A5037078676- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Hemoglobinopathies and Related Disorders
- Hepatitis C virus research
- Blood donation and transfusion practices
- Phosphodiesterase function and regulation
- Asthma and respiratory diseases
- Mast cells and histamine
- HIV-related health complications and treatments
Beijing YouAn Hospital
2023-2024
Capital Medical University
2023-2024
Sichuan University
2024
Phosphodiesterase 4 (PDE4) inhibitors are effective therapeutic agents for various inflammatory diseases. Roflumilast, apremilast, and crisaborole have been developed approved the treatment of chronic obstructive pulmonary disease psoriatic arthritis, atopic dermatitis. Inflammation underlies many vascular diseases, yet role PDE4 in these diseases remains inadequately explored. This review elucidates clinical applications anti-inflammatory mechanisms inhibitors, as well their potential...
<sec> <title>BACKGROUND</title> HIV-1 infection continues to affect global health. Although antiretrovirals can reduce the viral load or prevent infection, current drugs require daily oral use with a high adherence level. Long-acting (LA-ARVs) significantly improve medication and are essential for prophylaxis therapy. </sec> <title>OBJECTIVE</title> This study aimed investigate safety efficacy of long-acting cabotegravir (CAB-LA) rilpivirine (RPV-LA) in prevention treatment infection....