A5089432250- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Pancreatic and Hepatic Oncology Research
- Phagocytosis and Immune Regulation
- Immune Response and Inflammation
- Immune cells in cancer
- Legionella and Acanthamoeba research
- Contact Dermatitis and Allergies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Drug-Induced Adverse Reactions
- Bone and Dental Protein Studies
- Cancer Immunotherapy and Biomarkers
- Tuberculosis Research and Epidemiology
- Renal cell carcinoma treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer Cells and Metastasis
- Influenza Virus Research Studies
- Dermatology and Skin Diseases
- Glycosylation and Glycoproteins Research
- Mast cells and histamine
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
Inserm
2016-2023
Centre National de la Recherche Scientifique
2016-2023
Université Claude Bernard Lyon 1
2016-2023
Centre Léon Bérard
2022-2023
Centre de Recherche en Cancérologie de Lyon
2021-2023
Centre International de Recherche en Infectiologie
2016-2019
École Normale Supérieure de Lyon
2016-2019
Max Perutz Labs
2013-2016
University of Vienna
2013-2016
Max Planck Institute for Infection Biology
2010-2011
Secondary bacterial pneumonia leads to increased morbidity and mortality from influenza virus infections. What causes this susceptibility, however, is not well defined. Host defense infection relies only on immune resistance mechanisms but also the ability tolerate a given level of pathogen burden. Failure either or tolerance can contribute disease severity, making it hard distinguish their relative contribution. We employ coinfection mouse model Legionella pneumophila in which we separate...
Abstract Tuberculosis causes 2 million deaths per year, yet in most cases the immune response successfully contains infection and prevents disease outbreak. Induced lymphoid structures associated with pulmonary granuloma are observed during tuberculosis both humans mice could orchestrate host defense. To investigate whether perform functions, lacking secondary organs (SLO) were infected Mycobacterium (MTB). As WT mice, developed, exponential growth of MTB was controlled, antigen‐specific...
Macrophages play an important role in immune and matrix regulation during pancreatic adenocarcinoma (PDAC). Collagen deposition massively contributes to the physical functional changes of tissue pathogenesis. We investigated impact thick collagen fibers on phenotype function macrophages. recently demonstrated that extracellular protein βig-h3/TGFβi (Transforming growth factor-β-induced protein) plays modulating stiffness stroma. By using atomic force microscopy, we show βig-h3 binds type I...
Even though Mycobacterium tuberculosis (Mtb) remains one of the top microbial killers, more than 90% 2 billion infected individuals never develop active (TB), indicating efficient immune control infection in these individuals. Immune mechanisms promoting either or reactivation TB are incompletely understood. Kinetic analyses T-cell responses against Mtb C57BL/6 mice revealed surface expression inducible co-stimulatory molecule (ICOS) on >30% all CD4(+) T cells, suggesting a pivotal role this...
We report the identification of a cell population that shares pericyte, stromal and stemness features, does not harbor KrasG12D mutation drives tumoral growth in vitro vivo. term these cells pericyte stem (PeSCs) define them as CD45- EPCAM- CD29+ CD106+ CD24+ CD44+ cells. perform studies with p48-Cre;KrasG12D (KC), pdx1-Cre;KrasG12D ;Ink4a/Arffl/fl (KIC) ;p53R172H (KPC) tumor tissues from PDAC chronic pancreatitis patients. also single-cell RNAseq analysis reveal unique signature PeSC. Under...
Pathogen clearance and host resilience/tolerance to infection are both important factors in surviving an infection. Cells of the myeloid lineage play roles these processes. Neutrophils, monocytes, macrophages, dendritic cells all have initiation immune response bacterial pathogens. If not properly regulated they can result excessive inflammation immunopathology leading decreased resilience. Programmed cell death (PCD) is one possible mechanism that may use prevent inflammation. Myeloid...
Pancreatic ductal adenocarcinoma (PDAC) is associated with a vast stromal reaction that arises mainly from cancer-associated fibroblasts (CAFs) and promotes both immune escape tumor growth. Here, we used mouse model deletion of the activin A receptor ALK4 in context KrasG12D mutation, which strongly drives collagen deposition leads to tissue stiffness. By ligand-receptor analysis single-cell RNA-sequencing data, identified that, stiff conditions, neoplastic cells instructed CAFs through...
With an overall survival rate of 2-9% at 5 years, pancreatic ductal adenocarcinoma (PDAC) is currently the fourth leading cause cancer-related deaths in industrialized world and predicted to become second by 2030. Owing often late diagnosis rare actionable molecular alterations, PDAC has not yet benefited from recent therapeutic advances that immune checkpoint inhibitors (ICI) have provided other cancer types, except specific subgroups patients presenting with tumors high mutational burden...