A5051042181- Xenotransplantation and immune response
- Pancreatic function and diabetes
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Mesenchymal stem cell research
- Hematopoietic Stem Cell Transplantation
- Animal Genetics and Reproduction
- Thyroid Cancer Diagnosis and Treatment
- CRISPR and Genetic Engineering
- Virus-based gene therapy research
- Retinal Imaging and Analysis
- Immunotherapy and Immune Responses
- Transplantation: Methods and Outcomes
- Ultrasound and Hyperthermia Applications
- MicroRNA in disease regulation
- Cannabis and Cannabinoid Research
- Retinal Diseases and Treatments
- Ultrasound Imaging and Elastography
- Tissue Engineering and Regenerative Medicine
- Retinal and Optic Conditions
- Corneal surgery and disorders
- Pregnancy and Medication Impact
- Tryptophan and brain disorders
- Cancer-related molecular mechanisms research
- Corneal Surgery and Treatments
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Peking Union Medical College Hospital
2023-2024
University of Florida
2024
Hainan General Hospital
2024
Shanghai University
2023
Sun Yat-sen University
2014-2023
Shenzhen Second People's Hospital
2017-2023
The First Affiliated Hospital, Sun Yat-sen University
2014-2023
Shanghai University of Traditional Chinese Medicine
2022-2023
Xiangya Hospital Central South University
2022-2023
Human mesenchymal stem cells (hMSCs) are currently investigated for a variety of therapeutic applications. However, MSCs isolated from primary tissue cannot meet clinical grade needs and should be expanded in vitro several passages. Although hMSCs show low possibility undergoing oncogenic transformation, they do, similar to other somatic cells, undergo cellular senescence their potential is diminished when cultured vitro. the role senescent tumor progression remains largely elusive. In...
Recurrent pregnancy loss (RPL) is a common fertility problem that affects 1%-2% of couples all over the world. Despite exciting discoveries regarding important roles decidual natural killer cell (dNK) and regulatory T in pregnancy, immune heterogeneity patients with unexplained recurrent (URPL) remains elusive. Here, we profiled transcriptomes 13,953 CD45 + cells from three normal URPL deciduas. Based on our data, cellular composition revealed major populations including dNK cell,...
A green tea–triggered genetic control system was developed for genome/epigenome editing, digital computations, and diabetes therapy in mice monkeys.
Gastric cancer (GC) is a malignant disease of the digestive tract and life-threatening worldwide. Ferroptosis, an iron-dependent cell death caused by lipid peroxidation, reported to be highly correlated with gastric tumorigenesis immune activity. However, underlying relationship between ferroptosis tumor microenvironment in GC potential intervention strategies have not been unveiled. In this study, we profiled transcriptome prognosis data ferroptosis-related genes (FRGs) samples TCGA-STAD...
Abnormal activation of protein kinases and phosphatases is implicated in various tumorigenesis, including hepatocellular carcinoma (HCC). Advanced HCC patients are treated with systemic therapy, tyrosine kinase inhibitors, which extend overall survival. Investigation the underlying mechanism signaling will help to improve efficacy therapy. Combining single-cell RNA sequencing data TCGA RNA-seq data, we profiled kinases, phosphatases, other phosphorylation-related genes (PRGs) this study. We...
Racial and ethnic minorities bear a disproportionate burden of type 2 diabetes (T2D) its complications, with social determinants health (SDoH) recognized as key drivers these disparities. Implementing efficient effective needs management strategies is crucial. We propose machine learning analytic pipeline to calculate the individualized polysocial risk score (iPsRS), which can identify T2D patients at high for hospitalization, incorporating explainable AI techniques algorithmic fairness...
Abstract This study aimed to investigate the association between fruit consumption during second trimester and occurrence of gestational diabetes mellitus (GDM). A prospective with 772 female participants was conducted in China from April 2013 August 2014. Dietary intake assessed face-to-face telephone interviews using a 3-day food record. GDM ascertained standard 75 g 2 hour oral glucose tolerance test. Multivariable logistic regression used estimate odds ratios (ORs) 95% confidence...
On the luminal surface of injured arteries, platelet activation and leukocyte-platelet interactions are critical for initiation progression arterial restenosis. The transcription factor nuclear factor-κB is a molecule in activation. Here, we investigated role pathway forming neointima after injury.We performed carotid artery wire injuries low-density lipoprotein receptor-deficient (LDLR(-/-)) mice with platelet-specific deletion IκB kinase-β (IKKβ) (IKKβ(fl/fl)/PF4(cre)/LDLR(-/-)) control...
To evaluate the diagnostic performance of shear wave elastography (SWE) in differentiation malignant and benign thyroid nodules with coexistent Hashimoto's thyroiditis (HT).Case series chart review.Tertiary general hospital.From September 2012 to January 2014, conventional ultrasound SWE were performed on 243 patients 286 histologic results. The HT group consisted 93 117 nodules. non-HT 140 169 nodules.In nodules, there no significant differences mean, minimum, or maximum values between...
When hyperacute rejection is avoided by deletion of Gal expression in the pig, delayed xenograft (DXR) becomes a major immunologic barrier to successful xenotransplantation. This study was investigate potential antigens involved DXR. We isolated primary renal microvascular endothelial cells (RMEC) and aortic (AEC) from GGTA1/CMAH double-knockout (DKO) pig (and GGTA1-KO pig) immunized cynomolgus monkeys with both these cells. After sensitization, monkey serum antibody binding cytotoxicity...