A5080214955- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Biosimilars and Bioanalytical Methods
- Bacterial Identification and Susceptibility Testing
- Antibiotics Pharmacokinetics and Efficacy
- Drug-Induced Adverse Reactions
Chinese University of Hong Kong
2023
University of Hong Kong
2022-2023
Antibiotics are widely used for the treatment of bacterial infections. However, injudicious use antibiotics based on an empirical method may lead to emergence resistant strains. Despite appropriate administration antibiotics, their concentrations remain subinhibitory in body, due individual variations tissue distribution and metabolism rates. This promote virulence complicate strategies. To investigate whether certain classes will induce worsen infection under vivo conditions. Different were...
Antibiotic tolerance poses a threat to current antimicrobial armamentarium. Bacteria at tolerant state survive in the presence of antibiotic treatment and account for persistence, relapse recalcitrance infections. failure may occur due tolerance. Persistent infections are difficult treat often associated with poor prognosis, imposing an enormous burden on healthcare system. Effective strategies targeting antibiotic-tolerant bacteria therefore highly warranted. In this study, small molecule...
Staphylococcus aureus can cause a plethora of life-threatening infections. Antibiotics have been extensively used to treat S. However, when antibiotics are at sub-inhibitory concentrations, especially for β-lactam antibiotics, they may enhance staphylococcal pathogenicity and exacerbate the infection. The combination antivirulence agents be novel approach controlling antibiotic-induced pathogenicity. We illustrated that under in vitro conditions, agent M21, administered concurrently with...