A5019952974- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Surgical Treatments
- Clinical Nutrition and Gastroenterology
- Neuroendocrine Tumor Research Advances
- Colorectal and Anal Carcinomas
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Neuroblastoma Research and Treatments
- Celiac Disease Research and Management
- Inflammatory Bowel Disease
- Genetic factors in colorectal cancer
- Gastrointestinal disorders and treatments
- Organ Transplantation Techniques and Outcomes
- Microscopic Colitis
- Colorectal Cancer Treatments and Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Diagnosis and treatment of tuberculosis
- Appendicitis Diagnosis and Management
- Cardiac Ischemia and Reperfusion
- Case Reports on Hematomas
- Galectins and Cancer Biology
- Cancer Genomics and Diagnostics
- Digestive system and related health
- Gastric Cancer Management and Outcomes
- Gastrointestinal motility and disorders
Fundacion Favaloro Hospital Universitario
2010-2022
Instituto de Gastroenterología
2022
Favaloro University
2012-2021
Consejo Nacional de Investigaciones Científicas y Técnicas
2017
Early-onset colorectal cancer (CRC) represents a clinically distinct form of CRC that is often associated with poor prognosis. Methylation levels genomic repeats such as LINE-1 elements have been recognized independent factors for increased cancer-related mortality. The methylation status in early-onset has not analyzed previously.We 343 tissues and 32 normal colonic mucosa samples, including 2 cohorts diagnosed ≤ 50 years old (n=188), group sporadic >50 (MSS n=89; MSI n=46), Lynch syndrome...
Chagas disease frequently causes megacolon. We investigated the enteric nervous systems in patients with chagasic megacolon compared to idiopathic and controls. Surgical specimens were obtained from 12 (1 woman, 11 men, age range 41 72 y) 9 (3 women, 6 39 68 y), undergoing surgery for intractable constipation. A control group of 10 (9 1 man, 43 75 left hemicolectomy nonobstructing colorectal cancer was also studied. Colonic sections by conventional immunohistochemical methods, taking into...
Abstract Purpose: No biomarker to personalize treatment in locally advanced rectal cancer (LARC) is currently available. We assessed LARC whether a diagnostic biopsy-adapted immunoscore (ISB) could predict response neoadjuvant (nT) and better define patients eligible an organ preservation strategy (“Watch-and-Wait”). Experimental Design: Biopsies from two independent cohorts (n1 = 131, n2 118) of with treated nT followed by radical surgery were immunostained for CD3+ CD8+ T cells quantified...
Background: Pouchitis has been suggested to be a recurrence of ulcerative colitis in colon‐like mucosa. Topical steroids are valid therapeutic alternative for distal forms colitis. Aim: To investigate the efficacy and tolerability budesonide enema treatment pouchitis compared with oral metronidazole. Materials methods: Twenty‐six patients an active episode (defined as disease activity index score ≥ 7) no during previous month were randomized receive either (2 mg/100 mL at bedtime) plus...
Neuroendocrine tumors (NET) include a spectrum of malignancies arising from neuroendocrine cells throughout the body. The objective this clinical investigation retrospectively and prospectively collected data was to describe prevalence, demographic data, symptoms methods diagnosis NET treatment long-term follow-up patients with NET. Data were provided by participating centers assessed for consistency internal reviewers. All cases centrally evaluated (when necessary) pathologists in our...
We have previously shown a reduction of gastrointestinal symptoms after the oral administration Bifidobacterium infantis Natren Life Start super strain (NLS-SS) in untreated celiac disease (CD) patients. The symptomatic improvement was not associated with changes intestinal permeability or serum levels cytokines, chemokines, growth factors. Therefore, we hypothesized that beneficial effect observed patients CD treated B. may be related to modulation innate immunity.To investigate potential...
Galectins, a family of animal lectins characterized by their affinity for N-acetyllactosamine-enriched glycoconjugates, modulate several immune cell processes shaping the course innate and adaptive responses. Through interaction with wide range glycosylated receptors bearing complex branched N-glycans core 2-O-glycans, these endogenous trigger distinct signaling programs thereby controling activation, differentiation, recruitment survival. Given unique features mucosal inflammation...
Anal squamous cell carcinoma (ASCC) is a rare gastrointestinal malignancy associated with high-risk Human papillomavirus (HPV) infection. Despite improved outcomes in non-metastatic ASCC, definitive chemoradiotherapy constitutes the standard treatment for localized disease. Evidences predictive and prognostic biomarkers are limited. Here, we performed viral, immune, mutational characterization of 79 ASCC patients complete chemoradiotherapy. HPV-16 was detected 91% positive cases single...
AIMTo evaluate the association of Helicobacter pylori (H.pylori ), cagA genotype, and type gastric pathology with ghrelin, leptin nutritional status.pathology are associated lower serum ghrelin.Further studies could confirm a ghrelin prevalence in -positive patients.
Locally advanced rectal cancer (LARC) remains a medical challenge. Reliable biomarkers to predict which patients will significantly respond neoadjuvant chemoradiotherapy (nCRT) have not been identified. We evaluated baseline genomic and transcriptomic features detect differences that may help response nCRT. Eligible LARC received nCRT (3D-LCRT 50.4 Gy plus capecitabine 825 mg/m2/bid), preceded by three cycles of CAPOX in high systemic-relapse risk tumors, subsequent surgery. Frozen tumor...
Rectal Cancer (RC) is a complex disease that involves highly variable treatment responses. Currently, there lack of reliable markers beyond TNM to deliver personalized in cancer setting where the goal curative treatment. Here, we performed an integrated characterization predictive and prognostic role clinical features, mismatch-repair deficiency markers, HER2, CDX2, PD-L1 expression, CD3 − CD8 + tumor-infiltrating lymphocytes (TILs) coupled with targeted DNA sequencing 76 non-metastatic RC...
Background : Intestinal failure–associated liver disease (IFALD) is a frequent indication for intestinal transplantation. Liver biopsy (LBX) the gold standard test its diagnosis. Identifying noninvasive markers of fibrosis progression would be considerable clinical use. Aspartate aminotransferase/platelet ratio index (APRI) has good correlation in adult patients with chronic disease; few studies have been performed children IFALD. Aim To evaluate APRI cohort Materials and Methods...
Background Intestinal transplantation (ITx) faces many challenges due to the complexity of surgery and multiple immunological reactions that lead necessity rigorous follow-up for early detection acute cellular rejection (ACR). Our aim was determine kinetics ACR using an experimental ITx model, with emphasis in characterization process different approaches, including use functional assays absorptive barrier function. Methods rats conducting serial sampling performed. Clinical monitoring,...
Acute cellular rejection (ACR) and infections are leading causes of graft loss death in intestinal transplant patients. Our aim was to evaluate the impact maintenance immunosuppressive therapies on expression pro-inflammatory mediators small bowel at ACR diagnosis.We analyzed levels Th1-associated genes, IFNG, CXCL10, CXCL11 by qPCR 46 selected biopsies unequivocally assigned mild (n = 14) or normal histopathology clinical condition 32) from 15 patients receiving two different (IS) schemes....
Kaposi's sarcoma (KS) is an infrequent vascular neoplasm commonly diagnosed as isolated cutaneous lesion that can involve other organs. So far, there are no data in the literature about development of KS after intestinal transplant.In this study, authors describe a case "visceral KS" with pulmonary and involvement perform systematic review reports single-center series identified MEDLINE.This was 42-year-old man, visceral 9 months receiving transplant. He successfully treated combination...
Abstract Exfoliative rejection is a severe complication after intestinal transplant. The assessment of mucosa histology restricted to the area reached by endoscopy. We aim evaluate serum albumin ( SA ) value as parameter graft damage and clinical prognosis in exfoliative E x R ). present study retrospective analysis 11 episodes occurred cohort 26 patients. levels were measured 24 h diagnosis twice week thereafter then correlated with parameters histological recovery HR During , all patients...
Intestinal transplantation (IT) faces many challenges, among them, the necessity to early detect rejection processes. Rodent models of IT are used provide evidence for intervention strategies as well improve knowledge small bowel transplant biology. The aim our study was determine kinetics using a Heterotopic (HIT) model, with emphasis in characterization process different approaches, including use simple functional assays absorptive and barrier function evaluation that could be eventually...