A5019328677- Bone Metabolism and Diseases
- Vitamin D Research Studies
- Adipose Tissue and Metabolism
- NF-κB Signaling Pathways
- Parathyroid Disorders and Treatments
- Bone and Joint Diseases
- Fibroblast Growth Factor Research
- Erythrocyte Function and Pathophysiology
- Hematological disorders and diagnostics
- Hemoglobinopathies and Related Disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Muscle Physiology and Disorders
- Renal and related cancers
- Bone health and treatments
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Estrogen and related hormone effects
- Cytokine Signaling Pathways and Interactions
- Lipid metabolism and biosynthesis
- Diabetic Foot Ulcer Assessment and Management
- Digestive system and related health
- Lipid metabolism and disorders
- Tissue Engineering and Regenerative Medicine
- RNA Research and Splicing
- Histiocytic Disorders and Treatments
Yale University
2012-2025
University of Wisconsin–Madison
2006-2009
Abstract Glucocorticoids (GCs) are the most prescribed anti-inflammatory and immunosuppressive drugs. However, their use is often limited by substantial side effects, such as GC-induced osteoporosis (GIO) with underlying mechanisms still not fully understood. In this study, we identify Tau a low-affinity binding receptor for GCs that plays crucial role in GIO. deficiency largely abolished bone loss induced high-dose dexamethasone, synthetic GC, both inflammatory arthritis GIO models....
Receptor activator of nuclear factor-κB ligand (RANKL) is essential for osteoclast differentiation, and hormones cytokines that stimulate bone resorption increase RANKL expression in stromal/osteoblastic cells. We have previously shown PTH 1,25-dihydroxyvitamin D3 control murine gene vitro, part, via an evolutionarily conserved transcriptional enhancer, designated the distal region (DCR), located 76 kb upstream from transcription start site. Herein we describe phenotype mice lacking this...
The skeleton is a direct target of vitamin D action, where the hormone modulates proliferation osteoblast precursors, their differentiation into mature osteoblasts, and functional activity. Some these effects are reminiscent those orchestrated by Wnt signaling pathway wherein stimulation membrane receptor Frizzled its coreceptor LRP5 leads to activation β-catenin subsequent transcription-mediated changes in biology. Indeed, now known play particularly important role bone formation such that...
We previously reported that mice deficient for the transcription factor early B-cell (Ebf1) exhibit markedly increased numbers of osteoblasts, bone formation rate, and serum osteocalcin, but marrow Ebf1−/− is also striking in its adiposity. The purpose this work was to analyze metabolic phenotype accompanies altered morphology mice. Whereas adiposity increased, deposition white adipose tissue other regions body severely reduced (sc 40–50%, abdominally 80–85%). Brown exhibited decreased lipid...
Selective estrogen receptor modulators (SERMs), such as tamoxifen (TAM), have been used extensively for the treatment and prevention of breast cancer other pathologies associated with aberrant (ER) signaling. These compounds exhibit cell-selective agonist/antagonist activities a consequence their ability to induce different conformational changes in ER, thereby enabling it recruit functionally distinct transcriptional coregulators. However, observation that SERMs can also regulate aspects...
FGF-23 has arisen as an early biomarker of renal dysfunction, but at the onset chronic kidney disease (CKD), data suggest that may be produced independently parathyroid hormone (PTH), 1,25(OH)2 -vitamin D3 signaling axis. Iron status is inversely correlated to level circulating FGF-23, and improvement in iron bioavailability within patients correlates with a decrease FGF-23. Alternately, recent evidence also supports regulatory role inflammatory cytokines modulation expression. To determine...
Significance Statement The specific mechanisms regulating formation of the glomerular tuft during renal development are largely unknown. A previous study showed transcription factor Early B cell 1 (EBF1) is essential for tuft. However, types driving developmental defects in mice lacking EBF1 were not identified. authors show that deletion from mesangium results impaired development, whereas podocytes does cause abnormalities. They mesangial cells directs capillary branching through NFAT...
Osteoclasts are large multinucleated, bone-resorbing cells derived from hematopoietic precursors in response to receptor activator of nuclear factor-kappaB ligand (RANKL). RANKL activates a number signal transduction pathways, which stimulate, turn, series specific transcription factors that initiate the process osteoclastogenesis. Perhaps most important these is factor activated T cytoplasmic 1 (NFATc1), DNA-binding protein upon activation translocates nucleus where it stimulates...
Chimeric antigen receptor T cell (CART) therapy, administration of certain cell-agonistic antibodies, immune check point inhibitors, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) and Toxic shock syndrome (TSS) streptococcal as well staphylococcal superantigens share one common complication, that is cell-driven cytokine release (CRS) accompanied multiple organ dysfunction (MOD). It not understood whether the failure a particular...
Abstract Iron deficiency is a potent stimulator of fibroblast growth factor 23 (FGF23), hormonal regulator phosphate and vitamin D metabolism, that classically thought to be produced by bone-embedded osteocytes. Here, we show iron-deficient transmembrane serine protease 6 knockout (Tmprss6–/–) mice exhibit elevated circulating FGF23 Fgf23 messenger RNA (mRNA) upregulation in the bone marrow (BM) but not cortical bone. To clarify sites promoter activity Tmprss6–/– mice, introduced...