A5033459242- Neuroendocrine Tumor Research Advances
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Lung Cancer Research Studies
- Bacterial Genetics and Biotechnology
- Genetic factors in colorectal cancer
- Esophageal Cancer Research and Treatment
- Neuroblastoma Research and Treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Cancer Immunotherapy and Biomarkers
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Antibiotic Resistance in Bacteria
- Cancer Genomics and Diagnostics
- Colorectal Cancer Screening and Detection
- Bacteriophages and microbial interactions
- DNA Repair Mechanisms
- Lung Cancer Treatments and Mutations
- RNA Interference and Gene Delivery
- Helicobacter pylori-related gastroenterology studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Medical Imaging and Pathology Studies
- Pleural and Pulmonary Diseases
Fundacion Favaloro Hospital Universitario
2012-2025
Instituto de Oncología de Rosario
2025
Hôpital Foch
2024
Assistance Publique – Hôpitaux de Paris
2024
Institut Català d'Oncologia
2015-2024
Universitat Autònoma de Barcelona
2024
Sorbonne Université
2024
Aix-Marseille Université
2024
Hôpital Saint-Antoine
2024
Favaloro Foundation
2019-2021
No adjuvant treatment has been established for patients who remain at high risk recurrence after neoadjuvant chemoradiotherapy and surgery esophageal or gastroesophageal junction cancer.
LBA768 Background: Patients (pts) with MSI-H/dMMR mCRC have poor outcomes standard chemo ± targeted therapies. NIVO IPI are approved in previously treated pts many countries, based on the phase 2 CheckMate 142 study. 8HW (NCT04008030) is a randomized 3 study comparing + or mCRC. We report progression-free survival (PFS) by blinded independent central review (BICR) at prespecified interim analysis for vs 1L setting. Methods: Pts ≥ 18 years recurrent not amenable to surgery and status per...
BackgroundPatients with microsatellite-instability–high (MSI-H) or mismatch-repair–deficient (dMMR) metastatic colorectal cancer have poor outcomes standard chemotherapy without targeted therapies. Nivolumab plus ipilimumab has shown clinical benefit in nonrandomized studies of MSI-H dMMR cancer.MethodsIn this phase 3 open-label trial, we randomly assigned patients unresectable and status according to local testing receive, a 2:2:1 ratio, nivolumab ipilimumab, alone, The dual primary end...
The progenitors of the gametes, primordial germ cells (PGCs) are typically specified early in development positions, which distinct from gonad. These then migrate toward gonad where they differentiate into sperms and eggs. Here, we study role somatic particularly line sex differentiation zebrafish. To this end, ablated using two independent methods followed experimental fish. First, PGCs were by knocking down function dead end , a gene important for survival lineage. Second, method to...
Open-label phase II study (RELATIVITY-060) to investigate the efficacy and safety of first-line nivolumab, a PD-1-blocking antibody, plus relatlimab, lymphocyte-activation gene 3 (LAG-3)-blocking chemotherapy in patients with previously untreated advanced gastric cancer (GC) or gastroesophageal junction (GEJC).
3503 Background: NIVO + IPI demonstrated superior progression-free survival (PFS) vs chemo in patients (pts) with previously untreated MSI-H/dMMR mCRC the randomized phase 3 CheckMate 8HW study (NCT04008030). We report expanded efficacy analysis from prespecified interim of 1L setting. Methods: Pts unresectable or and status by local testing were enrolled across different lines therapy 2:2:1 to (240 mg) (1 mg/kg) Q3W (4 doses, then 480 mg Q4W), Q2W (6 ± targeted therapies; treatments...
Neuroendocrine tumors (NET) include a spectrum of malignancies arising from neuroendocrine cells throughout the body. The objective this clinical investigation retrospectively and prospectively collected data was to describe prevalence, demographic data, symptoms methods diagnosis NET treatment long-term follow-up patients with NET. Data were provided by participating centers assessed for consistency internal reviewers. All cases centrally evaluated (when necessary) pathologists in our...
Background/Objectives: BRAF-mutation is a poor prognostic factor in colorectal cancer (CRC). There need for real-world data low-middle-income countries regarding clinical characteristics, outcomes, and treatment strategies. This study aims to describe progression free survival (PFS) overall (OS) the first-line setting, sequences of regimens. Methods: We retrospective analyze patients from ten oncology centers Argentina, diagnosed with BRAFV600E-mutated advanced CRC between January 2014 July...
LBA143 Background: The CheckMate 8HW study met its dual primary endpoint with NIVO + IPI demonstrating superior progression-free survival (PFS) by blinded independent central review (BICR) vs chemotherapy (chemo) in patients (pts) centrally confirmed MSI-H/dMMR mCRC the first-line (1L) setting (HR 0.21; 95% CI 0.14–0.32; P < 0.0001). We report first results from other of PFS for across all lines therapy pts mCRC. Methods: Immunotherapy-naive unresectable or and status local testing who...
Background/Objectives: The BRAF-mutation is a poor prognostic factor in colorectal cancer (CRC). There need for real-world data low-middle-income countries regarding clinical characteristics, outcomes, and treatment strategies. This study aims to describe progression-free survival (PFS) the first- second-line setting sequences of regimens. Methods: We retrospectively analyze patients from ten oncology centers Argentina, diagnosed with BRAFV600E-mutated advanced CRC between January 2014 July...
<b>Background:</b> Retinoic acid (RA) is a powerful differentiation agent. Barrett's oesophagus occurs when duodeno-gastro-oesophageal reflux causes squamous epithelium (SE) tissue to become columnar by an unknown mechanism. The bile lithocholic (LCA) competes for the retinoid X receptor binding site. Hence, RA pathways may be implicated in oesophagus. <b>Methods:</b> activity tissues and cell lines treated with all<i>-trans</i> retinoic (ATRA) or without LCA was assessed using reporter....
The development of superparamagnetic iron oxide nanoparticle (SPION)-based diagnostic and therapeutic nanosystems holds a promise revolutionizing biomedicine, helping to solve important unmet clinical needs. Such potential will only be fulfilled if appropriate methods for SPION production their subsequent tailoring specific applications are established, something that remains challenging. Here, we report simple low cost method fabricate structurally colloidally ultrastable, water soluble...
Lynch syndrome is the most common cause of hereditary colorectal cancer (CRC), and it characterized by DNA mismatch repair (MMR) deficiency. The term Lynch-like (LLS) used for patients with MMR-deficient tumors neither germline mutation in MLH1, MSH2, MSH6, PMS2, or EPCAM nor MLH1 somatic methylation. Biallelic inactivation cryptic MMR variants undetected during genetic testing have been proposed to be involved. Sixteen early-onset LLS CRC were selected tumor whole-exome sequencing. Two...
Early‐onset (<50 years‐old) nonpolyposis nonfamilial colorectal cancer (EO NP NF CRC) is a common clinical challenge. Although Lynch syndrome (LS) associated with EO CRC, the frequency of this in cases remains unknown. Besides, mismatch repair deficient (MMRd) CRCs negative MMR gene testing have recently been described up to 60% and termed “Lynch‐like syndrome” (LLS). Management counseling decisions these patients are complicated because unconfirmed suspicions hereditary cancer. To define...
Anal squamous cell carcinoma (ASCC) is a rare gastrointestinal malignancy associated with high-risk Human papillomavirus (HPV) infection. Despite improved outcomes in non-metastatic ASCC, definitive chemoradiotherapy constitutes the standard treatment for localized disease. Evidences predictive and prognostic biomarkers are limited. Here, we performed viral, immune, mutational characterization of 79 ASCC patients complete chemoradiotherapy. HPV-16 was detected 91% positive cases single...
The fabrication of colloidal nanocomposites would benefit from controlled hetero-assembly ready-made particles through covalent bonding. Here we used epoxy-amine coupling chemistry to promote the self-assembly superparamagnetic raspberry-like nanocomposites. This adaptable method induced attachment iron oxide nanoparticles sparsely coated with amine groups onto epoxylated silica cores in absence other reactants.