A new ion source based on dielectric barrier discharge was developed as an alternative ionization for ambient mass spectrometry. The source, termed DBDI herein, composed of a copper sheet electrode, and piece glass slide in between well sample plate. Stable low-temperature plasma formed the tip electrode surface when alternating voltage applied electrodes. Analytes deposited were desorbed ionized by ions introduced to spectrometer analysis. capability this demonstrated with analysis 20 amino...

Nanozymes have shown great promise in reactive oxygen species (ROS)-mediated tumor therapy with mitigated side effects but are normally limited by the complex microenvironment (TME). Herein, to overcome adverse of TME, such as hypoxia and high endogenous glutathione (GSH), an aptamer-functionalized Pd@MoO3–x nano-hydrangea (A-Pd@MoO3–x NH) is constructed for high-efficiency cancer therapy. Utilizing irregular shape characteristics nano Pd, A-Pd@MoO3–x NH nanozyme simultaneously exposes...

Abstract Single-atom catalysts (SACs) have attracted interest in photodynamic therapy (PDT), while they are normally limited by the side effects on normal tissues and interference from Tumor Microenvironment (TME). Here we show a TME-activated situ synthesis of SACs for efficient tumor-specific water-based PDT. Upon reduction upregulated GSH TME, C 3 N 4 -Mn obtained TME with Mn atomically coordinated into cavity nanosheets. This overcomes toxicity random distribution catalyst release...

Most of the nanozymes have been obtained based on trial and error, for which application is usually compromised by enzymatic activity regulation due to a vague catalytic mechanism. Herein, hollow axial Mo–Pt single-atom nanozyme (H-MoN5@PtN4/C) constructed two-tier template capture strategy. The ligand can induce Mo 4d orbital splitting, leading rearrangement spin electrons (↑ ↑ → ↑↓) regulate activity. This creates catalase-like enhances oxidase-like catalyze cascade reactions (H2O2 O2...

A high-throughput and controllable synthesis of colloidal CsPbX₃ perovskite NCs with tunable properties morphologies was achieved by microwave irradiation within minutes.

Following an experimental work, we employed density functionals B3LYP, BHANDH, HSE06, PBEPBE, and M06 to inspect the impact of In-doping on a ZnO nanosheet sensitivity acetylene gas. The interaction pristine sheet with was found be weak, sensing response is 1.7 based B3LYP results. Doping In atom into increases adsorption energy from −3.6 −20.4 kcal/mol. Energy decomposing analysis suggests that nature mainly electrostatic, indicating π-cation interaction. significantly rises 38 by...

Abstract Single‐atom nanozymes (SAzymes) have obtained increasing interest to mimic natural enzymes for efficient cancer therapy, while challenged by chemoresistance from cellular redox homeostasis and the interface of reductive species in tumor microenvironment (TME). Herein, a dual single‐atomic ultrathin 2D metal organic framework (MOF) nanosheet multienzyme (Pd/Cu SAzyme@Dzy) is prepared synergistically overcome enhanced catalytic therapy. The Pd SAzyme exhibits peroxidase (POD)‐like...

The electron spin orbital was regulated by sulfur doping of Ti vacancies, which efficiently manipulated flip for enhancing PEC water splitting performance.

SnO2/multi-walled carbon nanotube (MWCNT) nanocomposites were prepared via oxidation of SnCl2 in a supercritical CO2?methanol mixture containing MWCNTs. The as-prepared characterized by means x-ray diffraction, photoelectron spectroscopy, and transmission electron microscopy. It was indicated that SnO2 nanoparticles with size 3?5?nm uniformly tightly decorated on the chemiluminescence characteristic to H2S electrochemical performance SnO2/MWCNT composites investigated. exhibited extremely...

Optical antennas with anisotropic metal nanostructures are widely used in the field of fluorescence enhancement based on localized surface plasmons (LSPs). They overcome intrinsic defects low brightness near-infrared (NIR) dyes and can be to develop sensitive NIR sensors for bioapplications. Here, we demonstrate a novel plasmon-enhanced (PEF) system consisting elongated gold nanobipyramids (Au NBPs) antennas, silica, dyes. Silica was chosen as rigid spacer regulate distance between Maximum...

Compared with traditional visible light-driven fluorescence visualization (FV), near-infrared (NIR)-induced FV is an interesting and promising method, while photoelectrochemical (PEC) immunoassay sensing possesses the advantages of high sensitivity, low cost, simple instrumentation. We combined PEC NIR-induced together developed a dual readout platform. In this protocol, based on antibody–analyte (i.e., antigen, DNA, RNA) reaction sandwich-type structure, CuInS2 microflowers as matrix...

Selective and specific dihydrogenation of benzene other arenes has been observed in a low-temperature helium plasma. A surface Birch reduction mechanism proposed which molecules adsorbed on the discharge capture low-energy surface-adsorbed electrons subsequently undergo protonation (see picture). Gas-phase oxidation processes accompany reaction.

High-throughput screening of catalysts could dramatically improve performance and reduce costs in the discovery study various catalysts. Here we report a cataluminescence-based array imaging as high-throughput technique combinatorial active for CO oxidation. This strategy is based on fact that oxidation generates cataluminescence emission surface nanomaterials, whose intensity correlated to activity catalyst. To demonstrate feasibility catalysts, different nanosized metal supported TiO(2)...

The direct extraction, desorption and ionization of in gel-intact proteins after electrophoresis have been achieved by CNTs-modified paper spray MS at ambient conditions.

Abstract Two compounds, 9,10‐bis[2‐(quinolyl)vinyl]anthracene (BQVA) and 9,10‐bis[2‐(naphthalen‐2‐yl)vinyl]anthracene (BNVA), have been synthesised investigated. Both of them aggregation‐induced enhanced emission (AIEE) properties. Heteroatom‐assisted BQVA shows solvatochromism, reversible chromism properties self‐assembly effects. When increasing the solvent polarities, green solution turns to orange with a redshift fluorescence wavelengths from λ =527 565 nm. Notably, exhibits properties,...

Tyrosinase (TYR) plays a vital role in melanin biosynthesis and is widely regarded as relatively specific marker for melanocytic lesions which involve vitiligo, malignant cutaneous melanoma, Parkinson's disease (PD), etc. However, the detection of TYR living cells with fluorescent probes usually interfered by diverse endogenous reactive oxygen species (ROS) nitrogen (RNS). Herein, we synthesized melanosome-targeting near-infrared (NIR) probe (HB-NP) large Stokes shift (195 nm), achieving...

Carbon nanodots (C-dots) are recently well examined due to the emissions with color-tuning and nonblinking properties, while more studies still needed for appropriate understanding application of distinct emissions. In this work, we found emission chemiluminescence (CL) by introducing low-temperature plasma (LTP) into C-dots solutions without any reagent added, whose intensity was affected presence different metal ions. Based on both experimental data theoretical calculations, ozonation...

An upconversion nanoparticle (UCNP)-based fluorescence resonance energy-transfer (FRET) strategy is normally restricted by the complicated preparations, low efficiency, and challenge on improving specificity. Herein, simple DNA-functionalized UCNPs were designed as energy donors for constructing a FRET-based probe to detect liver-specific microRNA 122 (miR-122). To improve FRET constructed with confined core–shell structures, in which emitting ions precisely located thin shell make them...

The new development of noninvasive diagnosis in breath analysis requires the fabrication inexpensive and rapid sensing technologies, whose mechanisms are further encouraged to be studied. Here based on dramatically enhanced plasma-assisted cataluminescence (PA-CTL) signals, a sensor was constructed for detection acetone, an important biomarker diabetes mellitus breath. As demonstrated, PA-CTL-based showed good sensitivity, repeatability, selectivity acetone detection, which also displayed...

Across machine learning (ML) sub-disciplines, researchers make explicit mathematical assumptions in order to facilitate proof-writing. We note that, specifically the area of fairness-accuracy trade-off optimization scholarship, similar attention is not paid normative that ground this approach. Such presume 1) accuracy and fairness are inherent opposition one another, 2) strict notions equality can adequately model fairness, 3) it possible measure decisions independent from historical...

Synergism of oxygen–iodine binary vacancies to interfacial electric field was developed by a cascade electrospray-annealing preparation, which enhanced CO 2 photoreduction over V O–I -BiOCl/BiOI atomic-thin nanosheets.

Pyroptosis has attracted widespread concerns in cancer therapy, while the therapeutic efficiency could be significantly restricted by using crucial pyroptosis checkpoint of autophagy and tumor hypoxia. Herein, a DNA nanocomplex (DNFs@ZnMn), containing cascade DNAzymes, promoter-like ZnO2-Mn nanozymes photosensitizers, was constructed one pot through rolling circle amplification reactions to induce disrupting autophagy. After targeting cells with high expression H+ glutathione, DNFs@ZnMn...