A5075777692- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Osteoarthritis Treatment and Mechanisms
- Cell Adhesion Molecules Research
- Hip disorders and treatments
- Knee injuries and reconstruction techniques
- Bone and Joint Diseases
- Venous Thromboembolism Diagnosis and Management
- Shoulder Injury and Treatment
- Bone Metabolism and Diseases
- Cancer-related molecular mechanisms research
- Surgical site infection prevention
- Proteoglycans and glycosaminoglycans research
- Inflammatory mediators and NSAID effects
- Hip and Femur Fractures
- Connective tissue disorders research
- Bone health and treatments
- Tendon Structure and Treatment
- Rheumatoid Arthritis Research and Therapies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Protease and Inhibitor Mechanisms
- Bone fractures and treatments
- Bone Tissue Engineering Materials
- interferon and immune responses
University of California Davis Medical Center
2007-2018
New York University Langone Orthopedic Hospital
1999-2016
University of California, Davis
2007-2014
New York Hospital Queens
2013-2014
New York University
1998-2008
Orthopaedic Research Society
2008
York University
2006
The Orthopaedic Institute
1994-2003
University Medical Center
1999-2003
Medical Center Hospital
1999-2003
Prolonged wound drainage following total hip or knee arthroplasty has been associated with an increased risk of postoperative morbidity. The purpose this study was to determine the pharmacologic, surgical, and patient-specific factors that are prolonged relationship complication length hospital stay rate infections.We conducted a retrospective observational 1211 primary arthroplasties 1226 arthroplasties. Prospectively collected data included body mass index, intraoperative blood loss,...
Classically, osteoarthritis (OA) has been considered a noninflammatory disease. However, the detection of selected inflammatory mediators in osteoarthritic fluid, absence significant cell infiltrate, is increasingly appreciated. We sought to identify component human OA-affected cartilage that may be involved damage/destruction. Using Western blot analysis and an antibody conserved region nitric oxide synthase (NOS), we have observed up-regulation NOS, one "key players" inflammation,...
Background: The erythrocyte sedimentation rate, the C-reactive protein serum level, and white blood-cell count are routinely used to diagnose periprosthetic infection. In present study, diagnostic accuracy of interleukin-6 level was compared with these standard tests for evaluation a group patients who had total hip or knee arthroplasty were undergoing reoperation treatment an infection another implant-related problem. Methods: A prospective, case-control study fifty-eight replacement...
Background: Prolonged wound drainage following total hip or knee arthroplasty has been associated with an increased risk of postoperative morbidity. The purpose this study was to determine the pharmacologic, surgical, and patient-specific factors that are prolonged relationship complication length hospital stay rate infections. Methods: We conducted a retrospective observational 1211 primary arthroplasties 1226 arthroplasties. Prospectively collected data included body mass index,...
Arthritis is a chronic disease with significant impact on the population. It damages cartilage, synovium, and bone of joints causing pain, impairment, disability in patients. Current methods for diagnosis monitoring are only able to detect clinical manifestations arthritis late process. However, recent onset successful treatments rheumatoid osteoarthritis, it becomes important identify prognostic factors that can predict evolution arthritis. This especially critical early phases so these be...
Despite the effectiveness of a two-stage exchange protocol for treatment deep periprosthetic infection, infection can persist after resection arthroplasty and with antibiotics, leading to failed second-stage reconstruction. Intraoperative analysis frozen sections has been shown have high sensitivity specificity identification at time revision arthroplasty; however, usefulness this test reoperation antibiotics is, our knowledge, unknown.The medical records sixty-four consecutive patients who...
Degradative fragments of cartilage oligomeric matrix protein (COMP) have been observed in arthritic patients. The physiological enzyme(s) that degrade COMP, however, remain unknown. We performed a yeast two-hybrid screen (Y2H) to search for proteins associate with COMP identify an interaction partner might it. One using the epidermal growth factor (EGF) domain as bait led discovery ADAMTS-7. Rat ADAMTS-7 is composed 1595 amino acids, and this exhibits higher expression musculoskeletal...
Mutations in human cartilage oligomeric matrix protein (COMP) have been linked to the development of pseudoachondroplasia and multiple epiphyseal dysplasia; however, functions both wild-type mutant COMP skeletogenesis remain unknown. In an effort define biological COMP, a functional genetic screen based on yeast two-hybrid system was performed. This led identification granulin-epithelin precursor (GEP), autocrine growth factor, as COMP-associated partner. directly binds GEP vitro vivo,...
To quantify the concentration of superficial zone protein (SZP) in articular cartilage and synovial fluid patients with advanced osteoarthritis (OA) to further correlate SZP content friction coefficient, OA severity, levels proinflammatory cytokines.Samples were obtained from undergoing elective total knee replacement surgery. Additional normal samples donated body program tissue bank sources. Regional expression femoral condyles was quantified by enzyme-linked immunosorbent assay (ELISA)...
Currently, there is no consensus regarding the principles of empiric antibiotic treatment suspected periprosthetic infection following total knee and hip arthroplasties. This study was undertaken to attempt establish such principles.We performed a retrospective analysis 146 patients who had 194 positive cultures specimens obtained at time reoperation or arthroplasty one two institutions. Patient demographic data, comorbid conditions, bacterial species, sensitivity profile, postoperative day...
Matrix metalloproteinase (MMP)‐19 and MMP‐20 (enamelysin) are two recently discovered members of the MMP family. These enzymes involved in degradation various components extracellular matrix (ECM) during development, haemostasis pathological conditions. Whereas MMP‐19 mRNA is found widely expressed body tissues, including synovium normal rheumatoid arthritic patients, expression restricted to enamel organ. In this study we investigated ability cleave macromolecules characterising cartilage...
Abstract Objective . The migration of cells chondrocyte lineage is believed to play a role in cartilage growth and repair. present study examined 1) whether chondrocytes are capable vitro; 2) the effects nitric oxide (NO) on migration, adhesion, cytoskeletal assembly. Methods Chondrocyte was evaluated by 2 assays: “centrifugal” within 3‐dimensional collagen matrix (dot culture); directed under agarose response bone morphogenetic protein. To assess NO, were treated with either exogenous NO...
Ankylosing spondylitis is an inflammatory disease of unknown etiology that affects estimated 350,000 persons in the United States and 600,000 Europe, primarily Caucasian males second through fourth decades life. Worldwide, prevalence 0.9%. Genetic linkage to HLA-B27 has been established. axial skeleton characterized by inflammation fusion sacroiliac joints, spine, hips. The resultant deformity leads severe functional impairment approximately 30% patients. Orthopaedic management involves...