A5100441166- Advanced Harmonic Analysis Research
- Cancer-related molecular mechanisms research
- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- Differential Equations and Boundary Problems
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Mathematical Biology Tumor Growth
- Mathematical Analysis and Transform Methods
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Nonlinear Partial Differential Equations
- Pregnancy and preeclampsia studies
- Nanoparticle-Based Drug Delivery
- Gene Regulatory Network Analysis
- Advanced Mathematical Physics Problems
- Protein Degradation and Inhibitors
- Chronic Myeloid Leukemia Treatments
- Cancer Genomics and Diagnostics
- Advanced biosensing and bioanalysis techniques
- Soft tissue tumor case studies
- Kruppel-like factors research
Southwest Jiaotong University
2025
University of Electronic Science and Technology of China
2020-2024
Hainan Medical University
2024
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2015-2024
First Affiliated Hospital of Xinjiang Medical University
2023
Xinjiang Medical University
2023
Shenzhen Second People's Hospital
2021-2022
Shenzhen Luohu People's Hospital
2021
Shenzhen University
2021
Delft University of Technology
2017-2020
Long noncoding RNAs (lncRNAs) play important roles in the development and progression of human cancers. The lncRNA prostate cancer-associated transcript 1 (PCAT1) has been reported to be involved multiple cancers, including oesophageal squamous cell carcinoma (ESCC). However, detailed biological functions, underlying mechanisms clinical relevance PCAT1 ESCC remain unclear. Here, we confirmed that was highly expressed tissues lines. Knockdown inhibited growth cells, whereas overexpression...
Pre-eclampsia (PE) is a leading cause of maternal and perinatal morbidity mortality but the exact underlying mechanisms PE pathogenesis remain elusive. Accumulated data suggested that long noncoding RNAs (lncRNAs) play important roles in PE. The present study identified changes lncRNA Linc00261 its effects on trophoblasts invasion migration. Our results showed expression was upregulated placental tissues women compared with those healthy pregnant women. Overexpression suppressed cell...
Gastric cancer (GC) is a malignant disease of the digestive tract and life-threatening worldwide. Ferroptosis, an iron-dependent cell death caused by lipid peroxidation, reported to be highly correlated with gastric tumorigenesis immune activity. However, underlying relationship between ferroptosis tumor microenvironment in GC potential intervention strategies have not been unveiled. In this study, we profiled transcriptome prognosis data ferroptosis-related genes (FRGs) samples TCGA-STAD...
Preeclampsia (PE) is a pregnancy-related syndrome characterized by hypertension and proteinuria after the 20th week of gestation. The long noncoding RNAs (lncRNAs) have been recently discovered for their roles in pathogenesis PE. This study aimed at determining expression lncRNA MIR503 host gene (MIR503HG) PE placental tissues exploring molecular mechanism underlying MIR503HG-mediated trophoblast cell proliferation, invasion, migration. level MIR503HG tissues, HTR-8/SVneo, JEG3 cells was...
Abnormal activation of protein kinases and phosphatases is implicated in various tumorigenesis, including hepatocellular carcinoma (HCC). Advanced HCC patients are treated with systemic therapy, tyrosine kinase inhibitors, which extend overall survival. Investigation the underlying mechanism signaling will help to improve efficacy therapy. Combining single-cell RNA sequencing data TCGA RNA-seq data, we profiled kinases, phosphatases, other phosphorylation-related genes (PRGs) this study. We...
Abstract Although RNA interference may become a novel therapeutic approach for cancer treatment, target-site accumulation of siRNA to achieve dosage will be major problem. Microneedle represents better way deliver siRNAs and we have evaluated the first time capability silicon microneedle array delivery Gapdh skin in vivo results showed that arrays could effectively relevant regions noninvasively. For further study this field, efficacy injectable device local mouse xenograft. The presented...
Cell migration, known as an orchestrated movement of cells, is crucially important for wound healing, tumor growth, immune response well other biomedical processes. This paper presents a cell-based model to describe cell migration in non-isotropic fibrin networks around pancreatic islets. determined by the mechanical strain energy density cytokines-driven chemotaxis. displacement modeled solving large system ordinary stochastic differential equations where parts result from random walk. The...
Abstract Multiple myeloma (MM) is an incurable hematological malignancy characterized by abnormal infiltration of plasma cells in the bone marrow. MicroRNAs (miRNAs) have emerged as crucial regulators human tumorigenesis and tumor progression. miR-27, a novel cancer-related miRNA, has been confirmed to be implicated multiple types tumors; however, its biological role MM remains largely unknown. The present study aimed characterize miR-27 elucidate potential molecular mechanisms. Here we...
The present study aimed to examine whether monoclonal immunoglobulin heavy chain (IGH) or T‑cell receptor (TCR) gene rearrangement in cell‑free DNA (cfDNA) may be used for minimal residual disease (MRD) monitoring patients with acute myeloid leukemia (AML). Monoclonal IGH and TCR cfDNA were monitored AML. A total of 94 (40%) had rearrangements at diagnosis; 84% these (79 cases) achieved complete remission following 1‑3 courses induction chemotherapy. Among cases, 89.9% negative consolidation...
Abstract Multiple myeloma (MM) is a malignant neoplasm featured by obvious drug resistance and poor prognosis. MicroRNAs (miRNAs) are class of small noncoding RNAs with crucial roles in many biological processes including cancer initiation progression. The current study aims to investigate the pathogenic role molecular mechanism miRNAs MM resistance. In present study, expression profile samples was analyzed microarray real‐time polymerase chain reaction. Protein expressions were detected...
Cantharidin (CTD) is an active compound isolated from the traditional Chinese medicine blister beetle and displayed anticancer properties against various types of cancer cells.However, little known about its effect on human chronic myeloid leukemia (CML) cells, including imatinib-resistant CML cells.The objective this study was to investigate whether CTD could overcome imatinib resistance in cells explore possible underlying mechanisms associated with effect.Our results showed that strongly...
The IL-6R/JAK2/STAT3 pathway mediated by interleukin-6 (IL-6) plays an important role in the occurrence and development of multiple myeloma (MM), which is associated with decreased microRNA-451a. However, biological function microRNA-451a MM remains unclear. bone marrow (BM) patients was sampled, plasma cells were enriched. BM miR-451a, IL-6 IL-6R levels Ki-67 expression intensity evaluated using reverse transcription-quantitative PCR, ELISA flow cytometry, respectively. U266 cell...
Pancreatic ductal adenocarcinoma (PDAC) is a fatal malignant disease with 5-year survival rate of less than 6%. Activating mutations Kras (mu-Kras) are often detected in most PDAC patients. Although it has been known that oncogenic the driver pancreatic cancer initiation and development, underlying mechanisms by which mu-Kras promotes remain poorly understood. Here, we identify PKCι one crucial factors for supporting cells expressing mu-Kras. Our study demonstrates after knockdown PKCι,...
In the present study, gene expression profiles of acute myeloid leukemia (AML) samples were analyzed to identify feature genes with capacity predict mutation status FLT3/ITD. Two machine learning models, namely support vector (SVM) and random forest (RF) methods, used for classification. Four datasets downloaded from European Bioinformatics Institute, two which (containing 371 samples, including 281 FLT3/ITD mutation-negative 90 mutation‑positive samples) randomly defined as training group,...
In this paper, we establish the boundedness on $ L^r(\mathbb{R}^{n_1}\times\mathbb{R}^{n_2}) of bilinear and bi-parameter pseudo-differential operators whose symbols \sigma(x,\xi,\eta)\in S^{(0,0)}_{(1,1),(\delta_1,\delta_2)} for x,\xi,\eta\in\mathbb{R}^{n_1}\times\mathbb{R}^{n_2} 0\leq\delta_1,\delta_2<1 $, which extends result Dai Lu in [8].