A5041504875- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Bacterial biofilms and quorum sensing
- Antibiotic Resistance in Bacteria
- Electromagnetic Fields and Biological Effects
- T-cell and B-cell Immunology
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Nitric Oxide and Endothelin Effects
- Caveolin-1 and cellular processes
- Mast cells and histamine
- Cancer, Lipids, and Metabolism
- Effects of Radiation Exposure
- Genetic factors in colorectal cancer
- Protein Kinase Regulation and GTPase Signaling
- Toxoplasma gondii Research Studies
- Breast Cancer Treatment Studies
- Peroxisome Proliferator-Activated Receptors
- Alcohol Consumption and Health Effects
- Gastric Cancer Management and Outcomes
- Herpesvirus Infections and Treatments
- Reproductive System and Pregnancy
Zhongshan Hospital
2024-2025
Shanghai University
2025
Shanghai East Hospital
2021-2022
Tongji University
2021
Fudan University Shanghai Cancer Center
2013-2019
Jiading District Central Hospital
2017
Jiangsu University
2010-2016
Guangdong General Hospital
2015
Second Affiliated Hospital of Harbin Medical University
2013
Zhejiang Cancer Hospital
2013
Newly identified nuocytes or group 2 innate lymphoid cells (ILC2s) play an important role in Th2 cell mediated immunity such as protective immune responses to helminth parasites, allergic asthma, and chronic rhinosinusitis. However, the contributions of ILC2s occurrence development cancer remain unknown. Our previous study found that there was a predominant phenotype patients with gastric cancer. In this study, related genes molecules PBMC from were measured, potential correlation between...
Body mass index (BMI) and lipid parameters are the most commonly used anthropometric biomarkers for assessing nonalcoholic fatty liver disease (NAFLD) risk. This study aimed to assess quantify mediating role of traditional non-traditional on association between BMI NAFLD.Using data from 14,251 subjects NAGALA (NAfld in Gifu Area, Longitudinal Analysis) study, mediation analyses were performed explore roles [total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C),...
T helper 17(Th17) cell is a new subset of CD4+ cells that produce proinflammatory cytokine interleukin-17 (IL-17). Th17 have recently been shown to play critical role in many autoimmune diseases had previously thought be Th1 dominant. Although Hashimoto's thyroiditis (HT) was Th1-type disease, the contributions pathogenesis remain unclear. In this study, we investigated expression levels Th1/Th17 cell-associated factors peripheral blood mononuclear (PBMC) and plasma from patients with HT by...
Abstract This paper describes preliminary findings on the influence of 60‐Hz (2‐mT) magnetic fields tumor promotion and co‐promotion in skins mice. The effect natural killer (NK) cell activity spleen blood was also examined. Groups 32 juvenile female mice were exposed to field as described part I. dorsal skin all animals treated with a subthreshold dose carcinogen 7, 12‐dimethylbenz(a)anthracene (DMBA). One week after treatment, two groups sham (group A) or at 2 mT B) 6 h/day for 21 weeks,...
Osteoporosis (OP) is a systemic skeletal disorder characterized by decreased bone mineral density and heightened risk of fractures. Therapies for OP have primarily focused on balancing formation resorption, but enhancing the remineralization osteoporotic also key strategy effective repair. Recent insights into biomineralization mechanisms highlighted essential role mineral-containing extracellular vesicles (EVs) secreted osteoblasts in promoting marrow mesenchymal stromal/stem cell (BMSC)...
Solamargine (SM), a steroidal alkaloid glycoside extracted from the traditional Chinese herb Solanum incanum, has been evidenced to inhibit growth and induce apoptosis in number of human cancer cell lines. In present study, anticancer effect SM underlying molecular mechanism SM-induced were investigated on hepatocellular carcinoma cells, SMMC7721 HepG2. The proliferation effects HepG2 lines evaluated using MTT colony formation assays. addition, percentage was measured an Annexin V/propidium...
In recent years, T helper (Th) 9 cells have been demonstrated to be key mediators in immune responses asthmatic lungs, and innate lymphoid 2 (ILC2s) described as a novel type of immunocyte with the ability enhance immunoglobulin E (IgE) production. However, interaction between ILC2s Th9 pulmonary system mouse model asthma remains elucidated. present study, response state lung tissue regards was investigated by detecting Th9‑ ILC2‑associated cytokine receptors. The study also association...
Previous reports have revealed that down-regulation of miR-34a expression can promote colorectal cancer (CRC) cell growth by targeting cycle-related transcriptional factor E2F1. To date, the function single nucleotide polymorphism (SNP) located in mature region has not been investigated.We performed a case-control study including 685 CRC patients and 618 cancer-free controls. Genotyping, real-time PCR assay, transfection, dual luciferase reporter assay were used our study. Cell proliferation...
Osteoporosis (OP) is a systemic and retrogressive disease characterized by decreased bone density fragile microstructure. Extracellular vesicles (EVs), cell‐free system with phospholipid bilayer released cells that cannot be replicated, have unique nanostructure, stable drug‐loading capacity, good biocompatibility, playing an important role in regulating the gut‐skeletal axis. A growing body of research demonstrates gut microbiota (GM) influence development OS, while bacteria‐derived EVs...
To compare the levels of serum pepsinogen (PG) in patients with gastric cancer (GC), atrophic gastritis (AG), and healthy donors. Also, we explored clinical value PG detection for diagnosis treatment GC.The level peripheral blood from heathy donors was determined using an Abbott automatic chemiluminescence instrument. The study included 117 GC confirmed by gastroscopy histopathology, whom 13 had at stage I, 47 II, 41 III, 16 IV. AG group 122 patients, control 120 relationship between...
The dysregulation of nitric oxide (NO) synthesis attributable to the abnormal expression/activity endothelial NO synthase (eNOS) is considered be a major characteristic insulin-resistant states, as well an essential contributor pathogenesis cardiovascular diseases. Arg972 insulin receptor substrate-1 (IRS-1) associated with resistance. In present study, we investigated association between IRS-1 and eNOS in human subjects primary cultures cells. Data from 832 revealed that heterozygous...
Urinary tract infections (UTI) are commonest infections, especially in catheterized patients. It is responsible of mortality and morbidity among hospitalized The objectives the study were to demonstrate virulence factors their genes multi-drug resistance Pseudomonas aeruginosa causing UTI. A total 366 non-catheterized 171 patients' (in whom catheter was > 48 hours duration) urine samples (one sample/patient) from both sexes collected processed. >105 colony forming unit considered as...
Exposure to extremely low and frequency electromagnetic fields (ELF LF EMF) has been reported induce potent carcinogenic effects adverse pregnancy outcomes. DNA damage may be an EMF target site. This study investigates both 50 Hz 15.6 kHz magnetic on damagehepair in the normal human amniotic FL cell. The test of unscheduled synthesis (UDS) was utilized. In view weak fields, cells were simultaneously treated with methylnitro-nitrosoguanidine (MNNG), a known carcinogen. exposed sinusoidal...
Several recent reports have suggested the use of mean arterial blood pressure (MAP) to assess/predict risk developing atherosclerosis, chronic kidney disease, diabetes, metabolic syndrome, and poor prognosis in a variety cardiovascular cerebrovascular diseases. The current study aimed investigate association MAP with non-alcoholic fatty liver disease (NAFLD) explore differences this across populations.
<h3>Introduction/Background</h3> Glucose metabolism has been suggested as a therapeutic target in ovarian clear cell carcinoma (CCC). We attempted to clarify <sup>18</sup>F-FDG PET/CT-based metabolic metrics the recurrent CCC patients and their prognostic values. <h3>Methodology</h3> Quantitative parameters included maximum standardized uptake value (SUVmax), tumor volume (MTV) total lesion glycolysis (TLG). Two different methods were employed for defining threshold SUV delineate MTV: 1) of...
Objective: To identify the loss of heterozygosity (LOH) on chromosome 17p13.3 in ovarian cancer and cervical cancer. Methods: The frequency LOH DNA samples from 24 cancers, 9 13 non-malignant gynecological diseases were determined respectively, using Southern blot method with probe PYNZ.22. Results: was found 12 (50.0%) cancers (including a borderline mucinous cystadenoma), 4 (44.4%) carcinomas, 1 (7.7%) nonmalignant diseases, which intraepithelial neoplasm III (CIN III) (P<0.01)....
Abstract Purpose: Neoadjuvant chemotherapy may provide early indication of treatment response. Pathologic complete response (pCR) rate is a surrogate measure disease-free and overall survival. Anthracycline remain an important component regimen for breast cancer (BC), while adding taxane confers additional pCR rate. However the combination anthracycline trastuzumab controversial due to potential increased risk cardiac event. This trial was designed compare efficacy safety between...
<h3>Introduction/Background</h3> To study the kinetic profile and clinicopathological implication of squamous cell carcinoma antigen (SCC-Ag) in cervical cancer patients who underwent radical hysterectomy by a self-developed Single Molecule Assay (Simoa) immunoassay. <h3>Methodology</h3> We prospectively enrolled were scheduled for surgery between 2016/04 2017/06. Consecutive serum samples collected at five points: Day 0 (the day before surgery), 4 (post-operative 4), Week 2–4, Month 2–4...