Abstract We report the structure–activity relationship in antimicrobial activity of linear and branched poly(ethylene imine)s (L‐ B‐PEIs) with a range molecular weights (MWs) (500–12 000). Both L‐ B‐PEIs displayed enhanced against Staphylococcus aureus over Escherichia coli . B‐ L‐PEIs did not cause any significant permeabilization E. cytoplasmic membrane. induced depolarization S. membrane although not. The low MW caused little or no hemolysis while are hemolytic. less cytotoxic to human...

MR arthrography of the adult acetabular capsular-labral complex: correlation with surgery and anatomy.C Czerny, S Hofmann, M Urban, C Tschauner, A Neuhold, Pretterklieber, P Recht J KramerAudio Available | Share

PURPOSE: Intersphincteric resection of low rectal tumors is a surgical technique extending into the intersphincteric space. This procedure performed by synchronous abdominoperineal approach with mesorectal excision and entire or part internal sphincter. study was designed to evaluate long-term results this method focused on continence function oncologic results. METHODS: From 1984 2000, total 121 patients were operated on. The evaluated prospectively according detailed preoperative...

Heterologous expression in yeast cells revealed that NtAQP1, a member of the so-called PIP1 aquaporin subfamily, did not display increased water transport activity comparison with controls. Instead, an CO2-triggered intracellular acidification was observed. NtPIP2;1, which belongs to PIP2 subfamily plant aquaporins, behaved as true but lacked CO2-related function. Results from split YFP experiments, protein chromatography, and gel electrophoresis indicated proteins form heterotetramers when...

Surgery induces a variety of metabolic, endocrine, and immune changes collectively known as the "stress response," which may often lead to prolonged postoperative convalescence. Anesthetic management modulate this physiological response, thus affecting course. We hypothesized that intraoperative administration dexmedetomidine (DEX), sympatholytic agent, would reduce stress response improve quality recovery in patients undergoing major surgery.We conducted prospective randomized...

Perioperative myocardial ischemia (MI) is associated with postoperative cardiac morbidity. Postoperative sympatholysis may reduce the incidence of MI. This study evaluated such a reduction postoperatively administration prophylactic β-blockers in patients undergoing elective total knee arthroplasty epidural anesthesia and analgesia. One hundred seven were preoperatively randomized into two groups, control β-blockers, who received esmolol infusions on day surgery metoprolol for next 48 h to...

Controlled study to assess the efficacy of aprotinin and Amicar in reducing blood loss during complex spinal fusions.To compare clotting profile with a thromboelastogram patients deformities undergoing sequential anterior posterior fusions treated intraoperatively either or Amicar.Spinal fusion for correction adult is associated large losses despite implementation multiple factors reduce this loss. The antifibrinolytics have both been shown other surgical procedures potential Hence, we...

Management of acute postoperative pain is challenging, particularly in patients with preexisting narcotic dependency. Ketamine has been used at subanesthetic doses as a N-methyl D-aspartate (NMDA) receptor antagonist to block the processing nociceptive input chronic syndromes. This prospective randomized study was designed assess use ketamine an adjunct management tolerant after spinal fusions. Twenty-six for 1-2 level posterior lumbar fusions segmental instrumentation were randomly assigned...

Cationic amphiphilic polymethacrylate derivatives (PMAs) have shown potential as a novel class of synthetic antimicrobials. A panel PMAs with varied ratios hydrophobic and cationic side chains were synthesized tested for antimicrobial activity mechanism action. The are to be active against pathogenic bacteria, including drug-resistant Staphylococcus aureus, compared the natural peptide magainin which did not display any same strain. selected 47–63% methyl groups in showed minimum inhibitory...

<h3>Background:</h3> Interleukin 6 (IL-6), a marker of inflammation, is one the major cytokines released during joint replacement. In orthopedic patient population, high levels have been linked to many adverse effects including acute respiratory distress syndrome, postoperative mental status changes, and fever. We looked assess efficacy low-dose steroids on postinflammatory response as measured by IL-6 in patients undergoing bilateral total knee replacement (BTKR). The role has never...

Background: The perioperative inflammatory response as measured by elevated levels of interleukin-6 (IL-6) has been linked to acute respiratory distress syndrome, postoperative confusion, and fever. Because the extent surgery, patients undergoing bilateral total knee arthroplasty may be at high risk complications. We had found a significant decrease in IL-6 having replacement who received two doses 100 mg hydrocortisone eight hours apart; however, twenty-four hours, were equal those group...

Background Prospective trials of enhanced recovery after spine surgery are lacking. We tested the hypothesis that an pathway improves quality one- to two-level lumbar fusion. Methods A patient- and assessor-blinded trial 56 patients randomized (17 evidence-based pre-, intra-, postoperative care elements) or usual was performed. The primary outcome Quality Recovery-40 score (40 200 points) at day 3. Twelve points defined clinically important difference. Secondary outcomes included days 0 2,...

The properties of dilute neutron matter are mostly determined by the s-wave two-body (2N) interaction, while three-body (3N) interactions suppressed Pauli principle. In a previous work, we showed that it can be advantageous to use renormalization group based effective with cutoffs scaled Fermi momentum, especially at low densities. case, induced 3N may become important. this compute interaction similarity flow 2N interaction. We work in momentum-space hyperspherical partial wave basis and...

Many common Skyrme functionals present ferromagnetic instabilities or unrealistic density dependence of the spin-1 Landau parameters. To solve these problems, we consider interaction as a density-functional rather than density-dependent two-body force. This allows us to adjust spin-dependent terms new extended our previous paper [M. Duan and M. Urban, Phys. Rev. C 110, 065806 (2024)] independently without altering properties spin saturated matter. The parameters are determined by fitting...

Sudden profound hypotensive and/or bradycardic events (HBE) have been reported in >20% of patients undergoing shoulder arthroscopy the sitting position under interscalene block anesthesia.Retrospective studies suggest that administration beta-blockers is safe and may decrease incidence these episodes. We performed a randomized, prospective study to evaluate prophylaxis events. One hundred fifty were randomized one three groups (placebo; prophylactic metoprolol achieve heart rate <60 bpm or...

Abstract Background Infection plays a role in the pathogenesis of many human malignancies. Whether prostate cancer (PCa) - an important health issue aging male population Western world belongs to these conditions has been matter research since 1970 s. Persistent serum antibodies are proof present or past infection. The aim this study was compare against genitourinary infectious agents between PCa patients and controls with benign hyperplasia (BPH). We hypothesized that elevated antibody...

Early childhood caries (ECC) is closely related to high numbers of mutans streptococci, lactobacilli and &lt;i&gt;Candida albicans&lt;/i&gt;. Oral colonization these microorganisms was monitored in a prospective clinical study order investigate the effect comprehensive treatment under general anesthesia sustainability microbial changes. Saliva samples were collected from 50 healthy infants with ECC before regular intervals up 12 months after treatment. Microorganisms detected by cultivation...

The inner crust of neutron stars is supposed to be inhomogeneous and composed dense structures (clusters) that are immersed in a dilute gas unbound neutrons. Here we consider spherical clusters forming body-centered cubic (BCC) crystal cylindrical rods arranged hexagonal lattice. We study the relative motion these using superfluid hydrodynamics. Within this approach, which relies on assumption Cooper pairs small compared crystalline structures, find entrainment neutrons by very weak since...