A5101480582- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Fault Detection and Control Systems
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Hydrocarbon exploration and reservoir analysis
- Advanced Measurement and Detection Methods
- Semiconductor materials and devices
- Geoscience and Mining Technology
- Machine Learning and ELM
- Advanced Algorithms and Applications
- Energetic Materials and Combustion
- Advancements in Semiconductor Devices and Circuit Design
- Ferroptosis and cancer prognosis
- Immunotherapy and Immune Responses
- Geological Studies and Exploration
- Mineral Processing and Grinding
- Spectroscopy and Chemometric Analyses
- Ferroelectric and Negative Capacitance Devices
- Silicon Carbide Semiconductor Technologies
- Gender Diversity and Inequality
- Fatigue and fracture mechanics
- Advanced Control Systems Optimization
- Integrated Circuits and Semiconductor Failure Analysis
- Immune cells in cancer
Shenyang Institute of Automation
2021-2025
Chinese Academy of Sciences
2021-2025
Guangdong Academy of Medical Sciences
2021-2024
Guangdong Provincial People's Hospital
2021-2024
Southern Medical University
2023-2024
South China University of Technology
2021-2024
University of Chinese Academy of Sciences
2021-2023
China National Petroleum Corporation (China)
2022
Research Institute of Petroleum Exploration and Development
2018-2021
Peking University
2020
Background The liver is a frequent site of metastases and (LM) correlate with diminished immunotherapy efficacy in non-small cell lung cancer (NSCLC). This study aimed to analyze whether tumor response differs between pulmonary lesions (PL) LM NSCLC explore potential mechanisms through multiomics analysis. Methods observational longitudinal clinical cohort included patients receiving was conducted evaluate organ-specific PL LM. We collected paired samples the difference using whole-exome...
No direct comparison has been performed between different programmed cell death-1 (PD-1) inhibitors for first-line treatment in patients with advanced non-small lung cancer (NSCLC). The feasibility of using PD-L1-expression-guided immunotherapy remains unknown. In this open-label, phase 2 study (NCT04252365), NSCLC without EGFR or ALK alterations were randomized (1:1) to receive sintilimab pembrolizumab monotherapy (PD-L1 expression ≥50%), plus platinum-based chemotherapy <50%). sample size...
Abstract Background The effects of gut microbiota and metabolites on the responses to immune checkpoint inhibitors (ICIs) in advanced epidermal growth factor receptor (EGFR) wild-type non-small cell lung cancer (NSCLC) have been studied. However, their EGFR -mutated (EGFR + ) NSCLC remain unknown. Methods We prospectively recorded clinicopathological characteristics patients with assessed potential associations between use antibiotics or probiotics immunotherapy efficacy. Fecal samples were...
Aiming at the strong spatio-temporal coupling relationship between data in actual industrial production process, which leads to problem of insufficient reliability and poor timeliness traditional process anomaly monitoring methods, a time series model based on graph similarity network with multi-scale features is proposed, can react anomalies timely effective manner guarantee safety.First, graph-building method for spatio-temporally coupled time-series using multidimensional time-varying...
Aiming at the strong spatio-temporal coupling relationship between data in actual industrial production process, which leads to problem of insufficient reliability and poor timeliness traditional process anomaly monitoring methods, a time series model based on graph similarity network with multi-scale features is proposed, can react anomalies timely effective manner guarantee safety. First, graph-building method for spatio-temporally coupled time-series using multidimensional time-varying...
Response to immune checkpoint inhibitors (ICIs) is affected by multiple factors. This study aimed explore whether sites of metastasis are associated with clinical outcomes ICIs in advanced non-small-cell lung cancer (NSCLC) patients.The data NSCLC patients high programmed death-ligand 1 expression and good performance status receiving first-line monotherapy from Guangdong Provincial People's Hospital between May 2019 July 2020 were retrospectively analyzed. Metastatic included liver, bone,...
9032 Background: Immunotherapy has become standard therapy for untreated advanced NSCLC. However, no direct comparison between anti-PD-1 inhibitors been reported. Methods: CTONG1901 is an open label, randomized, phase II clinical trial to compare sintilimab and pembrolizumab in monotherapy or combination with chemotherapy NSCLC at first-line setting. The primary endpoint was objective response rate (ORR). Patient without EGFR ALK alteration were enrolled. Patients PD-L1 tumor proportion...
Central nervous system (CNS) metastases is inevitable for epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC). AZD3759 a novel EGFR-TKI with impressive CNS penetration.We initiated phase 2, multi-center, umbrella trial (CTONG1702, NCT03574402). The eighth arm assessed the efficacy and safety of in untreated EGFR-mutated NSCLC metastases. primary objective was response rate (ORR). Simon's minimax two-stage design used to calculate sample size. Dose optimal...
Using high-/spl kappa/ Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> doped Ta xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> dielectric, we have obtained record high MIM capacitance density of 17 fF/μm <sup xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> at 100 kHz, small 5% reduction to RF frequency range, and low leakage current 8.9×10/sup -7/ A/cm . In combination both...
We demonstrate for the first time high quality and dislocation free Ge-on-insulator (GOI) p-MOSFETs with Al/sub 2/O/sub 3/ gate dielectrics [EOT=1.7 nm]. Compared to control 3//Si p-MOSFETs, 3//GOI devices show similar leakage current same EOT, 2X increase in drive current, 2.5X hole mobility. In addition, exhibit 1.3X enhanced mobility over SiO/sub 2//Si universal at E/sub eff/ of 1 MV/cm.
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Metabolism reprogramming within the tumor microenvironment (TME) can have a profound impact on immune cells. Identifying association between metabolic phenotypes and cells in lung adenocarcinoma (LUAD) may reveal mechanisms of resistance to checkpoint inhibitors (ICIs). Metabolic were classified by expression genes. Somatic mutations transcriptomic features compared across different phenotypes. The phenotype LUAD is predominantly determined reductase-oxidative activity divided into two...
In the past, chemoradiotherapy (CRT) has been standard of care for inoperable stage III NSCLC. Concurrent (cCRT), if tolerable in patients, is optimal treatment regimen. A meta-analysis shown that cCRT results a 5-year survival rate 4.5% longer than with
We have fabricated on Pt and 4 nm substrates. Although has a larger dielectric constant grain size than those the thin films both substrates show good capacitance-voltage characteristics same threshold voltage shift of ∼3.6 V. Moreover, leakage current density at −10 V is nearly three orders magnitude lower that Pt. The comparable memory are important for continuous scaling down ferroelectric memory. © 2001 Electrochemical Society. All rights reserved.
Abstract To deal with the highly nonlinear and time-varying characteristics of batch process, a model named Moving Window Stacking Approximate Kernel-Based Broad Learning System (MW-Stacking-AKBLS) is proposed in this paper. This innovatively introduces AKBLS algorithm MW-Stacking framework, giving it strong fitting ability, excellent generalization adaptive ability. The (BLS) known for its shorter training time effective processing, but uncertainty brought by double random mapping results...
Abstract To deal with the highly nonlinear and time-varying characteristics of Batch Process, a model named adaptive stacking approximate kernel based broad learning system is proposed in this paper. This innovatively introduces (AKBLS) algorithm Adaptive Stacking framework, giving it strong fitting ability, excellent generalization ability. The Broad Learning System (BLS) known for its shorter training time effective processing, but uncertainty brought by double random mapping results poor...
In the contemporary era of globalization and social diversity, diversity inclusive culture have become key aspects human resource management. This promotes integration different backgrounds perspectives, which can effectively enhance employees’ creativity, company’s innovation capabilities, market competitiveness. article explores importance in management analyzes how to promote practice this practical work. Firstly, definitions inclusivity their potential benefits enterprise been...
Single-step tightening is simple and fast compared to multi-step tightening, it therefore frequently used during the of bolts in flange structures. However, single-step maintain uniformity more difficult achieve. To address this problem, existing methods such as Elastic Interaction Coefficient Method (EICM) Tetraparametric Assembly (TAM) have been investigated for load tightening. In order improve computational efficiency accuracy traditional methods, a new method proposed paper. This can...
Aiming at the lack of reliable gradual fault detection and abnormal condition alarm evaluation ability in plasticizing process single-base gun propellant, a diagnosis method based on normalized mutual information weighted multiway principal component analysis (NMI-WMPCA) under limited batch samples modelling was proposed. In this method, differences coupling correlation among multi-dimensional variables characteristics linear nonlinear relationships are considered. NMI-WMPCA utilizes...
The 7th Member of the Yanchang Formation (Chang 7 Member) in Ordos Basin contains rich shale oil resources which exploration and development Chang sandstone interbedded has made substantial breakthroughs. potential oil, an inevitableoil gas replacement for Changqing Oilfield Company future, is immense. Its related geological basic research, however, relatively weak. This paper provides elaborations analyzation on science issue, including characteristics mud shale, significance exploration,...