A5100319391- Metal-Organic Frameworks: Synthesis and Applications
- Magnetism in coordination complexes
- Metal complexes synthesis and properties
- Polyamine Metabolism and Applications
- RNA Interference and Gene Delivery
- Infant Nutrition and Health
- Polyoxometalates: Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Andrographolide Research and Applications
- Mosquito-borne diseases and control
- Antibiotic Resistance in Bacteria
- Chemical Synthesis and Analysis
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- RNA regulation and disease
- Digital Communication and Language
- Sulfur-Based Synthesis Techniques
- Carbohydrate Chemistry and Synthesis
- Inflammasome and immune disorders
- Iron Metabolism and Disorders
- Nanoplatforms for cancer theranostics
- Discourse Analysis in Language Studies
- Fatty Acid Research and Health
- Mindfulness and Compassion Interventions
- Food Allergy and Anaphylaxis Research
Hong Kong Polytechnic University
2024
University of North Carolina at Chapel Hill
2021-2024
Sun Yat-sen University
2006-2024
Peking University
2024
National Sun Yat-sen University
2022
Zhejiang Pharmaceutical College
2021
Guangzhou Medical University
2016-2021
First Affiliated Hospital of Guangzhou Medical University
2016-2021
Sichuan University
2019
Sun Yat-sen Memorial Hospital
2019
Highly ordered three-dimensional α-Fe2O3@PANI core-shell nanowire arrays with enhanced specific areal capacity and rate performance are fabricated by a simple cost-effective electrodeposition method. The provide large reaction surface area, fast ion electron transfer, good structure stability, which all beneficial for improving the electrochemical performance. Here, high-performance asymmetric supercapacitors (ASCs) designed using as anode PANI nanorods grown on carbon cloth cathode, they...
Drug resistance, developed through multiple mechanisms, is a major hindrance to successful chemotherapy of tumor. Combination therapy chemotherapeutic drugs and siRNA represents an emerging strategy which may improve anticancer effect by synergistic actions. In this study, triblock copolymer poly(ethylene glycol)- block-poly(l-lysine)- block-poly aspartyl ( N-( N', N'-diisopropylaminoethyl)) (PEG-PLL-PAsp(DIP)) was synthesized for the first time enable codelivery BCL-2 DOX. The system...
A novel liposomal system incorporating branched PEI was prepared to efficiently codeliver sorafenib and GPC3 siRNA for hepatocellular carcinoma therapy.
A new series of oxovanadium(IV)-lanthanide(III) heteronuclear complexes [Yb(H2O)8]2[(VO)2(TTHA)](3)21 H2O (1), {[Ho(H2O)7(VO)2(TTHA)][(VO)2(TTHA)](0.5)} 8.5 (2), {[Gd(H2O)7(VO)2(TTHA)][(VO)2(TTHA)](0.5)}8.5 (3), {[Eu(H2O)7][(VO)2(TTHA)](1.5)} 10.5 (4), and [Pr2(H2O)6(SO4)2][(VO)2(TTHA)] (5) (H6TTHA=triethylenetetraaminehexaacetic acid) were prepared by using the bulky flexible organic acid H(6)TTHA as structure-directing agent. X-ray crystallographic studies reveal that they contain same...
An impermeable outer membrane and multidrug efflux pumps work in concert to provide Gram-negative bacteria with intrinsic resistance against many antibiotics. These mechanisms reduce the intracellular concentrations of antibiotics render them ineffective. The natural product thiomarinol A combines holothin, a dithiolopyrrolone antibiotic, marinolic acid A, close analogue mupirocin. hybridity converts mupirocin scaffold from inhibiting Gram-positive both -negative bacteria. We found that...
Combination therapy is an effective strategy to combat antibiotic resistance. Multiple synergistic antimicrobial combinations are produced by enzymes encoded in biosynthetic gene clusters (BGCs) that co-localize on the bacterial genome. This phenomenon led hypothesis mining co-localized BGCs will reveal new of natural products. Here, we bioinformatically identified 38 pairs BGCs, which predict produce products related known compounds, including polycyclic tetramate macrolactams (PoTeMs). We...
pH and reduction dual-sensitive polymeric nanovesicles were developed to simultaneously deliver hydrophobic gefitinib hydrophilic doxorubicin for cancer therapy.
Abstract Dinuclear and one‐dimensional copper complexes [Cu 2 (tpa) ( m ‐bda)](ClO 4 ) 1 ), [{Cu (tpm) ‐bda) } · CH 3 OH H O] n (bpm) (H O)} CN [tpa: tris(2‐pyridylmethyl)amine; tpm: tris(pyrazolyl)methane; bpm: bis(pyrazolyl)methane; ‐bda: isophthalate dianion] have been prepared from various polydentate terminal ligands. Complex crystallizes in the monoclinic P / c space group with a = 14.003(6), b 17.201(7), 20.654(9) Å, Z 4, R 0.0678, wR 0.1751. triclinic $\tilde {1}$ 10.250(7),...
Dengue virus (DENV) utilizes host factors throughout its life cycle. In this study, we identified RNA helicase A (RHA), a member of the DEAD/H family, as an important factor DENV. response to DENV2 infection, nuclear RHA protein was partially redistributed into cytoplasm. The short interfering RNA-mediated knockdown significantly reduced amounts infectious viral particles in various cells. multistep growth and Japanese encephalitis but not Zika virus. Further study showed that absence...
Human milk represents the gold standard for infant nutrition, with approximately 50% of energy in human derived from lipids. Odd-chain fatty acids (OCFAs) have been recognized as a category bioactive recent research; however, limited data exist on OCFAs milk. This study collected samples spanning postpartum period 0 to 400 days. Phospholipids containing (PL-OCFAs) were determined 486 using hydrophilic liquid chromatography-electrospray ionization-triquadrupole-mass spectrometry....
Abstract The first ferromagnetic coupled, thiocyanato‐bridged copper( II )‐manganese( ) bimetallic 2D polymer {[Cu(ipa) 2 ] Mn(NCS) 6 ·2H O} n (ipa = 1,2‐propanediamine) has been synthesised and characterised by a single‐crystal X‐ray structure determination variable temperature magnetic susceptibility studies. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Amide N-methylation is important for the activity and permeability of bioactive compounds but can be challenging to perform selectively. The broad-spectrum antimicrobial natural products thiolutin holomycin differ only by an N-methyl group at endocyclic amide thiolutin, exhibits antifungal activity. enzyme responsible N--methylation in biosynthesis has remained elusive. Here, we identified characterized N-methyltransferase DtpM that encoded >400 kb outside gene cluster. catalyzes efficient...