A5058543364- Clinical Nutrition and Gastroenterology
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Congenital Anomalies and Fetal Surgery
- Hematopoietic Stem Cell Transplantation
- Organ and Tissue Transplantation Research
- Stroke Rehabilitation and Recovery
- Organ Donation and Transplantation
- Liver Disease and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Appendicitis Diagnosis and Management
- Transplantation: Methods and Outcomes
- Intestinal Malrotation and Obstruction Disorders
- Advanced Battery Technologies Research
- Pectus Deformity Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Congenital Diaphragmatic Hernia Studies
- Amoebic Infections and Treatments
- COVID-19 Clinical Research Studies
- Cerebral Palsy and Movement Disorders
- Biomedical Ethics and Regulation
- Immune Cell Function and Interaction
- Hepatocellular Carcinoma Treatment and Prognosis
- Electric Vehicles and Infrastructure
- Acute Ischemic Stroke Management
Hospital Universitario La Paz
2018-2025
Hospital La Paz Institute for Health Research
2020-2025
Temple Street Children's University Hospital
2021
Children's Hospital
2021
Newcastle University
2011-2017
To date, real cost data for Electric Vehicle (EV) rapid charging infrastructure is largely missing in the literature, preventing development of economic models to encourage private investment and limiting policy decisions. A business model has been constructed using actual capital expenditure, operating costs usage from Rapid Charge Network project (RCN) which can be used assist future The run under a wide spectrum EV uptake scenarios provide plausible answers variety research, questions,...
Background Intestinal transplantation (ITx) represents the only curative option for patients with irreversible intestinal failure. Nevertheless, its rejection rate surpasses that of other solid organ transplants due to heightened immunological load gut. Regulatory T-cells (Tregs) are key players in induction and maintenance peripheral tolerance, suggesting their potential involvement modulating host vs . graft responses after ITx. Thus, we investigated association Tregs allograft outcomes...
The current shortage of pediatric multivisceral donors accounts for the long time and mortality on waiting list patients. use after cardiac death, especially outbreak normothermic regional perfusion, has increased in recent years all solid organs except intestine, mainly because its higher susceptibility to ischemia-reperfusion injury. We present first literature case death transplantation a 13-month-old recipient from 2.5-month-old donor. Once exitus was certified, an extracorporeal...
We present an evaluation of the cross-sectional and longitudinal validity (sensitivity to change) a new algorithm assess upper limb function generated automatically during play bespoke, professionally-written action video game (Circus Challenge Assessment Game, CCAG). The subjects were 33 patients with hemiplegia after stroke (aged 33-81 years), who played CCAG on 8 separate occasions over 12 week period; 19 in chronic phase stroke, stable function; 14 acute recovery function. A convergent...
There is an urgent need to address the shortage of potential multivisceral grafts in order reduce average time waiting list. Since donation after circulatory death (DCD) has been successfully employed for other solid organs, a thorough evaluation use intestinal from DCD warranted. Here, we have generated model Maastricht III rodents, focusing on viability and at five (DCD5) twenty (DCD20) minutes cardiac arrest compared living brain donors. groups exhibited time-dependent damage. DCD20...
Background Donor-specific anti-HLA antibodies (DSA) impact negatively on the outcome of intestinal grafts. Although use antibody-removal therapies (ART) is becoming more frequent in last few years, issues regarding their timing and effectiveness remain under discussion. Methods In present study, we report our experience with eight ART procedures (based plasmapheresis, intravenous immunoglobulin, rituximab) pediatric multivisceral transplants de novo DSA (dnDSA). Results were performed when...
Objective: We aimed to assess whether native spleen preservation during visceral transplantation (VT) affects graft-versus-host-disease (GVHD) incidence. Summary Background Data: GVHD is one of the most severe and frequently lethal hematological complications after VT procedures. Because there no specific treatment for GVHD, it imperative develop a strategy reduce donor lymphocyte engraftment proliferation. Methods: Our study included both clinical experimental data. A total 108 patients...
We report a 12-day-old male who was admitted with vomiting because of an unusual early complication Marfan's syndrome (MS): sliding hiatal hernia. Initial ultrasound showed no stomach at its normal position and the chest X-ray presented intrathoracic gas bubble nasogastric tube inside. An upper gastrointestinal contrast study confirmed complete herniation into thorax. Via exploratory laparotomy it carefully reintroduced abdomen, following reconstruction. A Thal fundoplication gastrostomy...
Restricted accessAbstractFirst published online September 29, 2014AbstractsVolume 9, Issue 3_supplhttps://doi.org/10.1111/ijs.12366
Introduction: Post-Transplant Lymphoproliferative disease is a serious complication of solid organ transplanted patients. We described patient who developed fulminant post-transplant lymphoproliferative (PTLD) as multivisceral transplant (MVT). Methods: Clinical, therapeutic and evolutionary analysis with MVT PTLD. Results: A 13-year-old male received second conventional due to loss the previous graft from exfoliative rejection described. He had history (1st graft) in 2018 short bowel...
Introduction: Tricohepatoenteric syndrome (THES) is a complex condition that confers poor life prognosis. We describe conventional multivisceral transplant (MVT) in patient with THES type II (THES II), who developed multiple infectious complications and graft versus host disease (GVHD). Methods: Clinical, therapeutic outcome of MVT are analyzed. Results: A 7-year-old male received first due to the development intestinal failure associated liver related described. He had also severe colitis...
Considering recent clinical and experimental evidence, expectations for using DCD-derived intestines have increased considerably. However, more knowledge about DCD procedure long-term results after intestinal transplantation (ITx) is needed. We aimed to describe in detail a ITx normothermic regional perfusion (NRP) preclinical model. Small bowel was obtained from pigs donors 1 h of NRP transplanted the recipients. Graft Intestinal samples were during transplantation. Ischemia-reperfusion...
We describe the unusual case of a female patient with history two mature teratomas non-correlated in terms location and occurrence. A 12-year-old girl presented at our consultation as result growing tumor hypogastric region, no further clinical signs. She had undergone surgery neonatally due to cystic sacrococcygeal teratoma, which was fully removed. No sequelae were noted additional treatment required over 10-year follow-up. Radiological examination showed large 20 × 12 18 cm mass extending...
Introduction: The aim was to update our experience with Sirolimus (SRL) in intestinal transplanted (IT) pediatric patients. Patients and methods: Between 1999 2018, 107 TI 83 patients were performed at a median age of 38 months transplant (range 6 m- 30 yo); 18 retransplanted, them twice. Initial manteinance treatment protocol Tacrolimus (TAC). Those who partially or completely converted SRL retrospectively reviewed. Results: Since 2008, used 31 patients, after 17 since 1 years). main...