Abstract Background Conicity index, body-shape lipid accumulation product (LAP), waist circumference (WC), triglyceride, triglyceride-glucose (TyG) hepatic steatosis index (HSI), waist-to-height ratio (WHtR), TyG index-related parameters (TyG-WHtR, TyG-BMI, TyG-WC), body mass (BMI), visceral adiposity triglyceride to high-density lipoprotein cholesterol and roundness have been reported as reliable markers of non-alcoholic fatty liver disease (NAFLD). However, there is debate about which the...

Purpose: Diabetes is one of the most prevalent chronic diseases in world, and its prevalence expected to rise further. To help understand utility ratio non-high-density lipoprotein cholesterol high-density (NHHR) diabetes prevention, this large-scale longitudinal cohort study aims explore association NHHR with risk compare it as a predictor conventional lipid parameters. Patients Methods: This observational extracted data from NAGALA conducted Japan between 2004 2015. Multivariate Cox...

Abstract Background Atherosclerosis is closely linked with glucose metabolism. We aimed to investigate the role of atherogenic index plasma (AIP) in reversal prediabetes normal blood levels or its progression diabetes. Methods This multi-center retrospective cohort study included 15,421 prediabetic participants from 32 regions across 11 cities China, under aegis Rich Healthcare Group’s affiliated medical examination institutions. Throughout follow-up period, we monitored changes glycemic...

Abstract Background The alanine aminotransferase (ALT)/aspartate (AST) ratio has been considered an alternative marker for hepatic steatosis. However, few studies have investigated the association of ALT/AST with non-alcoholic fatty liver disease (NAFLD) in nonobese people. Methods A total 12,127 participants who were free NAFLD participated this study. divided into quintiles ratio. Multiple Cox regression models used to explore new-onset NAFLD. Results During five-year follow-up period,...

Conventional and unconventional lipid parameters are associated with diabetes risk, the comparative studies on for predicting future however, still extremely limited, value of conventional in has not been evaluated. This study was designed to determine predictive development diabetes.The a longitudinal follow-up 15,464 participants baseline normoglycemia. At baseline, such as low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), total (TC), high-density (HDL-C) were...

Body mass index (BMI) and lipid parameters are the most commonly used anthropometric biomarkers for assessing nonalcoholic fatty liver disease (NAFLD) risk. This study aimed to assess quantify mediating role of traditional non-traditional on association between BMI NAFLD.Using data from 14,251 subjects NAGALA (NAfld in Gifu Area, Longitudinal Analysis) study, mediation analyses were performed explore roles [total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C),...

Abstract Background It is known that measuring the triglyceride glucose (TyG) index and TyG-related parameters [triglyceride glucose-body mass (TyG-BMI), glucose-waist circumference (TyG-WC), to height ratio (TyG-WHtR)] can predict diabetes; this study aimed compare predictive value of baseline TyG for onset diabetes at different future periods. Methods We conducted a longitudinal cohort involving 15,464 Japanese people who had undergone health physical examinations. The subject’s were...

Remnant cholesterol (RC) is a highly atherogenic lipid. Previous studies have shown that RC was closely associated with many metabolism-related diseases. However, the relationship of metabolic syndrome (MetS) remains unclear. This study's objective to investigate MetS. A total 60,799 adults who received health assessments were included in this study. calculated by subtracting directly measured values for low-density lipoprotein (LDL-C) and high-density (HDL-C) from (TC) divided into 5 groups...

Objective The Estimated Glucose Disposal Rate (eGDR) serves as a surrogate marker for insulin resistance, with numerous studies highlighting its significant prognostic value. This paper aims to analyze the impact of eGDR on cardiovascular and all-cause mortality across different glycemic metabolic statuses, including normal fasting glucose (NFG), prediabetes, diabetes. Methods study included 46,016 American adults who underwent health examinations part National Health Nutrition Examination...

Abstract Background Low-density lipoprotein to high density (LDL/HDL) cholesterol ratio has been reported predict the risk of many metabolic diseases. However, association between LDL/HDL and nonalcoholic fatty liver disease (NAFLD) not established. Methods A longitudinal cohort design was adopted in this study; 9767 non-obese subjects without NAFLD were included analyzed. The grouped according quintile ratio. cumulative incidence independent effect on during 5 years follow-up calculated...

Triglyceride glucose-body mass index (TyG-BMI) has been recommended as an alternative indicator of insulin resistance. However, the association between TyG-BMI and pre-diabetes remains to be elucidated.More than 100,000 subjects with normal glucose at baseline received follow-up. The main outcome event concern was defined according diagnostic criteria by American Diabetes Association (ADA) in 2018 World Health Organization (WHO) 1999. A Cox proportional hazard regression model used evaluate...

Abstract Background Remnant cholesterol (RC) mediates the progression of coronary artery disease, diabetic complications, hypertension, and chronic kidney disease. Limited information is available on association RC with nonalcoholic fatty liver disease (NAFLD). This study aimed to explore whether can be used independently evaluate risk NAFLD in general population analyze predictive value for NAFLD. Methods The included 14,251 subjects enrolled a health screening program. was diagnosed by...

Remnant cholesterol (RC) is the of triglyceride-rich lipoproteins, which has a high degree atherogenic effect. To date, epidemiological evidence supports that higher RC levels lead to greater risk adverse cardiovascular events in patients with diabetes, but nature association between and diabetes remains unclear. This study was designed assess new-onset investigate whether there causal relationship two.The subjects included 15,464 individuals general population who participated health...

Triglyceride glucose body mass index (TyG-BMI) has been shown to be strongly associated with a variety of chronic diseases. However, little is known about the associations between TyG-BMI and normal-high blood pressure (BP) values hypertension (HTN).The current study was cross-sectional in design included 15,464 non-diabetic participants recruited 1994 2016 NAGALA (NAfld Gifu Area, Longitudinal Analysis) study. Associations BP HTN were assessed using multivariate logistic regression. The...

Abstract Background Obesity is the most important driver of non-alcoholic fatty liver disease (NAFLD); nevertheless, relationship weight-adjusted waist index (WWI), a new obesity index, with NAFLD unclear. Methods This retrospective study used data from NAGALA project 1994 to 2016. WWI values were calculated using circumference (WC) and weight measurements participants. Three stepwise adjusted logistic regression models developed assess in whole population both sexes. Additionally, we also...

Abstract Background Insulin resistance (IR) plays a crucial role in the occurrence and progression of diabetes. This study aimed to evaluate compare predictive value four IR surrogates, including triglycerides glucose (TyG) index, TyG body mass index (TyG-BMI), triglycerides/high-density lipoprotein cholesterol (TG/HDL-C) ratio, metabolic score for (MetS-IR) diabetes two large cohorts. Methods A total 116,661 adult participants from China Rich Healthcare Group 15,464 Japanese NAGALA cohort...

Abstract Background Prediabetes is a high-risk state for diabetes, and numerous studies have shown that the body mass index (BMI) triglyceride-glucose (TyG) play significant roles in risk prediction blood glucose metabolism. This study aims to evaluate relative importance of BMI combination with TyG (TyG-BMI) predicting recovery from prediabetic status normal levels. Methods A total 25,397 subjects recruited 32 regions across China. Normal fasting (NFG), prediabetes, diabetes were defined...

Abstract Natural products were extracted from traditional Chinese herbal emerging as potential therapeutic drugs for treating cardiovascular diseases. This study examines the role and underlying mechanism of dihydromyricetin (DMY), a natural compound Ampelopsis grossedentata , in atherosclerosis. DMY treatment significantly inhibits atherosclerotic lesion formation, proinflammatory gene expression influx lesional macrophages CD4‐positive T cells vessel wall hepatic inflammation, whereas...

Emerging evidence suggests that cardiometabolic index (CMI) is closely related to diabetes, hypertension, stroke, cardiovascular disease, and kidney which implies CMI has the value as an indicator of metabolic diseases. However, data on relationships between non-alcoholic fatty liver disease (NAFLD) risks have not been reported. This study designed examine association NAFLD in general population.The current included 14,251 subjects whose was product triglyceride/high-density lipoprotein...

Objective Visceral adipose tissue assessment holds significant importance in diabetes prevention. This study aimed to explore the association between newly proposed Metabolic Score for Fat (METS-VF) and risk further assess predictive power of baseline METS-VF occurrence different future periods. Methods longitudinal cohort included 15,464 subjects who underwent health screenings. The METS-VF, calculated using formula developed by Bello-Chavolla et al., served as a surrogate marker visceral...

Objective The metabolic score for insulin resistance (MetS-IR) is an emerging surrogate marker (IR). This study aimed to investigate the association and sex differences between MetS-IR prediabetes risk in a Chinese population. Methods cohort included 100,309 adults with normoglycemia at baseline had followed longitudinally 5 years, prediabetes, defined according 2018 American Diabetes Association (ADA) recommended diagnostic criteria, as outcome of interest. Multivariate Cox proportional...

Abstract Background Body mass index (BMI) and lipid disorders are both known to be strongly associated with the development of diabetes, however, indirect effect parameters in BMI-related diabetes risk is currently unknown. This study aimed investigate mediating role association BMI risk. Methods We assessed BMI, as well including high-density lipoprotein cholesterol(HDL-C), low-density cholesterol(LDL-C F LDL-C S ), triglycerides(TG), total cholesterol(TC), remnant cholesterol(RC),...

Abstract Aims The value of the systemic immune‐inflammatory index (SII) in assessing adverse outcomes various cardiovascular diseases has been extensively discussed. This study aims to evaluate predictive and risk stratification ability SII for 30 day mortality patients with acute decompensated heart failure (ADHF). Methods analysis included 1452 hospitalized ADHF, all participants being part China Jiangxi‐acute failure1 project. capability as well its correlation among ADHF patients, was...

Objective: To investigate the characteristics of hand dysfunction and its associated factors in patients with rheumatoid arthritis (RA). Methods: A cross-sectional study. Patients RA were recruited from January 2019 to April 2024 at Department Rheumatology Immunology, Sun Yat-Sen Memorial Hospital, University. Demographic clinical data collected, including age, gender, active smoking, disease duration, time morning stiffness, factor anti-cyclic citrullinated peptide antibody, activity,...

Objective Prediabetes is a chronic condition characterized by elevated blood glucose levels that are not yet high enough to be classified as diabetes. It particularly prevalent among middle-aged and elderly populations. This study aims investigate the association between novel marker of insulin resistance-the estimated disposal rate (eGDR)-and reversion prediabetes normoglycaemia or progression diabetes in Chinese population. Methods prospective cohort utilized baseline data from 2011 China...