A5042636684- Virus-based gene therapy research
- Amphibian and Reptile Biology
- Virology and Viral Diseases
- Veterinary Oncology Research
- Neurological diseases and metabolism
- Mycotoxins in Agriculture and Food
- Adipose Tissue and Metabolism
- Plant Toxicity and Pharmacological Properties
- SARS-CoV-2 and COVID-19 Research
- Herpesvirus Infections and Treatments
- Rabies epidemiology and control
- Sarcoma Diagnosis and Treatment
- Reproductive Physiology in Livestock
- Turtle Biology and Conservation
- Effects of Environmental Stressors on Livestock
- Barrier Structure and Function Studies
- Mitochondrial Function and Pathology
- Dermatological diseases and infestations
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Research and Treatments
- Genetic and phenotypic traits in livestock
- Skin and Cellular Biology Research
- Plant and fungal interactions
- Animal Behavior and Reproduction
- Infectious Diseases and Mycology
Universidad de la República de Uruguay
2015-2024
Universidad de Montevideo
2013-2024
Centro Uruguayo de Imagenología Molecular
2019
Universidade de Santiago de Compostela
2011-2017
Universidad La República
1997-2017
Universidade Federal de Santa Maria
2016
Universidade de Brasília
2016
Instituto de Investigaciones Biológicas Clemente Estable
1994-2015
Universitat Autònoma de Barcelona
2015
Universidad Nacional de La Plata
2015
Abstract The objective of this study was to test the effectiveness ivermectin for treatment mouse hepatitis virus (MHV), a type 2 family RNA coronavirus similar SARS-CoV-2. Female BALB/cJ mice were infected with 6,000 PFU MHV-A59 (group infected, n = 20) or and then immediately treated single dose 500 µg/kg + IVM, not PBS (control group, 16). Five days after infection/treatment, euthanized tissues sampled assess their general health status infection levels. Overall, results demonstrated that...
The protein Deleted in Breast Cancer 1 (Dbc1) is an important regulator of various transcription factors and epigenetic modulators, significantly influencing metabolism, obesity, aging-related processes. Knockout mice lacking Dbc1 exhibit severe obesity but remain protected from liver steatosis, insulin resistance, atherosclerosis. We hypothesized that this phenotype “healthy obesity” results adipose tissue expansion, which prevents free fatty acid spillover subsequent metabolic damage to...
The main findings of this study are that we determined there Trypanosoma cruzi strains adapted to transplacental transmission and completely different from the commonly used laboratory reference strains. This implies a specific strategy for vertical Chagas disease.
We examined the cerebellum and cerebrum of 4 vaccinated dogs, 3–60-mo-old, that displayed clinical signs canine distemper virus (CDV) infection, died 7–40 d after developing neurologic signs. The main histologic lesions were demyelination, gliosis, meningitis, perivascular lymphocytic cuffing, inclusion bodies. These similar in all cases regardless time since vaccination, except meningoencephalitis gliosis subacute 3 dogs chronic 1 dog. However, these differences did not appear to be related...
Cattle in western Uruguay that were eating Solanum bonariense developed periodic episodes of ataxia, hypermetria, hyperesthesia, head and thoracic limb extension, opisthotonus, nystagmus, falling to the side or backward. Similar clinical signs experimentally reproduced cattle by administration S. via rumen cannula at a dose 1,024 g/kg body mass. No significant gross lesions observed field cases induced cases. Spontaneous histologic similar included vacuolation, degeneration, loss Purkinje...
Amphibian parasites of the Order Dermocystida (Ichthyosporea) are widespread pathogens known mainly from Europe and North America, which cause primarily a disease skin subcutaneous tissue in their hosts. The taxonomy these organisms has been problematic given conserved morphology, similar clinical pathology. Currently recognized taxa belong to three closely related genera, Amphibiocystidium, Amphibiothecum, Rhinosporidium, whereas species Dermocystidium Sphaerothecum destruens include fish...
This work describes macroscopic and microscopic findings of pleural mesothelioma in a 6-y.o., , male German shepherd dog with dyspnea weight loss for 20 days. The animal was admitted to the Veterinary Hospital Facultad de Veterinaria Udelar, collapsed died during consultation. body referred Pathology Unit post-mortem examination. necropsy revealed hemoperitoneum, hepatomegaly, abundant hemothorax, large irregular mass mediastinum extending throughout cavity, adhered parietal pleura rib cage;...
Abstract Inflammation is an important process for epithelial barrier protection but when uncontrolled, it can also lead to tissue damage. The nuclear factor-kappa light chain enhancer of activated B cells (NF-κB) signaling pathway particularly relevant in the intestine, as seems play a dual role. Whereas NF-κB protects intestinal epithelium against various noxious stimuli, same mediates inflammatory diseases by inducing pro-inflammatory gene expression. availability appropriate vitro models...
Enterotoxemia caused by Clostridium perfringens type D is an important disease of sheep and goats with a worldwide distribution. Cerebral microangiopathy considered pathognomonic for ovine enterotoxemia seen in most cases the disorder sheep. However, these lesions are poorly described goats. In this article, we describe vasculocentric brain 44 caprine spontaneous C. enterotoxemia. Only 1 goat had gross changes brain, which consisted mild cerebellar coning. 8 (18%) showed microscopic lesions,...
Rabies has been an enigmatic disease because microscopic findings in central nervous system tissues do not always correlate well with the severity of clinical illness. Immunohistochemical staining calcium-binding protein calbindin (specifically CbD28k) seems to be technique most used identify Purkinje neurons under normal and pathological conditions. In present work, we evaluated CbD28k immunoreactivity cerebellar cortex natural virus (RABV)-infected cattle. We examined brains from 3 cows 6...
Abstract SARS-CoV2 is a single strand RNA virus member of the type 2 coronavirus family, responsible for causing COVID-19 disease in humans. The objective this study was to test ivermectin drug murine model infection using family similar SARS-CoV2, mouse hepatitis (MHV). BALB/cJ female mice were infected with 6,000 PFU MHV-A59 (Group Infected; n=20) and immediately treated one dose 500 μg/kg Infected + IVM; n=20), or not PBS (Control group; n=16). Five days after infection/treatment,...
Solanum bonariense intoxication is characterized by cerebellar neuronal vacuolation, degeneration, and necrosis. Cerebellar Purkinje cells seem especially susceptible, but more research needed to determine the pathogenesis of necrosis mechanism cell susceptibility. Calbindin D28k (CbD28k) highly expressed in has been used as a marker for normal degenerative cells. The goal this study was describe S bonariense–induced disease ascertaining cell–specific changes using CbD28k expression...
Histology is often underappreciated for the detection of amphibian pathogenic fungus Batrachochytrium dendrobatidis, cause potentially lethal skin disease chytridiomycosis. We evaluated sensitivity histology to detect chytrids in 20 wild specimens 2 frog species from Uruguay that were clinically normal, but confirmed by PCR be infected B. dendrobatidis. detected maturing and sporulated sporangia 15 (75%) frogs, which more sensitive than previously reported histology. The effort needed...
Intoxication with Solanum bonariense in cattle causes cerebellar cortical degeneration perikaryal vacuolation, axonal swelling, and death primarily of Purkinje cells, accumulation electron-dense residual storage bodies membrane-bound vesicles. The pathogenesis this disease is not fully understood. Previously, we proposed that inhibition protein synthesis cells among other altered metabolic pathways could lead to cytoskeletal alterations, subsequently altering cell-specific transport. In the...
Abstract The protein Deleted in Breast Cancer 1 (DBC1), a regulator of several transcription factors and epigenetic modulators, plays determinant roles metabolism regulation, obesity aging-related processes. Knockout mice for Dbc1, develop morbid but are protected against liver steatosis, insulin resistance atherosclerosis. We have proposed that this healthy phenotype was mainly due to the expansion adipose tissue, avoiding free-fatty acid spillover metabolic damage peripheral tissues. To...