A5021451134- Adipokines, Inflammation, and Metabolic Diseases
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Microtubule and mitosis dynamics
- Asian Culture and Media Studies
- Flavonoids in Medical Research
- Nanoparticle-Based Drug Delivery
- Adipose Tissue and Metabolism
- Genetic factors in colorectal cancer
- Immune cells in cancer
- RNA Research and Splicing
- IL-33, ST2, and ILC Pathways
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Cancer Mechanisms and Therapy
- Natural product bioactivities and synthesis
- Mast cells and histamine
- Metabolomics and Mass Spectrometry Studies
- High Altitude and Hypoxia
- Medicinal Plants and Bioactive Compounds
- Inflammatory Biomarkers in Disease Prognosis
- Pickering emulsions and particle stabilization
- Photosynthetic Processes and Mechanisms
Duksung Women's University
2020-2022
Sookmyung Women's University
2011-2021
CJ CheilJedang (South Korea)
2018
Pohang University of Science and Technology
2018
Rural Development Administration
2010
Abstract Mutation of PPP2R1A has been observed at high frequency in endometrial serous carcinomas but low ovarian clear cell carcinoma. However, the biological role mutation and cancer progression remains unclear. In this study, we found that expression is elevated high-grade primary tumor patients with papillary tumors ovary. To determine whether increased levels or might contribute to progression, effects overexpression on proliferation, migration, PP2A phosphatase activity were...
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is overexpressed in most human cancers and has been described as being involved the progression several malignancies via inhibition (PP2A) activity toward c-Myc. However, with exception this role, cellular function CIP2A remains poorly understood. On basis yeast two-hybrid coimmunoprecipitation assays, we demonstrate here that NIMA (never mitosis gene A)-related kinase 2 (NEK2) a binding partner for CIP2A. exhibited dynamic changes...
Circulating CTRP1 (C1q/TNF-α [tumor necrosis factor-α]-related protein 1) levels are increased in hypertensive patients compared with those healthy subjects. Nonetheless, little is known about the molecular and physiological function of blood pressure (BP) regulation.To investigate physiological/pathophysiological role BP regulation.CTRP1 production was to maintain normotension under dehydration conditions, this impaired inducible KO (knockout) mice (CTRP1 ΔCAG). The increase conditions...
The incidence and mortality rates of gastric cancer rank among the highest five all types worldwide. chemotherapeutic agent 5-fluorouracil (5-FU) is gold standard for treating cancer, but its efficacy limited due to high resistance. To improve therapeutic 5-FU overcome resistance, synergistic effect chrysin with was investigated mechanism elucidated. Chrysin co-administered in AGS cells 5-FU-resistant (AGS/FR). Cytotoxicity using MTT assay, followed by calculating combination index (CI)....
Abstract Previously, we found that adiponectin (APN) suppresses IL-2–induced NK cell activation by downregulating the expression of IFN-γ–inducible TNF-related apoptosis-inducing ligand and Fas ligand. Although antitumor function APN has been reported in several types solid tumors, with few controversial results, no lymphoma studies have conducted. In this study, assessed role immune function, including cells, CTLs, myeloid-derived suppressor EL4 B16F10 tumor-bearing knockout (KO) mice. We...
The epithelial-mesenchymal transition (EMT) is a hallmark of cancer metastasis, and the associated molecular signaling pathways are regarded as therapeutic targets for treatment. Thus, suppressing EMT with natural chemical compound may be benefit. Eupatolide extracted from medicinal plant Inula britannica, which used in Eastern Asia to treat bronchitis, disorders digestive system inflammation. Besides anti-inflammatory function eupatolide, present study found that eupatolide suppressed...
The goal of this study was to investigate whether circulating C1q/TNF-α-related protein 1 (CTRP1) levels are associated with diabetes. In addition, relationships between CTRP1 and other diabetes-related cytokines were elucidated, including adiponectin fibroblast growth factor 21 (FGF21). A total 178 subjects (78 men 100 women) aged 29-70 years (mean age, 46.1 years) randomly selected. sera from a normal glucose tolerance group (n = 68) prediabetes/type 2 diabetes 110) collected; then, CTRP1,...
IK is known to inhibit the expression of major histocompatibility complex (MHC) class II antigen, but other cellular functions remain be uncovered. In this study, depletion caused misalignment chromosomes through an increase in Aurora A and PLK1 phosphorylation, which was mediated by a decrease PP1 PP2A activities. On hand, treatment dual inhibitor against CDK kinases overrode depletion‐induced mitotic arrest activation phosphatase activity. These findings imply that essential protein for...
Atopic dermatitis (AD) is a type of chronic skin inflammation and one the most common relapsing allergic diseases, which presents with severe rash itchy lesions. The pathogenesis AD primarily associated hyper‑activated mast cells, makes them an effective treatment target. After cross‑linking antigen/immunoglobulin (Ig) E complex binds to its high affinity receptor FcεRl on surface cells. cells subsequently secrete excessive pro‑inflammatory mediators, including histamine cytokines, lead...
Lysimachia foenum-graecum extract (LFE) and its active component foenumoside B (FSB) have been shown to inhibit adipocyte differentiation, but their mechanisms were poorly defined. Here, we investigated the molecular responsible for anti-adipogenic effects. Both LFE FSB inhibited differentiation of 3T3-L1 preadipocytes induced by peroxisome proliferator-activated receptor-γ (PPARγ) agonists, accompanied reductions in expressions lipogenic genes aP2, CD36, FAS. Moreover, PPARγ transactivation...
Abstract IK depletion leads to an aberrant mitotic entry because of chromosomal misalignment through the enhancement Aurora B activity at interphase. Here, we demonstrate that IK, a spliceosomal component, plays crucial role in proper splicing ATM pre-mRNA among other genes related with DNA Damage Response (DDR). Intron 1 pre-mRNA, having lengths <200 bp, was not spliced IK-depleted cells and led deficiency protein. Subsequently, depletion-induced protein impaired ability repair damaged...
Gastric cancer has the fifth-highest incidence rate and is third leading cause of cancer-related deaths worldwide. The gastric higher in men than women, but for diffuse types cancer, trend opposite. Estrogen considered prime culprit behind these differences. Nevertheless, action estrogen cancers remains unclear. In this study, we investigated effect on diffuse-type cancer. Human female SNU-16 cells were transplanted into male mice to analyze endogenous tumor growth. Furthermore, exogenous...
Metastasis decreases the survival rate of patients with liver cancer. Therefore, novel anti-metastatic strategies are needed. Korean Red Ginseng (KRG) is often ingested as a functional food an immune-boosting effect. We investigated combination KRG and natural killer (NK) cells immunotherapy approach. SK-Hep1 were injected into tail vein NRGA mice to establish experimental metastasis model. KRG, NK cells, or administered. Tumor growth was observed using in vivo imaging system, metastatic...
Here, a highly selective solid-state nanocrystal conversion strategy is developed toward concave iron oxide (Fe3O4) nanocube with an open-mouthed cavity engraved exclusively on single face. The based novel heat-induced nanospace-confined domino-type migration of Fe2+ ions from the SiO2–Fe3O4 interface surrounding silica shell and concomitant self-limiting nanoscale phase-transition to Fe-silicate form. Equipped chemically unique cavity, produced Janus-type was further functionalized...
Target herbal ingredient (THI) is an extract made from two herbs, Scutellariae Radix and Platycodi Radix. It has been developed as a treatment for metabolic diseases such hyperlipidemia, atherosclerosis, hypertension. One component of these herbs reported to have anti-inflammatory, anti-hyperlipidemic, anti-obesity activities. However, there no reports about the effects mixed on diseases. In this study, we investigated THI using diet-induced obesity (DIO) mouse model. High-fat diet (HFD)...