A5021530795- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Alzheimer's disease research and treatments
- Advanced MRI Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Ionosphere and magnetosphere dynamics
- Physics of Superconductivity and Magnetism
- Advanced biosensing and bioanalysis techniques
- Molecular Sensors and Ion Detection
- Neural dynamics and brain function
- GNSS positioning and interference
- Tryptophan and brain disorders
- Data Stream Mining Techniques
- Network Security and Intrusion Detection
- Metal and Thin Film Mechanics
- Quantum and electron transport phenomena
- Nanoplatforms for cancer theranostics
- Gut microbiota and health
- Sulfur Compounds in Biology
- Iron-based superconductors research
- Geophysics and Gravity Measurements
- Mobile Crowdsensing and Crowdsourcing
- Health, Environment, Cognitive Aging
- Bioinformatics and Genomic Networks
Beijing Normal University
2022-2025
First Affiliated Hospital of Bengbu Medical College
2025
Sir Run Run Shaw Hospital
2022-2024
Chongqing Normal University
2024
Zhejiang University
2022-2024
Chinese Academy of Sciences
2023-2024
Qingdao University of Science and Technology
2024
Shanghai Institute of Microsystem and Information Technology
2023-2024
University of Chinese Academy of Sciences
2023-2024
Shanghai Public Health Clinical Center
2024
Purpose To determine whether individuals with subjective cognitive decline (SCD), which is defined by memory complaints normal performance at objective neuropsychologic examinations, exhibit disruptions of white matter (WM) connectivity and topologic alterations the brain structural connectome. Materials Methods Diffusion-tensor magnetic resonance imaging graph theory approaches were used to investigate organization connectome in 36 participants SCD (21 women: mean age, 62.0 years ± 8.6...
Purpose To determine whether individuals with subjective cognitive decline (SCD) exhibit functional and structural brain alterations by using resting-state magnetic resonance (MR) imaging. Materials Methods This study received institutional review board approval, all participants gave informed consent. Resting-state MR imaging techniques were used to measure amplitude of low-frequency fluctuations (ALFF) regional gray matter volume in 25 subjects SCD (mean age, 65.52 years ± 6.12) 61 control...
Individuals diagnosed with mild cognitive impairment (MCI) are at high risk of transition to Alzheimer's disease (AD). However, little is known about functional characteristics the conversion from MCI AD. Resting-state magnetic resonance imaging was performed in 25 AD patients, 31 and 42 well-matched normal controls baseline. Twenty-one patients converted approximately 24 months follow-up. Functional connectivity strength (FCS) seed-based analyses were used assess differences among groups....
Introduction Understanding the biological mechanism of subjective cognitive decline (SCD) in preclinical Alzheimer’s disease (AD) and identifying those who will soon convert to mild impairment (MCI) are critical for developing appropriate strategies early diagnosis intervention AD. We present study protocol Sino Longitudinal Study on Cognitive Decline (SILCODE), a longitudinal observational focusing SCD context Methods analysis Within SILCODE, approximately 800 subjects with between 50 79...
Substantial studies have reported the prevalence and affecting factors of subjective cognitive decline (SCD). The complaints screening scale has also been used for probing. However, little is known in China.To investigate risk SCD, explore an SCD China.Stratified cluster random sampling was conducted. 2,689 residents aged 60-80 years completed questionnaire 1. 814 were included clinical neuropsychological evaluations. Two standards to make diagnosis mild impairment (MCI) a preliminary rate...
Subjective cognitive decline (SCD) is the earliest symptomatic manifestation of preclinical Alzheimer's disease (AD). Gut microbiota may serve as a susceptibility factor for AD. Altered gut has been reported in patients with mild impairment (MCI) and AD dementia. However, whether microbial compositions changed SCD remains largely unknown.To characterize SCD.In this study, total 105 participants including 38 normal controls (NC), 53 individuals SCD, 14 (CI) were recruited. all isolated from...
Pyroptosis has attracted widespread concerns in cancer therapy, while the therapeutic efficiency could be significantly restricted by using crucial pyroptosis checkpoint of autophagy and tumor hypoxia. Herein, a DNA nanocomplex (DNFs@ZnMn), containing cascade DNAzymes, promoter-like ZnO2-Mn nanozymes photosensitizers, was constructed one pot through rolling circle amplification reactions to induce disrupting autophagy. After targeting cells with high expression H+ glutathione, DNFs@ZnMn...
A platform of glass electrospray coupled with mass spectrometry is developed to rapidly detect living cells cultured on slides.
<title>Abstract</title> <bold>Background and Aims</bold>: Xininurad is an inhibitor of URAT1 that inhibits reabsorption uric acid in the kidneys thus serves as a treatment for hyperuricaemia gout. The purpose this trial was to evaluate pharmacokinetics, pharmacodynamic characteristics safety single fast oral administration tablets subjects with different degrees impaired renal function. <bold>Methods: </bold>A parallel, open, single-dose study design adopted. To end, 22 patients varying...
Subjective cognitive decline (SCD) is characterized by self-reported deficits without measurable impairment. It has been suggested that individuals with SCD exhibited brain structural alterations in widespread cortical thinning or gray matter loss the medial temporal and frontotemporal regions. Apolipoprotein E (APOE) ε4 allele thought to be a genetic marker associated risk of SCD. Neuropsychiatric symptoms may provide insight detecting higher-risk elders for early Alzheimer's disease as...
Background: Early prediction of disease progression in patients with amnestic mild cognitive impairment (aMCI) is important for early diagnosis and intervention Alzheimer's (AD). Previous brain network studies have suggested topological disruptions the connectome aMCI patients. However, whether markers at baseline can predict longitudinal conversion from to AD remains largely unknown. Methods: In this study, 52 26 demographically matched healthy controls a cohort were evaluated. During 2...
We present a new approach to construct dual response fluorescent probe by step-wise functionalization of polysiloxanes.
Background: Education plays a potential important effect on the prevalence and incidence of dementia. However, most evidence based convenience sampling. Objective: To explore effects education cognition in individuals with subjective cognitive decline (SCD) impairment (CI) from population-based study. Methods: We examined among SCD (n = 451) CI 280) A series neuropsychological tests memory, executive, language, general function were used to assess participants. Results: Multiple regression...
DNA nanoframeworks, with great biological information and controlled framework structures, exhibit potentials in applications. Their applications are normally limited by unstable structures susceptible to hydrolysis, depurination, depyrimidination, oxidation, alkylation, or nuclease degradations. Herein, ensure the mechanical chemical stabilities of nanoframeworks for intracellular applications, biomineralization multifunctional a tetrahedral skeleton is employed. Via silicification, S–S...
As an essential gasotransmitter, carbon monoxide (CO) had gradually become a research hotspot in that it possessed important physiological functions and unique pharmacological properties. However, to date, no report has focused on the topic of detecting CO both vivo using films. To open up new field probes, for first time, we designed probe (PMAH-CO) showed distinctive ratio emission characteristic displayed quantitative distribution HeLa cells zebrafish with higher signal-to-noise ratio....
Abstract Quantum phase slip (QPS) is an important effect that occurs in one-dimensional (1D) or quasi-1D superconducting (SC) materials. Due to the extremely high requirements on uniformity and quality of SC nanowires, it currently very challenging obtain repeatable controllable QPS devices. Here, we report a systematic study NbN nanowires. High-quality nanowires with different widths are fabricated by combining processes photo-lithography, electron beam lithography, inductively coupled...
Design and synthesis of a novel fluorene-based polymer probe for selectively detecting SCN<sup>−</sup>.
Hydrogen sulfide (H<sub>2</sub>S) is considered as an important endogenous gaseous signaling molecule in biological systems.