A5101499081- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Musculoskeletal synovial abnormalities and treatments
- Liver Disease Diagnosis and Treatment
- Gout, Hyperuricemia, Uric Acid
- Systemic Lupus Erythematosus Research
- Lymphoma Diagnosis and Treatment
- Spondyloarthritis Studies and Treatments
- Circular RNAs in diseases
- Inflammasome and immune disorders
- Cardiac Ischemia and Reperfusion
- Chronic Lymphocytic Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Medicinal Plants and Bioactive Compounds
- IL-33, ST2, and ILC Pathways
- Microbial metabolism and enzyme function
- Case Reports on Hematomas
- Mesenchymal stem cell research
- Peroxisome Proliferator-Activated Receptors
- Cancer, Hypoxia, and Metabolism
- High Temperature Alloys and Creep
- Head and Neck Cancer Studies
- Heat shock proteins research
- Quinazolinone synthesis and applications
- Fatigue and fracture mechanics
Sun Yat-sen Memorial Hospital
2020-2025
Sun Yat-sen University
2020-2025
Fudan University
2019-2024
Second Affiliated Hospital of Nanchang University
2017-2022
Nanchang University
2017-2022
Peking University
2019
Jiangnan University
2019
Hubei Academy of Agricultural Sciences
2019
Iwate University
2019
Sichuan University
2019
Synovium fibroblast-like synoviocytes (FLSs) are important participants in the pathogenesis of synovitis and joint destruction rheumatoid arthritis (RA). Pyroptosis is a pro-inflammatory cell lytic programmed death mechanism mediated by gasdermin (GSDM) family proteins. In this study, we demonstrated increased expression GSDME levels GSDME-mediated pyroptosis RA synovial tissues. vitro, stimulation with TNF-α plus hypoxia mimicking inflammatory hypoxic environment synovium induced RA-FLSs...
Objective: To investigate the characteristics of hand dysfunction and its associated factors in patients with rheumatoid arthritis (RA). Methods: A cross-sectional study. Patients RA were recruited from January 2019 to April 2024 at Department Rheumatology Immunology, Sun Yat-Sen Memorial Hospital, University. Demographic clinical data collected, including age, gender, active smoking, disease duration, time morning stiffness, factor anti-cyclic citrullinated peptide antibody, activity,...
To investigate the epidemiology of hepatitis B virus (HBV) infection in patients with rheumatoid arthritis (RA) China and its association RA disease characteristics.
Muscle mass loss is common in long-standing rheumatoid arthritis (RA). The aim was to explore the prevalence and effects of RA disease characteristics patients with early RA.
Associations between rheumatoid arthritis (RA) and reduced skeletal muscle have been studied, we firstly reported myopenia independently predict one-year radiographic progression in RA. Myokine myostatin can negatively regulate mass promote osteoclast differentiation. However, there is no report about their relationships RA patients. We explored the relationship of serum disease characteristics, as well aggravated joint destruction during follow-up. Consecutive patients were recruited from a...
Acute liver failure (ALF) is a serious inflammatory disorder with high mortality rates, which poses significant threat to human health. The IL-33/ST2 signal crucial regulator in inflammation responses associated lipopolysaccharide (LPS)-induced macrophages. IL-17A signaling pathway promotes the release of chemokines and cytokines, recruiting neutrophils T cells under LPS stimulation, thus facilitating responses. Here, potential therapeutic benefits neutralizing modulating ALF were...
To characterize BMI in Chinese patients with RA
Serum uric acid (SUA) acts as an antioxidant and abnormally low SUA may raise the risk of developing atherosclerotic disorders. There is a U-shaped association between with cardiovascular diseases (CVDs) in general population. However, prevalence hypouricemia its influence on CVDs rheumatoid arthritis (RA) remains unclear. This cross-sectional study collected clinical data from Chinese RA cohort. Hypouricemia was defined ≤ 3.0 mg/dL, hyperuricemia ≥ 7.0 mg/dL. were history angina pectoris,...
Our research aims to explore the therapeutic effect of circRNA02318 on MIRI rats and functional mechanism. The model was constructed in rats. CircRNA02318 overexpressing adenovirus injected situ during perfusion. H9C2 cells were treated with hypoxia for 6 h reoxygenation 3 h. Overexpression downregulated Drebrin, Nox1, cleaved caspase-3 Bax H/R rat heart tissues, promoted expression p-Akt/Akt Bcl-2, inhibited apoptosis cells. volume myocardial infarction release LDH TnI suppressed by...
Swertiamarin (STM) is a natural compound from Swertia mussotii Franch. (Gentianaceae) that exhibits various pharmacological effects. The current study tested the potential neuroprotective activity of STM in human neuroblastoma SH-SY5Y cells challenged with oxygen-glucose deprivation/reoxygenation (OGDR). Cell Counting Kit-8 assays were used to assess cell viability and JC-1 assay performed evaluate changes mitochondrial membrane (ΔΨm). intracellular levels ROS production measured by...
This study aims to investigate if addition of fibroblast-stromal cell markers a classification synovial pathotypes improves their predictive value on clinical outcomes in rheumatoid arthritis (RA). Active RA patients with knee needle biopsy at baseline and finished 1-year follow-up were recruited from real-world prospective cohort. Positive staining for CD20, CD38, CD3, CD68, CD31, CD90 scored semiquantitatively (0-4). The primary outcome was radiographic progression defined as minimum...
It is considered that circRNA can participate in regulating the occurrence and effects of ventricular arrhythmia (VA) through competing endogenous RNA (ceRNA) mechanism, pre-mRNA parental gene expression. Therefore, we used animal modeling high-throughput differential screening to screen out related VA study its possible mechanism action on VA.The rat model myocardial ischemia was established. High-throughput differentiated conducted verified by real-time quantitative polymerase chain...
To explore the menopause status of patients with rheumatoid arthritis (RA) and clinical characteristics perimenopausal RA patients.
Abstract The rhizosphere bacterium Pseudomonas protegens FD6, which is associated with the production of antibiotics such as pyoluteorin (PLT) and 2,4-diacetylphloroglucinol (2,4-DAPG), has strong antagonistic effects on phytopathogens. Hfq a conserved RNA chaperone involved in regulation stress tolerance, antibiotic production, bacterial virulence. Here, we determined regulatory biocontrol traits P. FD6. Mutation hfq FD6 reduced growth rate, swimming swarming ability, proteases,...
Objective To characterize the epidemiological characteristics of malignancy in Chinese patients with rheumatoid arthritis (RA) versus American and investigate their associated factors. Methods Data were collected from a real-world RA population National Health Nutritional Examination Survey. The prevalence subtypes potential factors investigated both populations. Results A total 2,073 2,928 included. There was lower than counterparts before (5.7% vs . 17.1%) after matching (6.2% 12.6%, P...
Objective: To investigate the characteristics of functional limitation and associated factors in patients with rheumatoid arthritis (RA). Methods: Consecutive RA were recruited from August 2015 to June 2019 at Department Rheumatology, Sun Yat-Sen Memorial Hospital. Demographic clinical including age, gender, erythrocyte sedimentation rate (ESR), visual analogue scale (VAS) pain, disease activity index (CDAI), modified total Sharp score collected. Physical function was assessed by Stanford...