A5026787998- Clinical Nutrition and Gastroenterology
- Organ Transplantation Techniques and Outcomes
- Organ and Tissue Transplantation Research
- Congenital Anomalies and Fetal Surgery
- Hematopoietic Stem Cell Transplantation
- Biomedical Ethics and Regulation
- Intestinal Malrotation and Obstruction Disorders
- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Genetic Syndromes and Imprinting
- Genetic and Kidney Cyst Diseases
- Diagnosis and treatment of tuberculosis
- Tumors and Oncological Cases
- Fungal Infections and Studies
- Pharmaceutical studies and practices
- Mycobacterium research and diagnosis
- Pancreatic function and diabetes
- Organ Donation and Transplantation
- Liver Disease and Transplantation
- Antifungal resistance and susceptibility
- Stoma care and complications
- Nail Diseases and Treatments
- Neurogenetic and Muscular Disorders Research
- Digestive system and related health
Hospital Universitario La Paz
2019-2024
Hospital La Paz Institute for Health Research
2021-2023
The current shortage of pediatric multivisceral donors accounts for the long time and mortality on waiting list patients. use after cardiac death, especially outbreak normothermic regional perfusion, has increased in recent years all solid organs except intestine, mainly because its higher susceptibility to ischemia-reperfusion injury. We present first literature case death transplantation a 13-month-old recipient from 2.5-month-old donor. Once exitus was certified, an extracorporeal...
Objective: We aimed to assess whether native spleen preservation during visceral transplantation (VT) affects graft-versus-host-disease (GVHD) incidence. Summary Background Data: GVHD is one of the most severe and frequently lethal hematological complications after VT procedures. Because there no specific treatment for GVHD, it imperative develop a strategy reduce donor lymphocyte engraftment proliferation. Methods: Our study included both clinical experimental data. A total 108 patients...
Aim/Background: High levels of immunosuppression required for intestinal transplant patients makes us alert potentially serious infections. We present 2 who developed tuberculosis (TB) infection along the follow-up. Case reports: Patient 1: This is a 30-year-old male presented volvulus at 16 yo and became anenteric. Few months later, he was succesfully transplanted with an isolated graft. He converted to Sirolimus (SRL) due renal insufficiency hypertension one year after transplant. Twelve...
Introduction: The aim was to update our experience with Sirolimus (SRL) in intestinal transplanted (IT) pediatric patients. Patients and methods: Between 1999 2018, 107 TI 83 patients were performed at a median age of 38 months transplant (range 6 m- 30 yo); 18 retransplanted, them twice. Initial manteinance treatment protocol Tacrolimus (TAC). Those who partially or completely converted SRL retrospectively reviewed. Results: Since 2008, used 31 patients, after 17 since 1 years). main...
Introduction: DCD has not been considered as a valid alternative for intestinal transplantation (IT). However, the use of normothermia recently improved results classic cold perfusion in other organs under this condition. Our aim was double: to test viability and function grafts using normothermic regional (NRP) an experimental model assess ischemic-reperfusion injury (IRI) small bowel human DCD. Methods: We used porcine with 8 donor-recipient pairs (25.5 ± 2.5 kg). Donors were supported NRP...
Introduction: The universal shortage of organs has prompted the growing use donations after circulatory death (DCDs). Kidneys, liver, lungs, pancreas, and, more recently, heart from DCDs have been successfully employed for transplantation in many centers worldwide. Nonetheless, DCD as a source intestinal grafts denied due to concerns regarding their ischemic susceptibility. This belief, fact, widely accepted by scientific community years. Now this myth is over: we present first three cases...
Purpose: Many different pre-conditioning immunosuppression protocols have been reported to improve outcomes of patient and graft survival in intestinal transplantation(IT). The use Alemtuzumab as an immunosuppressant inducer is not well studied pediatric IT. Our aim analyze its impact on immunological complications among this population, comparing used our center. M&M: A retrospective study immunosuppresion pediatric(<18yrs) IT was conducted. 103 (55multivisceral, 25intestinal,...
Introduction: To include the colon as part of an intestinal or multivisceral graft is still a matter debate. While some groups consider that it might be important for water absorption and residue breakdown without posing risks to patients, others state its inclusion could result in increase infectious complications. Our aim was analyze if presence grafted our patients has meant differences their outcome. Methods: Retrospective review historical series transplants comparing received those...
Purpose: Intestinal retransplantation is required in more than 10% of long term survivors, especially those who underwent isolated intestinal transplantation. However, no clear guidelines are available regarding indications, type graft and immunological management. Our aim to report our experience after children. Material methods: A retrospective study pediatric performed center the last 15 years (2003–2018) was conducted. Epidemiological anthropometric data, number grafts received by each...
Introduction: Recent improvements in intestinal rehabilitation programs allowed avoiding transplantation many cases. Conversely, improved outcomes prompt the use of for complex pathologies not included classical list indications. Our aim was to analyze our experience some these unusual indications and review their outcome when compared usual Methods: Retrospective historical series multivisceral transplants (1999–2018) identifying those cases which initial diagnosis among classic (short gut...
Introduction: To include the colon as part of an intestinal or multivisceral graft is still a matter debate. While some groups consider that it might be important for water absorption and residue breakdown without posing risks to patients, others state its inclusion could result in increase infectious complications. Our aim was analyze if presence grafted our patients has meant differences their outcome. Methods: Retrospective review historical series transplants comparing received those...
Introduction: The complications of intestinal failure (IF) in the childhood are serious and potentially fatal. We study evolution achievements an established Intestinal Rehabilitation Unit. Patients Methods: retrospectively reviewed all patients referred to our Unit from 1997 2020; we analyzed demographic clinical data, diagnostic therapeutic strategies implemented long-term evolution. look for prognostic factors depending on time program, age at first assessment, etiology associated...
Aim: Rapamycin (RAP) has recently demonstrated clear long-term benefits in visceral transplantation (VT). However, its use is limited to patients suffering FK side effects and there are no guidelines supporting the timing for a safe effective switch. Our aim was review our clinical experimental experience of RAP after VT. Materials Methods: series 107 VT reviewed. Only who survived more than 3 months were included (n=82). They divided three groups according maintenance immunosuppressive...
Introduction: Donor specific anti-HLA antibodies (DSA) impact negatively on the outcome of intestinal graft. Although use desensitization therapies is becoming more frequent in last years, issues as “when and how” still remain under discussion. The objective this study was to evaluate effectiveness DSA a pediatric transplant cohort. Methods: We studied retrospectively cohort 112 transplants. 14 procedures 11 transplants were carried out (figure 1A). Desensitization performed with different...
Introduction: VAC therapy consists of a non-invasive and dynamic system negative pressure that promotes healing, facilitating angiogenesis, eliminating the excess fluids. Its increased use in complex wounds is well described adult patients; however, its children with intestinal failure has been poorly documented. Malnutrition recurrent surgeries are common features patients admitted to Intestinal Rehabilitation Unit (IRU), which involves dealing weakened abdominal wall, whose healing...
Introduction: Choosing the most appropriate type of graft is often complex or depends on existence technical difficulties to perform one them. Our aim present some these cases in which controversy consisted deciding between liver (LT) and multivisceral transplantation (MVT). Methods: A retrospective review our historical series waiting list intestinal (IT) was carried out. Only patients who were considered discussed for LT vs MVT included. We out a descriptive evaluate prognosis according...