A5014311249- Genomics, phytochemicals, and oxidative stress
- Liver Disease Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Peroxisome Proliferator-Activated Receptors
- Cancer-related Molecular Pathways
- Microtubule and mitosis dynamics
- Innovative Microfluidic and Catalytic Techniques Innovation
- 3D Printing in Biomedical Research
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism, Diabetes, and Cancer
- Cancer Cells and Metastasis
- Endoplasmic Reticulum Stress and Disease
- Glutathione Transferases and Polymorphisms
- Pancreatic function and diabetes
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Drug-Induced Hepatotoxicity and Protection
- PI3K/AKT/mTOR signaling in cancer
- Distributed and Parallel Computing Systems
- Fibroblast Growth Factor Research
- Curcumin's Biomedical Applications
- Advanced Authentication Protocols Security
- Kruppel-like factors research
- Metabolomics and Mass Spectrometry Studies
- Biological Activity of Diterpenoids and Biflavonoids
Yonsei University
2015-2024
Severance Hospital
2015-2023
Korea Institute of Brain Science
2019
Biomedical Research Institute
2017-2018
Sookmyung Women's University
2011-2016
University of Ulsan
2014
Asan Medical Center
2014
Ulsan College
2014
Soonchunhyang University
2013
Sun Moon University
2013
Lipotoxicity, induced by saturated fatty acid (SFA)-mediated cell death, plays an important role in the pathogenesis of nonalcoholic liver disease (NAFLD). The KEAP1 (kelch like ECH associated protein 1)-NFE2L2/NRF2 (nuclear factor, erythroid 2 2) pathway is a pivotal defense mechanism against lipotoxicity. We previously reported that SQSTM1/p62 has cytoprotective lipotoxicity through activation noncanonical KEAP1- NFE2L2 hepatocytes. However, underlying mechanisms and physiological...
Abstract Background and Aims Currently there is no Food Drug Administration–approved drug to treat NAFLD NASH, the rates of which are increasing worldwide. Although NAFLD/NASH highly complex heterogeneous conditions, most pharmacotherapy pipelines focus on a single mechanistic target. Considering importance gut‐liver axis in their pathogenesis, we investigated therapeutic effect long‐acting dual agonist glucagon‐like peptide (GLP)‐1 GLP‐2 receptors mice with NAFLD/NASH. Approach Results...
Hepatic lipotoxicity is a crucial factor in nonalcoholic steatohepatitis resulting from excessive saturated fatty acid-induced reactive oxygen species (ROS)-mediated cell death, which associated with the accumulation of endoplasmic reticulum (ER) stress liver. The unfolded protein response (UPR) alleviates ER by restoring folding homeostasis. However, whether UPR contributes ROS elimination under remains unclear. Kelch like ECH-associated 1 (KEAP1)-nuclear factor, erythroid 2 (Nrf2) pathway...
Background We previously identified ezetimibe, an inhibitor of Niemann–Pick C1-like intracellular cholesterol transporter 1 and European Medicines Agency-approved lipid-lowering agent, as a potent autophagy activator. However, its efficacy against pulmonary fibrosis has not yet been evaluated. This study aimed to determine whether ezetimibe therapeutic potential idiopathic fibrosis. Methods Primary lung fibroblasts isolated from both humans mice were employed for mechanistic in vitro...
The cancerous inhibitor of protein phosphatase 2A (CIP2A) increases the migration and metastasis various cancer cells. Overexpression CIP2A has been shown to increase proliferation MDA-MB-231 We thus assessed whether expression is associated with sensitivity doxorubicin. cells showed an in after treatment doxorubicin, while MCF-7 a decrease expression. overexpression overcame inhibition cell response doxorubicin treatment. was not affected by wild-type or mutant p53. However, p53 blocked...
Saturated fatty acid (SFA)-induced lipotoxicity is caused by the accumulation of reactive oxygen species (ROS), which associated with damaged mitochondria. Moreover, crucial for progression nonalcoholic steatohepatitis (NASH). Autophagy required clearance protein aggregates or mitochondria to maintain cellular metabolic homeostasis. The NFE2L2/NRF2 (nuclear factor, erythroid 2 like 2)-KEAP1 (kelch ECH 1) pathway essential elimination ROS. ULK1 (unc-51 autophagy activating kinase 1; yeast...
Nuclear factor erythroid 2-related 2 (Nrf2) provides a cellular defense against oxidative stress by inducing the expression of antioxidant and detoxification enzymes. The calcium antagonist, verapamil, is an FDA-approved drug prescribed for treatment hypertension. Here, we show that verapamil acts as potent Nrf2 activator without causing cytotoxicity, through degradation Kelch-like ECH-associated protein 1 (Keap1), repressor. Furthermore, verapamil-induced Keap1 prominently mediated...
Abstract Mutation of PPP2R1A has been observed at high frequency in endometrial serous carcinomas but low ovarian clear cell carcinoma. However, the biological role mutation and cancer progression remains unclear. In this study, we found that expression is elevated high-grade primary tumor patients with papillary tumors ovary. To determine whether increased levels or might contribute to progression, effects overexpression on proliferation, migration, PP2A phosphatase activity were...
Abstract Artificial liver models have been extensively developed for pathological modeling and toxicological studies. However, the prediction of existing in vitro rarely corresponds to what is consequently observed vivo owing structural functional complexity liver. Here, a new model designed enable implantation maintenance buds perfusable 3D hydrogels where microvascular network develops within 200 µm diffusion limit developed. This system replicates inflammation, lipid accumulation,...
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is overexpressed in most human cancers and has been described as being involved the progression several malignancies via inhibition (PP2A) activity toward c-Myc. However, with exception this role, cellular function CIP2A remains poorly understood. On basis yeast two-hybrid coimmunoprecipitation assays, we demonstrate here that NIMA (never mitosis gene A)-related kinase 2 (NEK2) a binding partner for CIP2A. exhibited dynamic changes...
Endoplasmic reticulum (ER) stress is triggered by various cellular stresses that disturb protein folding or calcium homeostasis in the ER. To cope with these stresses, ER activates unfolded response (UPR) pathway, but unresolved induces reactive oxygen species (ROS) accumulation leading to apoptotic cell death. However, mechanisms underlie protection from stress-induced death are not clearly defined. The nuclear factor erythroid 2-related 2 (Nrf2)-Kelch-like ECH-associated 1 (Keap1) pathway...
Circulating CTRP1 (C1q/TNF-α [tumor necrosis factor-α]-related protein 1) levels are increased in hypertensive patients compared with those healthy subjects. Nonetheless, little is known about the molecular and physiological function of blood pressure (BP) regulation.To investigate physiological/pathophysiological role BP regulation.CTRP1 production was to maintain normotension under dehydration conditions, this impaired inducible KO (knockout) mice (CTRP1 ΔCAG). The increase conditions...
Abstract Previously, we found that adiponectin (APN) suppresses IL-2–induced NK cell activation by downregulating the expression of IFN-γ–inducible TNF-related apoptosis-inducing ligand and Fas ligand. Although antitumor function APN has been reported in several types solid tumors, with few controversial results, no lymphoma studies have conducted. In this study, assessed role immune function, including cells, CTLs, myeloid-derived suppressor EL4 B16F10 tumor-bearing knockout (KO) mice. We...
The goal of this study was to investigate whether circulating C1q/TNF-α-related protein 1 (CTRP1) levels are associated with diabetes. In addition, relationships between CTRP1 and other diabetes-related cytokines were elucidated, including adiponectin fibroblast growth factor 21 (FGF21). A total 178 subjects (78 men 100 women) aged 29-70 years (mean age, 46.1 years) randomly selected. sera from a normal glucose tolerance group (n = 68) prediabetes/type 2 diabetes 110) collected; then, CTRP1,...
IK is known to inhibit the expression of major histocompatibility complex (MHC) class II antigen, but other cellular functions remain be uncovered. In this study, depletion caused misalignment chromosomes through an increase in Aurora A and PLK1 phosphorylation, which was mediated by a decrease PP1 PP2A activities. On hand, treatment dual inhibitor against CDK kinases overrode depletion‐induced mitotic arrest activation phosphatase activity. These findings imply that essential protein for...