A5102895594- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Global Cancer Incidence and Screening
- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Colorectal Cancer Screening and Detection
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Breast Cancer Treatment Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Genetic factors in colorectal cancer
- Advanced Breast Cancer Therapies
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Surgical Treatments
- CAR-T cell therapy research
- Cancer Risks and Factors
- HER2/EGFR in Cancer Research
- Brain Metastases and Treatment
- Cardiac Imaging and Diagnostics
- Gastric Cancer Management and Outcomes
- Cancer Research and Treatments
- Microfinance and Financial Inclusion
- FinTech, Crowdfunding, Digital Finance
- Nanoplatforms for cancer theranostics
- Lung Cancer Research Studies
Lyell McEwin Hospital
2015-2025
Assistance Publique – Hôpitaux de Paris
2024
Institut Català d'Oncologia
2024
Universitat Autònoma de Barcelona
2024
Hôpital Saint-Antoine
2024
Sorbonne Université
2024
Hôpital Foch
2024
Cancer Council SA
2022-2024
Indian Institute of Management Shillong
2022-2024
Aix-Marseille Université
2024
PURPOSE Phase III studies of intravenous amivantamab demonstrated efficacy across epidermal growth factor receptor ( EGFR )–mutated advanced non–small cell lung cancer (NSCLC). A subcutaneous formulation could improve tolerability and reduce administration time while maintaining efficacy. PATIENTS AND METHODS Patients with -mutated NSCLC who progressed after osimertinib platinum-based chemotherapy were randomly assigned 1:1 to receive or amivantamab, both combined lazertinib. Coprimary...
BackgroundPatients with microsatellite-instability–high (MSI-H) or mismatch-repair–deficient (dMMR) metastatic colorectal cancer have poor outcomes standard chemotherapy without targeted therapies. Nivolumab plus ipilimumab has shown clinical benefit in nonrandomized studies of MSI-H dMMR cancer.MethodsIn this phase 3 open-label trial, we randomly assigned patients unresectable and status according to local testing receive, a 2:2:1 ratio, nivolumab ipilimumab, alone, The dual primary end...
Importance Chronic breathlessness is common in people with chronic obstructive pulmonary disease (COPD). Regular, low-dose, extended-release morphine may relieve breathlessness, but evidence about its efficacy and dosing needed. Objective To determine the effect of different doses on worst COPD after 1 week treatment. Design, Setting, Participants Multicenter, double-blind, placebo-controlled randomized clinical trial including (defined as a modified Medical Research Council score 3 to 4)...
397600 Background: While PD-1 inhibitors demonstrated survival benefit compared to chemotherapy in patients (pts) with PD-L1-high, NSCLC, less than half of pts respond monotherapy. Novel therapeutics or combinations are necessary improve outcomes. Domvanalimab (D) is an Fc-silent humanized IgG1 monoclonal antibody (mAb) that blocks T cell Immunoglobulin and ITIM domain (TIGIT), thereby reducing immunosuppression T/NK cells promoting antitumor activity. Etrumadenant (E) a selective dual...
3503 Background: NIVO + IPI demonstrated superior progression-free survival (PFS) vs chemo in patients (pts) with previously untreated MSI-H/dMMR mCRC the randomized phase 3 CheckMate 8HW study (NCT04008030). We report expanded efficacy analysis from prespecified interim of 1L setting. Methods: Pts unresectable or and status by local testing were enrolled across different lines therapy 2:2:1 to (240 mg) (1 mg/kg) Q3W (4 doses, then 480 mg Q4W), Q2W (6 ± targeted therapies; treatments...
Inequalities in survival from colorectal cancer (CRC) across socioeconomic groups and by area of residence have been described various health care settings. Few population-wide datasets which include clinical treatment information are available Australia to investigate disparities. This study examines socio-demographic differences for CRC patients South (SA), using a database derived via linkage administrative surveillance datasets. The population comprised all cases diagnosed 2003-2008...
MRI provides a non‐invasive diagnostic platform to quantify the physical and physiological attributes of skeletal muscle at rest in response exercise. MR relaxation parameters ( T 1 , 2 *) are characteristic tissue composition metabolic properties. With recent advent quantitative techniques that allow rapid acquisition * maps, we posited an integrated treadmill exercise–quantitative relaxometry paradigm can rapidly characterize exercise‐induced changes parameters. Accordingly, investigated...
Background: Registry data from four major public hospitals indicate trends in clinical care and survival colorectal cancer over three decades, 1980 to 2010. Materials Methods: Kaplan-Meier productlimit estimates Cox proportional hazards models were used investigate disease-specific multiple logistic regression analyses explore first-round treatment trends. Results: Five-year survivals increased 48% for 1980-1986 63% 2005-2010 diagnoses. Survival increases applied each ACPS stage (Australian...
Objectives Some early studies indicated lower survival with longer time from diagnosis to cancer treatment, but others showed the reverse. We investigated treatment of colorectal and associations survival. Setting participants Clinical registry data for cases diagnosed in 2000–2010 at four major public hospitals South Australia treated by surgery (n=1675), radiotherapy (n=616) and/or systemic therapy (n=1556). Design A historic cohort design, rank-order tests ordinal clinical...
<h3>Introduction</h3> Chronic breathlessness is highly prevalent and distressing to patients families. No medication registered for its symptomatic reduction. The strongest evidence regular, low-dose, extended- release (ER) oral morphine. A recent large phase III study suggests the subgroup most likely benefit have chronic obstructive pulmonary disease (COPD) modified Medical Research Council scores of 3 or 4. This protocol an adequately powered, parallel-arm, placebo-controlled, multisite,...
8613 Background: MYTX-011 is a novel cMET-targeting vcMMAE ADC engineered for pH-dependent binding. This results in more efficient payload delivery, which drives efficacy tumors over wide range of cMET expression, including potentially >50% NSCLC patients (pts). Here we report safety and preliminary from dose escalation pts who received ≥4.0 mg/kg (mpk), the clinically active range, Phase 1 KisMET-01 study. Methods: (NCT05652868) multicenter, first-in-human study with previously treated,...
3115 Background: CDK2 inhibition could represent a novel treatment (tx) option for patients (pts) with resistance to CDK4/6 inhibitors (CDK4/6i) and/or increased cyclin E1 activity. BG-68501 is highly potent inhibitor high selectivity (~100x) vs other CDK family members. We present dose-escalation data of as monotherapy or in combination fulvestrant pts HR+/HER2- metastatic breast cancer (BC) and advanced solid tumors (NCT06257264). Methods: This the phase first-in-human, 1a/b, open-label,...
Adjuvant care for colorectal cancer (CRC) has increased over the past 3 decades in South Australia (SA) accordance with national treatment guidelines. This study explores (1) receipt of adjuvant therapy CRC SA as related to guideline recommendations, a focus on stage C colon and B rectal cancer; (2) timing these therapies relation surgery; (3) comparative survival outcomes.Data from Clinical Cancer Registry 4 tertiary referral hospitals 2000 2010 were examined. Patterns compared guidelines...
We report a case of 74-year-old man who developed myocarditis complicated by atrioventricular (AV) block following two doses nivolumab for the treatment non-small cell lung cancer. A diagnosis drug-induced acute with complete AV was considered on basis elevated troponin, new onset left ventricular (LV) systolic dysfunction, absence myocardial infarction and some findings suggestive cardiac magnetic resonance. The patient commenced glucocorticoids, perindopril carvedilol. LV dysfunction...
Abstract Background This analysis aims to evaluate health-related quality of life (HrQoL) (primary outcome for this analysis), nausea and vomiting, pain in patients with inoperable malignant bowel obstruction (IMBO) due cancer or its treatments randomised standardised therapies plus octreotide placebo over a maximum 72 h double-blind clinical trial. Methods Adults IMBO vomiting recruited through 12 services spanning inpatient, consultative community settings Australia were subcutaneous...
Rewards-based crowdfunding (RBC) has recently gained popularity as an alternative means of finance to help entrepreneurs bring novel projects life. We theorize that backers perceive implicit psychological contract with campaign creators. When promised rewards fail materialize post fundraising, may entrepreneurs’ failure deliver a violation their him or her. Drawing on theory and using Eisenhardt’s comparative case methodology, we generate insights about crowd reactions creators’ backers. Our...
Abstract BACKGROUND: Anti-PD-1 checkpoint inhibitor (CPI) monotherapy has demonstrated modest activity in pre-treated mTNBC, with single digit objective response rates (ORR) observed. Our prior data suggests that local electroporation after intratumoral administration of tavokinogene telseplasmid (IT-tavo-EP), a plasmid encoding the proinflammatory cytokine IL-12, can render CPI non-responsive mTNBC sensitive to therapy. The phase II KEYNOTE-890/OMS-I141 study was therefore designed evaluate...
Introduction: A comprehensive trimodality approach has become the standard of care for patients with locally advanced rectal cancer. However, sequencing and duration chemotherapy chemoradiotherapy around surgery varies between clinical studies geographical regions. Growing evidence is also mounting strategies such as total neoadjuvant therapy non-operative management carefully selected patients.Areas covered: We provide a perspective review current controversies in treatment cancer including...
Poor intra-tumoural vascularity contributes to a lack of response chemotherapy in pancreatic cancers. Preliminary data suggest that the addition endoscopic ultrasound (EUS)-guided injection phosphorus-32 (
In Brief A 77-year-old woman presented with gradually progressing right sciatica of 2 years duration. She was investigated a magnetic resonance imaging the lumbosacral spine which did not reveal any abnormality. Magnetic pelvis then performed and revealed inferior gluteal vein varicosities causing compression adjacent sciatic nerve resulting in sciatica. Pain relieved by walking likely due to collapse vein. This patient declined surgery but benefit has been reported similar cases. radiating...