A5041445575- Clinical Nutrition and Gastroenterology
- Organ Transplantation Techniques and Outcomes
- Probiotics and Fermented Foods
- Celiac Disease Research and Management
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Gut microbiota and health
- Microscopic Colitis
- Digestive system and related health
- Cardiac Ischemia and Reperfusion
- Protein Hydrolysis and Bioactive Peptides
- Organ Donation and Transplantation
- Diet and metabolism studies
- Anesthesia and Neurotoxicity Research
- Viral gastroenteritis research and epidemiology
- Microbial Metabolites in Food Biotechnology
- Microbial Inactivation Methods
- Mesenchymal stem cell research
- Escherichia coli research studies
- Organ and Tissue Transplantation Research
- Wheat and Barley Genetics and Pathology
- Animal Disease Management and Epidemiology
- Plant tissue culture and regeneration
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Veterinary Pharmacology and Anesthesia
Consejo Nacional de Investigaciones Científicas y Técnicas
2016-2025
Universidad Nacional de La Plata
2015-2025
Exact Sciences (United States)
2020
Centro de Investigación y Desarrollo en Criotecnología de Alimentos
1996-2020
Instituto de Física La Plata
2015-2020
Centro Científico Tecnológico - La Plata
2019
Favaloro University
2017-2018
Hospital General de Niños Ricardo Gutierrez
1999
Transgenic plants are attractive biological systems for the large-scale production of pharmaceutical proteins. In particular, seeds offer special advantages, such as ease handling and long-term stable storage. Nevertheless, most studies expression antibodies in have been performed leaves. We report a secreted (sec-Ab) or KDEL-tagged (Ab-KDEL) mutant 14D9 monoclonal antibody transgenic tobacco leaves seeds. Although KDEL sequence has little effect on accumulation leaves, it leads to higher...
Lactate is an essential component of carbon metabolism in mammals. Recently, lactate was shown to signal through the G protein coupled receptor 81 (GPR81) and thus modulate inflammatory processes. This study demonstrates that inhibits pro-inflammatory signaling a GPR81-independent fashion. While lipopolysaccharide (LPS) triggered expression IL-6 IL-12 p40, CD40 bone marrow-derived macrophages, able abrogate these responses dose dependent manner Gpr81-/- cells as well wild type cells....
Although it has been traditionally regarded as an intermediate of carbon metabolism and major component fermented dairy products contributing to organoleptic antimicrobial properties food, there is evidence gathered in recent years that lactate bioactive may be responsible broader functional foods. Lactate can regulate critical functions several key players the immune system such macrophages dendritic cells, being able modulate inflammatory activation epithelial cells well. Intraluminal...
Lactate has long been considered as a metabolic by-product of cells. Recently, this view changed by the observation that lactate can act signaling molecule and regulates critical functions immune system. We previously identified component responsible for modulation innate epithelial response fermented milk supernatants in vitro. have also shown downregulates proinflammatory responses macrophages dendritic So far, vivo effects on intestinal inflammation not reported. evaluated effect...
Inflammatory bowel diseases (IBDs) are complex affections with increasing incidence worldwide. Multiple factors involved in the development and maintenance of symptoms including enhanced oxidative stress intestinal mucosa. The conventional therapeutic approaches for IBDs based on use anti-inflammatory drugs important collateral effects partial efficacy. In present work we tested capacity Kluyveromyces marxianus CIDCA 8154 different models . vitro, showed that pretreatment epithelial cells...
Outer Membrane Vesicles (OMVs) derived from different Gram-negative bacteria have been proposed as an attractive vaccine platform because of their own immunogenic adjuvant properties. Pertussis or whooping cough is a highly contagious vaccine-preventable respiratory disease that resurged during the last decades in many countries. In response to epidemiologic situation new, incorporated boosters into vaccination schedules and new candidates started be designed. Particularly, our group...
Background Intestinal transplantation (ITx) represents the only curative option for patients with irreversible intestinal failure. Nevertheless, its rejection rate surpasses that of other solid organ transplants due to heightened immunological load gut. Regulatory T-cells (Tregs) are key players in induction and maintenance peripheral tolerance, suggesting their potential involvement modulating host vs . graft responses after ITx. Thus, we investigated association Tregs allograft outcomes...
AbstractBackground: Secretion of dietary antigens into breast milk has been extensively documented. The presence these is relevance because they could be involved in the modulation immune response neonates. objective this study to determine gliadin concentration milk, colostrum, and serum samples from healthy lactating mothers on a normal diet. Gliadin levels group six after brief period gluten restriction were also determined. molecular weight secreted gliadins was analysed. Methods:...
Abstract Background The criteria for choosing relevant cell lines among a vast panel of available intestinal-derived exhibiting wide range functional properties are still ill-defined. objective this study was, therefore, to establish assess their appropriateness as tumor models well drug absorption studies. Results We made use publicly expression signatures and based assays delineate differences between various intestinal colon carcinoma normal epithelium. have compared with patient-derived...
Protein detection to certify foodstuff composition is frequently accomplished by immunochemical methods. Product processing (heating, pH change, etc.) usually alters protein structure and can modify reactivity of the protein. We studied structural changes caused heating ovalbumin under different time temperature conditions influence heat on ovalbumin. Differential scanning calorimetry (DSC), exposed sulfhydryl groups, surface hydrophobicity (Ho) were used evaluate changes. The was measured...
Enterohemorrhagic Escherichia coli (EHEC) infections can result in a wide range of clinical presentations despite that EHEC strains belong to the O157:H7 serotype, one most pathogenic forms. Although pathogen virulence influences disease outcome, we emphasize concept host-pathogen interactions, which involve resistance or tolerance mechanisms host determine total fitness and bacterial virulence. Taking advantage genetic differences between mouse strains, analyzed progression C57BL/6 BALB/c...
Severe cases of Coronavirus Disease 2019 (COVID-19) that require admission to the Intensive Care Unit (ICU) and mechanical ventilation assistance show a high mortality rate with currently few therapeutic options available. COVID-19 is characterized by systemic inflammatory condition, also called "cytokine storm", which can lead various multi-organ complications ultimately death. Lidocaine, safe local anesthetic given intravenously used treat arrhythmias, has long been reported have an...