A5101414303- Aquaculture Nutrition and Growth
- Glaucoma and retinal disorders
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Inflammasome and immune disorders
- Global Cancer Incidence and Screening
- Inflammatory mediators and NSAID effects
- Social Media in Health Education
- Advanced Fiber Optic Sensors
- Natural product bioactivities and synthesis
- Advanced Wireless Communication Technologies
- Aquaculture disease management and microbiota
- Cancer Genomics and Diagnostics
- Breast Lesions and Carcinomas
- Cancer-related molecular mechanisms research
- Stress Responses and Cortisol
- Prostate Cancer Treatment and Research
- Breast Cancer Treatment Studies
- Osteoarthritis Treatment and Mechanisms
- Structural Health Monitoring Techniques
- IgG4-Related and Inflammatory Diseases
- COVID-19 and healthcare impacts
- Health Literacy and Information Accessibility
New York University
2020-2025
Beijing Institute of Technology
2023-2025
Eye & ENT Hospital of Fudan University
2010-2024
Anhui University of Traditional Chinese Medicine
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Ocean University of China
2017-2023
University of Arkansas for Medical Sciences
2021-2023
Qingdao National Laboratory for Marine Science and Technology
2023
Qingdao University of Science and Technology
2023
Guangxi University
2023
Abstract Glucocorticoids (GCs) are the most prescribed anti-inflammatory and immunosuppressive drugs. However, their use is often limited by substantial side effects, such as GC-induced osteoporosis (GIO) with underlying mechanisms still not fully understood. In this study, we identify Tau a low-affinity binding receptor for GCs that plays crucial role in GIO. deficiency largely abolished bone loss induced high-dose dexamethasone, synthetic GC, both inflammatory arthritis GIO models....
Objectives Dysregulated chondrocyte metabolism is closely associated with the pathogenesis of osteoarthritis (OA). Suppressing catabolism to restore cartilage homeostasis has been extensively explored, whereas far less effort invested toward enhancing anabolism. This study aimed repurpose clinically approved drugs as potential stimulators anabolism in treating OA. Methods Screening a Food and Drug Administration-approved drug library; Assays for examining chondroprotective effects digoxin...
Algorithms derived from measurements of short-peptide (8–10 mers) binding to class I MHC proteins suggest that the groove a protein, such as K b , can bind well over 1 million different peptides with significant affinity (<500 nM), level ligand-binding promiscuity approaching heat shock protein unfolded proteins. can, nevertheless, discriminate between similar and many them high (nanomolar) affinity. Some insights into this high-promiscuity/high-affinity behavior its impact on...
Metabolites can double as a signaling modality that initiates physiological adaptations. Metabolism, chemical language encoding biological information, has been recognized powerful principle directing inflammatory responses. Cytosolic pH is regulator of response in macrophages. Here, we found L-malate exerts anti-inflammatory effect via BiP-IRF2BP2 signaling, which sensor cytosolic First, L-malate, TCA intermediate upregulated pro-inflammatory macrophages, was identified potent metabolite...
During the pathogenesis of retinitis pigmentosa (RP), roles retinal microglia cells after activation have not been totally elucidated. Herein, experimental RP was induced in SD rats by intraperitoneal injection N-methyl-N-nitrosourea (MNU) at 50mg/kg. The effects MNU on retinas were evaluated respectively histology and electroretinography (ERG) recordings serial time points. time-dependent gradual loss photoreceptor disrupted arrangement outer nuclear layer (ONL) significant reductions both...
Abstract In the brain, NLRP3 (Nucleotide‐binding oligomerization domain, leucine‐rich repeat, and pyrin‐domain‐containing 3) inflammasome is mainly expressed in microglia located hippocampus other mood‐regulated regions, which are particularly susceptible to stress. The activation of production products may contribute development depressive disorder memory deficits. Indoleamine 2, 3‐dioxygenase (IDO) a key factor mediating inflammation major (MDD). We here generated apoptosis‐associated...
Purpose The healthcare system across the world was forced to implement new policies, guidelines, and procedures due coronavirus disease 2019 (COVID-19) pandemic, which led many patients make an impossible choice about their health. For various reasons, chose remain at home delay any interaction medical facilities protect themselves or others from virus. Patients managing chronic diseases faced unprecedented challenges during this period, long-term effects on these patient populations...
This study aims to compare retinal vessel anatomy of normal rhesus monkeys and humans provide a basis from structural perspective for the use monkey as an experimental model in future studies vessels.The retinas six eyes eight human eyecups following corneal transplantation were obtained stained using adenosine diphosphatase methods. The distributions, orders, layers vessels perifoveal vascular ring compared.With staining, distinct fully discernable first order surrounding optic disc fifth...
Polyphyllin VII is an active compound isolated from Paris polyphylla, which termed Chonglou in China. The present study was designed to investigate the underlying mechanisms of antitumor effect lung cancer cells. cytotoxic human A549 cells analyzed; results revealed IC50 value 0.41±0.10 µM at 24 h. associated were investigated by phase‑contrast microscopy, fluorescence flow cytometry and western blot analysis. Exposure resulted apoptosis. Pyrrolidine dithiocarbamate (PDTC), inhibitor NF‑κB,...
Cartilage defects account for substantial economic and humanistic burdens pose a significant clinical problem. The efficacy of approaches to cartilage repair is often inadequate, in part, owing the restricted proliferative capacity chondrocytes. Molecules have promote differentiation multipotent mesenchymal stem cells into chondrocytes may also gain ability damaged cartilage. This study aimed investigate role Atsttrin (progranulin-derived engineered protein) as well signaling pathway...
Purpose: This study aimed to assess the expression of sterile alpha and TIR motif containing protein 1 (SARM1) in both chronic acute glaucomatous animal models investigate underlying SARM1-JNK signaling mechanism responsible for protective effects SARM1 downregulation on retinal ganglion cell (RGC) soma axons a intraocular hypertension (COH) model. Methods: The COH model was induced by injecting magnetic microbeads into anterior chamber, whereas created through ischemia–reperfusion (I/R)...
Abstract The actual combustion rate of pulverized coal in the blast furnace tuyere is hard to be measured. In this research, injected into oxygen was obtained by a new equipment. This equipment can simulate well, and relationship between injection (PCI) ratio A O/C established mathematical deduction. experimental results show that best combustibility four coals C, when 350 kg/tHM, reached 79%, while B same case only 45.6%. With increase , relative amount increases, conditions become better,...
Plant lectins represent a major group of anti-nutritional factors that can be toxic to human and animals. However, the mechanisms by which regulate cell fates are not well understood. In present study, cellular molecular impacts three common lectins, agglutinins from wheat germ [WGA (wheat agglutinin)], soybean [soybean agglutinin (SBA)] peanut [peanut (PNA)] were examined in zebrafish embryo liver cells. WGA SBA found induce apoptosis both vitro vivo, while PNA stimulated proliferation....
Abstract Receptor tyrosine kinases (RTK) have been the most prevalent therapeutic targets in anti-cancer drug development. However, emergence of resistance toward single target RTK inhibitors remains a major challenge to achieve long-term remissions. Development alternative inhibitory strategies that bypass is much wanted. In present study, we found selected cell surface RTKs were inhibited and crosslinked into detergent resistant complexes by oligomeric but not monomeric concanavalin A...
The degree of the over-consolidation ratio (OCR) silty clay affects soil’s mechanical properties and in situ test results. present study utilized numerical analysis to investigate behavior cone penetration pore pressure dissipation typical soils, while also taking into account impact (OCR). Effective stress finite-element analyses, which accounted for considerable deformation, were carried out at various OCRs. model assumed soil as a homogeneous material obeying modified Cam Clay (MCC)...