A5017977346- Diamond and Carbon-based Materials Research
- Metal and Thin Film Mechanics
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal motility and disorders
- Advanced materials and composites
- Tribology and Wear Analysis
- Radiomics and Machine Learning in Medical Imaging
- Lubricants and Their Additives
- COVID-19 and Mental Health
- Food Security and Health in Diverse Populations
- Eosinophilic Disorders and Syndromes
- Lung Cancer Treatments and Mutations
- SARS-CoV-2 and COVID-19 Research
- Pluripotent Stem Cells Research
- Melanoma and MAPK Pathways
- Long-Term Effects of COVID-19
- Neuroscience and Neural Engineering
- Prostate Cancer Treatment and Research
- Vitamin D Research Studies
- COVID-19 and healthcare impacts
- Lung Cancer Research Studies
- Electrospun Nanofibers in Biomedical Applications
- Nutrition and Health in Aging
- IgG4-Related and Inflammatory Diseases
- PARP inhibition in cancer therapy
Guangdong Academy of Medical Sciences
2024-2025
Southern Medical University
2024-2025
Guangdong Provincial People's Hospital
2024-2025
South China University of Technology
2021-2025
Repairment and replacement of organs tissues are part the history struggle against human diseases, in addition to research development (R&D) drugs. Acquisition processing specific substances physiological signals very important understand effects pathology treatment. These depend on available biomedical materials. The family diamond-like carbon coatings (DLCs) has been extensively applied many industrial fields. DLCs have also demonstrated be biocompatible, both vivo vitro. In cases,...
Targeted therapy has dramatically altered the treatment paradigm for some patients with inflammatory myofibroblastic tumor (IMT) that possesses specific molecular aberrations. IMT is an exceedingly rare type of sarcoma, about 50% cases featuring anaplastic lymphoma kinase (ALK) gene rearrangements. The ALK fusions using tyrosine inhibitors (TKIs) become increasingly common. However, until now, there a lack evidence supporting efficacy third-generation ALK-TKIs in this disease category. Here,...
Abstract Programmed death ligand 1 (PD‐L1) is widely known as an immune checkpoint, and immunotherapy through the inhibition of checkpoint molecules has become important component in successful treatment tumours via programmed (PD‐1)/PD‐L1 signalling pathways. However, its biological functions expression profile colorectal cancer (CRC) are elusive. We previously found that PD‐L1 can bind to cause cell detachment. detailed molecular mechanisms how binds it transmits signals remain unclear. In...
Parkinson's disease (PD) is a neurological disorder that often affects middle-aged and elderly people. It primarily characterized by the degeneration of dopaminergic (DA) neurons in ventral midbrain. Clinical therapy mostly relies on holistic approach pharmaceutical intervention surgical procedures. Nevertheless, therapies might just alleviate symptoms temporarily then result notable adverse consequences, ultimately failing to produce therapeutic outcome. Stem cells has benefits being...
Diamond-like carbon (DLC) coatings deposited onto high-speed-steel surfaces were subjected to deep cryogenic treatment (DCT) at temperatures of −120 −196 °C investigate the evolution microstructure, bonding structure, and mechanical properties. The surface morphology structure DLC studied using scanning electron microscopy, transmission micro-Raman spectroscopy, X-ray photoelectron spectroscopy. It is found that DCT affects morphology, especially size height aggregates. For those DLCs with...
Colorectal cancer (CRC) is one of the most common gastrointestinal malignancies. Vasorin (VASN) has been reported to be critical in tumor development and angiogenesis. However, VASN not CRC, its role unclear. In this study, expression upregulated CRC compared with normal tissues, positively correlates N stage poor overall survival by analysis different datasets 32 clinicopathologic samples. Overexpression significantly promotes cell progression, including proliferation, migration, invasion,...
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI
: COVID-19 has been ravaging the globe for more than three years. Due to systemic immunosuppression of anti-tumor therapy, application chemotherapy and adverse effects surgery, short- long-term prognosis cancer patients are significant concern.
Spermatogenesis is a cyclical process in which different generations of spermatids undergo series developmental steps at fixed time and finally produce spermatids. Here, we report that overexpression PD-L1 (B7 homolog1) the testis causes sperm disorders infertility male mice, with severe malformation sloughing during spermatid development, characterized by disorganized collapsed seminiferous epithelium structure. needs to be simultaneously expressed on Sertoli cells spermatogonia cause...
WC-Co cermet was plasma-nitrided with the assistance of a hollow cathode ion source at 400 °C under vacuum 3–8 Pa. Hot film chemical vapor deposition (HFCVD) diamond coating carried out on nitrided specimen, without etching. Scanning electronic microscopy, electron probing X-ray diffraction, and photoelectron spectroscopy were used to characterize surface microstructure nitride specimens coatings. A thin conversion layer specific structure formed, in which primary Co binder transformed into...