A5102014846- Epigenetics and DNA Methylation
- Fibroblast Growth Factor Research
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
- Cancer-related Molecular Pathways
- Hippo pathway signaling and YAP/TAZ
- Pancreatic function and diabetes
- Chromatin Remodeling and Cancer
- Immune cells in cancer
- Natural product bioactivities and synthesis
- Cell death mechanisms and regulation
- Kruppel-like factors research
- Hepatocellular Carcinoma Treatment and Prognosis
- Protein Kinase Regulation and GTPase Signaling
- Retinoids in leukemia and cellular processes
- Inflammatory Biomarkers in Disease Prognosis
- Genomics, phytochemicals, and oxidative stress
- Protein Tyrosine Phosphatases
- Histone Deacetylase Inhibitors Research
- Cytokine Signaling Pathways and Interactions
Hanmi Pharmaceutical (South Korea)
2018-2025
Dongguk University
2013-2023
Marine Biodiversity Institute of Korea
2017
Dongguk University Ilsan Hospital
2015
Abstract The development of EZH1/2 inhibitors is crucial in targeting tumors due to their central role epigenetic regulation. These enzymes contribute tumorigenesis by promoting transcriptional repression tumor suppressor genes. Studies have shown that inhibiting can suppress growth and improve clinical outcomes, particularly hematological malignancies. However, the selective potency a limited range solid highlights need for precise selection indications based on molecular characteristics....
The present study aimed to determine the anticancer effect of herbal mixture extract C5E in pancreatic cancer cell line, PANC‑1, absence or presence gemcitabine treatment, a chemotherapeutic drug used for treatment cancer. effects C5E, and plus PANC‑1 cells following 72 h were investigated. each on cycle arrest, apoptosis proportion side population (SP) was determined using flow cytometric analysis propidium iodide (PI), Annexin V‑FITC/PI double staining Hoechst 33342 staining, respectively....
Hepatocellular carcinoma (HCC) is the most common type of liver cancer and responsible for 90% cases. Approximately 30% patients diagnosed with HCC are identified as displaying an aberrant expression fibroblast growth factor 19 (FGF19)–fibroblast receptor 4 (FGFR4) oncogenic-driver pathway. Therefore, control FGF19-FGFR4 signaling pathway selective FGFR4 inhibitors can be a promising therapy treatment HCC. We herein disclose design synthesis novel containing 2,6-naphthyridine scaffold....
A novel series of thieno[3,2-d]pyrimidine derivatives were synthesised and their inhibitory effects against diacylglycerol acyltransferase 1 (DGAT-1) assessed. cis-Isomer 17a showed potent selective activity DGAT-1 in SF9 cells. In addition, had an acceptable pharmacokinetic profile accumulated mainly the small intestine liver. Oral administration led to a significant reduction plasma triacylglycerol level during oral lipid tolerance test (OLTT) murine canine models. Taken together, is...
Min-Je Kim , Sae-Bom Kwon Seung Hoon Ham Eui-Suk Jeong Yang-Kyu Choi Kang Duk Jin Tae Hong Hyun Jung and Do-Young Yoon . J. Microbiol. Biotechnol. 2015;25:648-57. https://doi.org/10.4014/jmb.1501.01050
An H9 is a formula of nine medicinal herbs derived from Osuyubujaijung-tang, traditional Korean prescription for Soeumin constitution. In our previous study, showed anticancer effects against breast cancer and non-small-cell lung cancer. However, the underlying mechanisms these have not yet been elucidated. this we investigated H9, both alone in combination with trastuzumab, on cells sought to elucidate involved. suppressed proliferation human cells, induced arrest cell cycle at G0/G1 phase,...
Abstract Either enhancer of zeste homolog 2 (EZH2) or its EZH1, the enzymatic core subunit polycomb repressive complex (PRC2), acts an essential role for maintenance transcriptional repression by methylation histone H3 lysine 27 (H3K27). EZH2 gain-of-function (GOF) mutations (e.g. Y641, A677, and A687) wild-type activation cause increased activity leading to hyperinduce trimethylation H3K27 (H3K27me3). Meanwhile, loss-of-function (LOF) mutation major components ARID1A, PBRM1, INI1) in...
Parupeneus barberinus is a tropical/subtropical reef-dwelling marine fish belonging to the family Mullidae. Herein, we report first sequencing and assembly of complete mitochondrial genome P. barberinus. The 16,560 bp long has typical vertebrate gene arrangement, consisting 13 protein-coding genes, 22 tRNA two rRNA control region. Phylogenetic analysis using genomes 18 species showed that clustered with multifasciatus chrysopleuron rooted other Mullidae species. This provides potentially...
Abstract The Hippo pathway is evolutionarily conserved and known to regulate diverse cellular processes, including cell survival, proliferation, differentiation, migration, organ size. key regulator of transcriptional enhanced associate domain (TEAD) transcription factors, which directly bind with YAP/TAZ then drive the multiple signaling by activating target gene expression on nuclear. Loss-of-function mutations in upstream activators, NF2-LATS1/2-MST1/2, trigger nuclear translocation...
Abstract The Hippo pathway, a conserved signaling, modulates diverse processes including cell proliferation, survival, differentiation, organ size, and tissue homeostasis. core kinases, MST1/2 LATS1/2 phosphorylate downstream effectors, YAP/TAZ, sequestrate them in cytoplasm1). upstream regulator, NF2 activates these kinases its loss-of-function mutation leads to YAP nuclear translocation, which turn promotes tumorigenesis2). Dysregulation of pathway triggers constitutive YAP/TAZ...
Abstract Enhancer of zeste homolog 2 (EZH2), an enzymatic subunit polycomb repressive complex (PRC2), is known to catalyze tri-methylation histone H3 at lysine 27 (H3K27me3), leading repression the transcription its target genes involved in cell cycle regulation, proliferation, differentiation, and tumor suppression. It has been proposed that epigenetic regulators could serve as novel drug targets, EZH2 one targets with considerable therapeutic potential. Meanwhile, synthetic lethality a...
Abstract Protein folding homeostasis in the endoplasmic reticulum (ER) is regulated by a signaling network called unfolded protein response (UPR). Inositol-requiring enzyme 1α (IRE1α) an ER membrane-resident kinase/RNase that mediates signal transmission most evolutionarily conserved way of UPR. The IRE1α-XBP1 pathway, one essential branches UPR, activated various types cancer. When IRE1α activated, spliced form XBP1 (XBP1s) generated to activate transcription many pro-survival genes prevent...
A1E is an extract from traditional Asian medicinal plants that has therapeutic activities against cancers, metabolic disease, and other intractable conditions. However, its mechanism of action on cervical cancer not been studied. In order to ascertain if would have pronounced anti-cervical effect, cells were incubated with apoptosis was detected by nuclear morphological changes, annexin V-FITC/ PI staining, cell cycle analysis, western blotting, Reverse-transcription polymerase chain...
Abstract Introduction: Hepatocellular carcinoma (HCC) is the sixth most prevalent cancer and second frequent cause of cancer-related death, however, treatment options are very limited. In recent studies, aberrant signaling through FGFR4 its ligand, FGF19 have been identified as oncogenic driver in a subset HCCs reported to be associated with poor prognosis. About 30% HCC patients altered FGF19/FGFR4 pathway signaling, therefore, inhibitor may produce benefit. Materials Method: Using...
Abstract Chromatin remodeling is a crucial process for transcriptional regulation, of which dysregulation often observed in various human cancers. The enhancer zeste homology 2 (EZH2) and its homolog EZH1 are catalytic subunits polycomb repressive complex (PRC2), trimethylate histone H3 at lysine 27 (H3K27me3) to repress transcription target genes. Although methlytransferase activity PRC2 mainly contributed by EZH2, also conducts compensatory role maintain tri-methylation H3K27. directly...
Abstract KRAS is a well-known oncogene with the highest mutation rate among various cancers. cycles between GDP-loaded ‘off’ and GTP-loaded ‘on’ states induce downstream signal transduction to promote cell proliferation survival. Interconversion assisted by SOS (Son of sevenless), binary molecular switch KRAS. family as guanine-nucleotide exchange factor (GEF) composed SOS1 SOS2, but node in negative feedback regulation pathway while SOS2 not. Since direct upstream KRAS, inhibitor has...