloidosis) lasts for decades before onset cognitive symptoms, providing a large window early intervention. Amyloid pathology, earliest pathological change associated with AD, can be detected in vivo cerebrospinal fluid (CSF) analysis or positron emission tomography (PET), and its presence is necessary diagnosis AD (pre-AD). However, both PET scans CSF analyses are...
Introduction Neurogranin is known to be significantly elevated in patients with Alzheimer’s disease (AD) and may an effective clinical predictor of cognitive decline neurodegeneration. Amnestic mild impairment (aMCI) intermediate state between normal ageing dementia, the latter which can easily revert AD. There remains significant uncertainty regarding conversion aMCI AD, therefore, elucidating such progression paramount field neuroscience. In this protocol study, we therefore aim...
Changes in white matter (WM) microstructure may relate to the pathophysiology of cognitive impairment. Whether WM differs two common pre-dementia subtypes, vascular mild impairment (VaMCI) and amnestic (aMCI), is largely unknown. This study included 28 VaMCI (12 men, age: 46 ~ 77 years) 34 aMCI patients (14 51 79 years). All underwent a battery neuropsychological tests structural diffusion magnetic resonance imaging (MRI) scanning. was quantified using MRI parameters: fractional anisotropy...
In creation of the Chinese-Tibetan parallel corpus, research alignment at sentence level is an essential topic. At present, there no on alignment. This paper proposes automatic approach for which based dictionary. It a solution to specific problems encountered in alignment, are recognition and caused by different granularity between Chinese word segmentation Tibetan process. Experiment shows precision this 84.8%.
Introduction Amnestic mild cognitive impairment (aMCI) and vascular (VaMCI) comprise the 2 main types of (MCI). The first condition generally progresses to Alzheimer's disease, whereas second is likely develop into dementia (VD). brain structure function patients with MCI differ from those normal elderly individuals. However, whether structures or functions between these subtypes has not been studied. This study designed analyse neuroimages in VaMCI aMCI using multimodality MRI (structural...