A5101508954- Air Quality and Health Impacts
- Tuberculosis Research and Epidemiology
- Biochemical and Molecular Research
- Climate Change and Health Impacts
- Mycobacterium research and diagnosis
- Cancer therapeutics and mechanisms
- Air Quality Monitoring and Forecasting
- Parathyroid Disorders and Treatments
- RNA and protein synthesis mechanisms
- Peptidase Inhibition and Analysis
- Quinazolinone synthesis and applications
- Traditional Chinese Medicine Studies
- Magnesium in Health and Disease
- Berberine and alkaloids research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Myofascial pain diagnosis and treatment
- Colorectal Cancer Treatments and Studies
- RNA modifications and cancer
- Adenosine and Purinergic Signaling
- Geography Education and Pedagogy
- Heme Oxygenase-1 and Carbon Monoxide
- Phagocytosis and Immune Regulation
- Acupuncture Treatment Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Vitamin K Research Studies
Shenyang Medical College
2010-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2007-2021
Peking Union Medical College Hospital
2015
China Academy of Chinese Medical Sciences
2015
Institute of Medicinal Plant Development
2008
Academy of Medical Sciences
2007
Shenzhen Pingle Orthopedic Hospital
2002
Triazolothiadiazoles are potent antitubercular agents with modest inhibitory for<italic>Mt</italic>SD and without appreciable cytotoxicity.
The emergence of drug-resistant tuberculosis (TB) constitutes a major challenge to TB control programmes. There is an urgent need develop effective anti-TB drugs with novel mechanisms action. Aspartate-semialdehyde dehydrogenase (ASADH) the second enzyme in aspartate metabolic pathway. absence pathway humans and absolute requirement bacteria make ASADH highly attractive drug target. In this study, we used coupled Escherichia coli type III kinase (LysC) establish high-throughput screening...
Matrix Gla protein (MGP), a potent calcification inhibitor in extracellular matrix, is molecular determinant regulating vascular calcification. Here, we characterized MGP expression cultured renal tubular epithelial cells exposed to oxalate and calcium monohydrate (COM) crystals.NRK-52E were medium containing or COM for 1, 3, 6, 12 24 h. The levels of mRNA quantified using real-time PCR (RT-PCR), the by Western blot.MGP was expressed rapidly intensively following exposure time-dependent with...
Background: The aim of this study was to investigate the overall impact PM2.5, PM10, NO2, SO2, CO, and O3 on admission cardiovascular cerebrovascular disease. Methods: We collected data disease admissions from two hospitals in Shenyang Liaoning, China Jan 2014 Dec 2017, as well daily measurements six pollutants at 11 sites Shenyang. generalized additive model used assess association between contaminants Results: single-contamination showed a significant correlation O3, PM10 diseases lag0...
Aspartic acid semialdehyde dehydrogenase (ASADH) lies at the first branch point in essential aspartic biosynthetic pathway that is found bacteria and plants but absent from animals. Mutations asadh gene encoding ASADH produce an inactive enzyme, which lethal. Therefore, this study, we investigated hypothesis represents a new anti-Mycobacterium tuberculosis (MTB) target. An promoter-replacement mutant MTB, designated MTB::asadh, expression regulated by pristinamycin, was constructed to...
Flavonoids which are extracted from citrus peel and pulp have been reported to multiple beneficial effects on human health. Isosinensetin (ISO) is a type of flavonoid compound, has several protective including anticancer, antioxidant, antiviral, anti-inflammatory bacteriostatic. However, the molecular mechanism its antioxidant remain unclear. The present study aimed investigate intervention effect possible ISO bronchial epithelial cells injured by fine particular matter ≤2.5 µm in diameter...
The aim of the study was to find out association between air pollution and meteorological conditions with death residents living in Shenyang due malignant tumors. Tumor related data five urban districts were obtained from Center for Disease Control Prevention. Daily temperature, pressure, wind speed humidity 2010 2015 Meteorological Bureau. Urban Environmental Monitoring Station, Protection Bureau China. All analyzed by Poisson regression model. During period 2015, number deaths among...
Culturing sientific research ability and innovative of medical college students is important for the development themselves colleges as well,which also meets needs local economy social development.This paper studies undergraduate projects in recent five years,to underst tmedical students' ability.Countermeasures are proposed to improve situation. Key words: Medical students; Research project; Innovative