A5076891531- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Atomic and Subatomic Physics Research
- Cardiac Valve Diseases and Treatments
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Viral Infections and Immunology Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Cardiovascular and exercise physiology
- Hemodynamic Monitoring and Therapy
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Disease and Adiposity
- Advanced Neuroimaging Techniques and Applications
- Non-Invasive Vital Sign Monitoring
- Peptidase Inhibition and Analysis
- Cardiac electrophysiology and arrhythmias
- Takotsubo Cardiomyopathy and Associated Phenomena
- Peripheral Artery Disease Management
- Cerebrovascular and Carotid Artery Diseases
- Neuropeptides and Animal Physiology
- Diabetes Treatment and Management
- Renin-Angiotensin System Studies
The Ohio State University
2013-2025
The Ohio State University Wexner Medical Center
2013-2023
Lung Institute
2016-2023
Boston Scientific (United States)
2023
Columbus Oncology and Hematology Associates
2020
Ohio University
2018
Southern Illinois University School of Medicine
2006
Background Contemporary advances in low-field magnetic resonance imaging systems can potentially widen access to cardiovascular (CMR) imaging. We present our initial experience building a comprehensive CMR protocol on commercial 0.55 T system with gradient performance of 26 mT/m amplitude and 45 T/m/s slew rate. To achieve sufficient image quality, we adapted standard techniques when possible, implemented compressed-sensing (CS) based needed an effort compensate for the inherently low...
MRI provides a non‐invasive diagnostic platform to quantify the physical and physiological attributes of skeletal muscle at rest in response exercise. MR relaxation parameters ( T 1 , 2 *) are characteristic tissue composition metabolic properties. With recent advent quantitative techniques that allow rapid acquisition * maps, we posited an integrated treadmill exercise–quantitative relaxometry paradigm can rapidly characterize exercise‐induced changes parameters. Accordingly, investigated...
Measurement of blood oxygen saturation (O2 saturation) is great importance for evaluation patients with many cardiovascular diseases, but currently there are no established non-invasive methods to measure O2 in the heart. While T2-based CMR oximetry have been previously described, these approaches rely on technique-specific calibration factors that may not generalize across patient populations and impractical obtain individual patients. We present a solution utilizes multiple T2 measurements...
A noncontrast, electrocardiographically triggered, navigator-gated, three-dimensional, balanced steady-state free precession MR angiography research sequence on a wide-bore 0.55-T system demonstrated reliable performance in qualitative and quantitative measures compared with 1.5 T.
CMR has not seen widespread adoption beyond large urban academic centers. The reasons for this limited uptake include the cost, time-intensive nature and special expertise of CMR. Self-navigated 5D, x-y-z-cardiac-respiratory, free-funning whole-heart using self-navigation (5D CMR) implemented on a low-field clinical scanner may help bridge gap bi-ventricular function assessment left atrium volume index measurement. Whole-heart 3D radial phyllotaxis bSSFP data were collected in 10 healthy...
Abstract Purpose To propose and validate a cardiac T 1 ρ mapping sequence at 0.55 comparing continuous‐wave adiabatic spin‐lock (SL) preparation pulses. Methods The proposed 2D acquires four single‐shot balanced SSFP readout images with differing contrasts in single breath‐hold. first three are prepared pulses different durations, while the last image uses saturation pulse immediately before data acquisition. map is calculated using 3‐parameter fitting method. Bloch equation simulations were...
While cardiac amyloidosis (CA) classically involves the left ventricle (LV), less is known about its impact on right (RV) and pulmonary vasculature. We performed a retrospective analysis to identify prevalence types of hypertension (PH) profiles in CA determine haemodynamic cardiovascular magnetic resonance (CMR) predictors major adverse events (MACE).Patients with who underwent CMR heart catheterisation (RHC) within 1 year between 2010 2019 were included. Patients assigned following based...
Abstract Purpose Differentiation of the cause left ventricular hypertrophy (LVH) is challenging in cases with co-existing hypertension. CMR offers assessment diffuse myocardial abnormalities via T1 mapping extracellular volume fraction (ECV) and macroscopic fibrosis late gadolinium enhancement imaging (LGE). The goal study was to understand if parameters can differentiate hypertensive cardiomyopathy (HC) from cardiac amyloidosis (CA) patients hypertension heart failure, using endomyocardial...
Purpose To evaluate the reproducibility and repeatability of high‐resolution, isotropic thoracic abdominal aortic wall measurements, determine implications they have on number subjects necessary for future clinical trials. Materials Methods Using a T1‐weighted three‐dimensional MRI SPACE sequence, we evaluated interobserver, intraobserver, scan–rescan variability measurements in 15 cardiovascular diseased patients 6 normal volunteers. Main outcome analyses were intracorrelation coefficient...
Maximal oxygen consumption (max) measured by cardiopulmonary exercise testing (CPX) is the gold standard for assessment of cardiorespiratory fitness. Likewise, cardiovascular magnetic resonance (CMR) quantification cardiac function. The combination CPX and CMR may offer unique insights into pathophysiology; however, MRI-compatible equipment needed to combine these tests has not been available date. We sought determine whether in MRI environment, using modified yields results equivalent those...
A low field strength (B0) system could increase cardiac MRI availability for patients otherwise contraindicated at higher field. Lower equipment costs also broaden MR accessibility. The current study investigated the feasibility of function with steady‐state free precession and flow assessment phase contrast (PC) cine images 0.35 T, evaluated differences in myocardial relaxation times using quantitative T1, T2 T2* maps by comparison 1.5 3 T results a small cohort six healthy volunteers....
The renin-angiotensin system is well recognized as a mediator of pathophysiological events in atherosclerosis. benefits renin inhibition atherosclerosis, especially when used combination with angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEIs/ARBs) are currently not known. We hypothesized that treatment the inhibitor aliskiren patients established cardiovascular disease will prevent progression atherosclerosis determined by high-resolution magnetic resonance...