A5101754856- Cervical Cancer and HPV Research
- Polyomavirus and related diseases
- Oral Health Pathology and Treatment
- Head and Neck Cancer Studies
- NF-κB Signaling Pathways
- Latin American Urban Studies
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Effects and risks of endocrine disrupting chemicals
- Pesticide and Herbicide Environmental Studies
- Genomics, phytochemicals, and oxidative stress
- Mining and Resource Management
- Lung Cancer Research Studies
- Spanish Philosophy and Literature
- Herpesvirus Infections and Treatments
- Chemokine receptors and signaling
- T-cell and Retrovirus Studies
- Bioactive Compounds and Antitumor Agents
- Agriculture and Rural Development Research
- Latin American socio-political dynamics
- Cancer Cells and Metastasis
- Antenna Design and Analysis
- Breast Cancer Treatment Studies
- Neuroblastoma Research and Treatments
- Weed Control and Herbicide Applications
University of Tarapacá
2020-2025
Hospital Sant Joan de Déu Barcelona
2024-2025
Clínica MEDS (Chile)
2025
University of Chile
2012-2021
San Sebastián University
2021
Pontificia Universidad Católica de Chile
2018
El Colegio de México
2003
Universitat de Lleida
1999
Chagas disease frequently causes megacolon. We investigated the enteric nervous systems in patients with chagasic megacolon compared to idiopathic and controls. Surgical specimens were obtained from 12 (1 woman, 11 men, age range 41 72 y) 9 (3 women, 6 39 68 y), undergoing surgery for intractable constipation. A control group of 10 (9 1 man, 43 75 left hemicolectomy nonobstructing colorectal cancer was also studied. Colonic sections by conventional immunohistochemical methods, taking into...
High-dose chemotherapy with autologous stem cell rescue has improved outcomes in patients metastatic retinoblastoma (RB). Despite significant advances, acute and long-term side-effects, particularly visually impaired cancer-predisposed patients, underscore the need for additional treatment options. Monoclonal antibodies (mAbs) directed against tumor-associated antigen GD2 are of considerable interest. Additional lines RB research include tracking minimal disseminated disease (MDD) to permit...
Abstract Protein kinase CK2 is a highly conserved and constitutively active Ser/Thr-kinase that phosphorylates large number of substrates, resulting in increased cell proliferation survival. A known target Akt, player the PI3K/Akt/mTORC1 signaling pathway, which aberrantly activated 32% colorectal cancer (CRC) patients. On other hand, mTORC1 plays an important role regulation protein synthesis, growth, autophagy. Some studies suggest regulates several cancers. The most recently developed...
Social movements have been viewed as vehicles through which the concerns of poor and marginalised groups are given greater visibility within civil society, lauded for being means to achieve local empowerment citizen activism, seen essential in holding state account constituting a grassroots mechanism promoting democracy. However, development studies little attention has paid understanding how social can affect trajectories rural livelihood spaces, these effects related movements' internal...
AbstractThe present research proposes a genealogical exercise concerning Chilean architecture based on the body of projects selected at 2019 Architecture Biennial. Such an will allow us not only to identify main sources declared by local architects but also discuss notion "reference" itself and its reach in field architecture. Thus, we approach space where tension is present, explicit declarations share room with omissions, buildings well-known authors anonymous All this takes place...
Glioblastoma (GB) is a highly malignant brain tumor with poor prognosis, median survival of only 14.6 months despite aggressive treatments. Resistance to chemotherapy, particularly temozolomide (TMZ), significant challenge. The DNA repair enzyme MGMT and glioblastoma stem cells (GSCs) often mediate this resistance. Recent studies highlight the therapeutic potential natural compounds, delphinidins, found in deep purple berries. Delphinidins are known for their ability inhibit NF-κB signaling,...
Background: Breast cancer is the most commonly diagnosed among women, and resistance to chemotherapy presents a significant challenge in its treatment. Stanniocalcin-2 (STC2), glycoprotein involved calcium homeostasis cellular stress responses, frequently overexpressed various human cancers. Despite critical role adaptation stress, potential of STC2 as biomarker for predicting response has not been evaluated. This study aimed assess predictive breast cancer. Methods: We utilized publicly...
Achilles tendon ruptures are commonly managed with surgical repair, often using non-absorbable sutures for their tensile strength. However, foreign body reactions have been increasingly reported, accounting up to 2% of complications in some studies, compared approximately 3% wound dehiscence. We present two cases biopsy-proven following percutaneous repair FiberWire® (Arthrex, Naples, Florida) sutures. Both patients developed localized swelling and erythema months after surgery, without any...
High-risk human papillomavirus (HR-HPV) infection is not a sufficient condition for cervical cancer development because most infections are benign and naturally cleared. Epidemiological studies revealed that tobacco smoking cofactor with HR-HPV initiation progression, even though the mechanism by which smoke cooperates in this malignancy poorly understood. As E6/E7 oncoproteins overexpressed carcinomas colocalize cigarette components (CSC), study we addressed signaling pathways involved...
4124 Background: To evaluate EGFR polymorphisms as predictors of clinical outcome in patients (pts) with ACRC treated cetuximab or panitumumab. Methods: 84 pts who received panitumumab second and third line therapy were included. We analyze three polyphormisms: a single nucleotide polymorphism (SNP) codon 216 (216 G/T), SNP 497 (497 G/A), dinucleotide repeat intron 1. DNA was extracted from paraffin-embedded tissue using the QiaAmp Mini kit. The sAVH3, - 216G>T R497K genotyped each pts. In...
We have previously shown a functional interaction between human papillomavirus type 16 (HPV-16) E6 and E7 oncoproteins cigarette smoke condensate (CSC) in lung cells suggesting cooperation during carcinogenesis. The molecular mechanisms of such interaction, however, remain to be elucidated. Here we first present evidence showing that has the ability activate HPV-16 p97 promoter by acting on long control region (LCR) epithelial cells. Interestingly, observed CSC-induced activation occurs...
A subset of oral carcinomas is etiologically related to high-risk human papillomavirus (HR-HPV) infection, with HPV16 being the most frequent HR-HPV type found in these carcinomas. The oncogenic role strongly dependent on overexpression E6 and E7 oncoproteins, which, turn, induce p53 pRb degradation, respectively. Additionally, it has been suggested that oncoproteins are involved regulation nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB), inducing cancer progression...