A5060217007- Herpesvirus Infections and Treatments
- Nerve injury and regeneration
- Spinal Cord Injury Research
- Cytomegalovirus and herpesvirus research
- Vector-Borne Animal Diseases
- Reproductive System and Pregnancy
- Toxoplasma gondii Research Studies
- Animal Disease Management and Epidemiology
- Cardiovascular Function and Risk Factors
- Virus-based gene therapy research
- Immune Response and Inflammation
- Digestive system and related health
- Neurogenesis and neuroplasticity mechanisms
- Veterinary Oncology Research
- Marine animal studies overview
- Diet, Metabolism, and Disease
- Cancer, Hypoxia, and Metabolism
- Mesenchymal stem cell research
- Skin and Cellular Biology Research
- Pregnancy and preeclampsia studies
- Mitochondrial Function and Pathology
- T-cell and Retrovirus Studies
- Gut microbiota and health
- Infectious Diseases and Mycology
- Mycotoxins in Agriculture and Food
Universidad Nacional de La Plata
2014-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2014-2024
Centro Científico Tecnológico - La Plata
2013-2021
Centro Científico Tecnológico - San Juan
2009-2020
Centro Científico Tecnológico - Tucumán
2016
Comisión de Investigaciones Científicas
2015
National University of Mar del Plata
2009
Key points Spontaneous sarcoplasmic reticulum (SR) Ca 2+ release events increased in fructose‐rich diet mouse (FRD) myocytes vs . control (CD) mice, the absence of significant changes SR load. In HEK293 cells, hyperglycaemia significantly enhanced [ 3 H]ryanodine binding and /calmodulin‐dependent protein kinase II (CaMKII) phosphorylation RyR2‐S2814 residue normoglycaemia. These increases were prevented by CaMKII inhibition. FRD augmented cardiac apoptosis WT CD‐WT which was co‐treatment...
N(omega)-nitro-L-arginine methyl ester (L-NAME) decreases the vasodilator effect of nitric oxide (NO) and induces pre-eclampsia in mouse. Sildenafil inhibits degradation increases vasodilation. This study aimed to determine effects sildenafil citrate on angiogenesis oxidative stress at maternal foetal interface pre-eclampsia-like mouse model induced by L-NAME. Twenty pregnant mice were divided into four groups: (i) vehicle control; (ii) L-NAME; (iii) sildenafil; (4) L-NAME+sildenafil. L-NAME...
Galectins play key roles in the inflammatory cascade. In this study, we aimed to analyze effect of galectin-1 (Gal-1) function intestinal epithelial cells (IECs) isolated from healthy and inflamed mucosa. IECs mice or patients with bowel diseases (IBD) were incubated different pro-inflammatory cytokines, Gal-1 binding, secretion homeostatic factors viability assessed. Experimental models food allergy colitis used evaluate vivo influence inflammation on binding modulation IECs. We found an...
The intestinal epithelium has a critical roll in host defence. One specialised cell type involved this function is the Paneth cell, which secretes many substances with antimicrobial properties response to different stimuli. Under pathological conditions, changes number, morphology and location as well granule composition have been reported. In normal animal, 1,25-dihydroxyvitamin D3 participates maintenance of mineral homeostasis, immunomodulation proliferation differentiation. Solanum...
Mice are commonly used as an experimental model to investigate the Equid herpesvirus 1 (EHV-1) infection. This easily reproduces disease, and clinical signs more or less similar those observed in horse, natural host. During infection, acute course of respiratory infection is mandatory for development adaptive immune response. Since interactions between EHV-1 anesthetics possible, study investigated whether early events murine pulmonary response could be affected by different anesthetics....
Background Intestinal transplantation (ITx) faces many challenges due to the complexity of surgery and multiple immunological reactions that lead necessity rigorous follow-up for early detection acute cellular rejection (ACR). Our aim was determine kinetics ACR using an experimental ITx model, with emphasis in characterization process different approaches, including use functional assays absorptive barrier function. Methods rats conducting serial sampling performed. Clinical monitoring,...
ABSTRACT: Equine herpesvirus type 1 (EHV-1) is an important pathogen that causes abortion, neonatal disease, respiratory disorders, and neurological syndrome in equine populations worldwide. To evaluate EHV-1 as a cause of abortion perinatal mortality Brazil, tissue samples from 105 aborted fetuses, stillbirths, foals up to one month age were examined using virus isolation, immunohistochemistry (IHC), histopathology, nested polymerase chain reaction (PCR). Two fetuses positive for by PCR,...
Abstract The ascending colon of most rodent species shows a longitudinal colonic groove that works as retrograde transport pathway for mixture bacteria and mucus toward the cecum. We describe morphology glycosylation pattern Lagostomus maximus to analyze role mucins in this anatomical feature. also studied distribution interstitial cells Cajal (ICC) evaluate their regulatory influence on gut motility. originated near cecocolic junction extended along mesenteric side colon, limited at both...
ABSTRACT The aim of this study was to determine the presence, number, and morphometrical characteristics Paneth cells (PC) in small intestine guinea pigs during lactation. We used 48 pups from 0 15 days old. Samples were fixed 10% buffered formaldehyde (pH 7.4) processed for histological studies using hematoxylin eosin (HE), Phloxine tartrazine or Masson's Trichome staining, immunohistochemistry lysozyme. PC morphologically identified at day 2 stainings, 4 HE, whereas they recognized birth....
Abstract Development of alternative therapies for treating functional deficits after different neurological damages is a challenge in neuroscience. Insulin‐like growth factor‐1 (IGF‐1) potent neurotrophic factor exerting neuroprotective actions brain and spinal cord. It used to prevent or treat injuries the central nervous system using administration routes animal models. In this study, we evaluated whether intracisternal (IC) route IGF‐1 gene therapy may abrogate at least reduce structural...
Solanum bonariense intoxication is characterized by cerebellar neuronal vacuolation, degeneration, and necrosis. Cerebellar Purkinje cells seem especially susceptible, but more research needed to determine the pathogenesis of necrosis mechanism cell susceptibility. Calbindin D28k (CbD28k) highly expressed in has been used as a marker for normal degenerative cells. The goal this study was describe S bonariense–induced disease ascertaining cell–specific changes using CbD28k expression...