A5038889478- Spinal Cord Injury Research
- MicroRNA in disease regulation
- Cytokine Signaling Pathways and Interactions
- Bone Metabolism and Diseases
- Neurogenesis and neuroplasticity mechanisms
- Signaling Pathways in Disease
- Protein Kinase Regulation and GTPase Signaling
- Mesenchymal stem cell research
- Cervical and Thoracic Myelopathy
- Neuroinflammation and Neurodegeneration Mechanisms
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- PARP inhibition in cancer therapy
- Nerve injury and regeneration
- RNA Interference and Gene Delivery
- interferon and immune responses
- NF-κB Signaling Pathways
- S100 Proteins and Annexins
- Inflammatory mediators and NSAID effects
- FOXO transcription factor regulation
- Medicinal Plants and Bioactive Compounds
- Sphingolipid Metabolism and Signaling
- Carbon and Quantum Dots Applications
- TGF-β signaling in diseases
- Heat shock proteins research
New York University
2017-2025
Shandong First Medical University
2020-2025
Guilin Tourism University
2024
Yantai University
2023
Jinan Central Hospital
2014-2022
Columbia University Irving Medical Center
2017-2021
Shandong University
2014-2021
Northwest Normal University
2021
New York Academy of Sciences
2020
Albert Einstein College of Medicine
2020
Abstract Purpose Spinal cord injury (SCI) often results in significant and catastrophic dysfunction disability imposes a huge economic burden on society. This study aimed to determine whether progranulin (PGRN) plays role the progressive damage following SCI evaluate potential for development of PGRN derivative as new therapeutic target SCI. Methods PGRN-deficient ( Gr −/− ) wild-type (WT) littermate mice were subjected using weight-drop technique. Local expression was evaluated by Western...
Abstract Glucocorticoids (GCs) are the most prescribed anti-inflammatory and immunosuppressive drugs. However, their use is often limited by substantial side effects, such as GC-induced osteoporosis (GIO) with underlying mechanisms still not fully understood. In this study, we identify Tau a low-affinity binding receptor for GCs that plays crucial role in GIO. deficiency largely abolished bone loss induced high-dose dexamethasone, synthetic GC, both inflammatory arthritis GIO models....
Little regeneration of transected axons occurs after the damage caused by traumatic spinal cord injury (SCI), and unidirectional irreversible fibrotic scars are thought to be main chemical physical obstacle for axonal regrowth in SCI pathology.We previously demonstrated that microRNA (miR)-21-5p transforming growth factor (TGF)-β1, a central pathological mediator diseases, were significantly up-regulated lesion epicenter SCI.Here, we found TGF-β1 enhanced miR-21-5p expression primary...
Ischemic spinal cord injury (ISCI) results in the motor sensory dysfunction of limbs below site. In response to injury, astrocytes develop into neuroprotective [(neurotrophic reactive (A2s)] mitigate damage. MicroRNA (miR)-21 can promote development neuroinflammation previous studies. Our aim was investigate effect miR-21 on its polarization. We used abdominal aortic occlusion model vivo. Immunohistochemistry detect distribution A2s cord. an oxygen glucose deprivation method ischemia vitro...
Astrogliosis following spinal cord injury (SCI) was considered as a negative factor for neural regeneration. We found that miR-21 significantly upregulated after SCI. So, we aim to determine whether acts in positive manner post In vitro, measured the proliferation, apoptosis and cytokine secretion of primary cultured astrocytes modulating expression by western blot, RT-PCR immunofluorescence. vivo, performed modified Allen's weight drop model. Manipulation level achieved interfering with...
Rutin has anti-inflammatory, antioxidant, anti-viral, anti-tumor and immune regulatory effects. However, the neuroprotective effects of rutin in spinal cord injury are unknown. The p38 mitogen activated protein kinase (p38 MAPK) pathway is most important member MAPK family that controls inflammation. We assumed mechanism repair associated with inhibition pathway. Allen's method was used to establish a rat model injury. intraperitoneally injected (30 mg/kg) for 3 days. After treatment rutin,...
Objectives Osteoarthritis (OA) is the most common joint disease; however, indeterminate nature of mechanisms by which OA develops has restrained advancement therapeutic targets. TNF signalling been implicated in pathogenesis OA. TNFR1 primarily mediates inflammation, whereas emerging evidences demonstrate that TNFR2 plays an anti-inflammatory and protective role several diseases conditions. This study aims to decipher chondrocytes Methods Biochemical copurification proteomics screen were...
To obtain microwave-absorbing materials with high absorptivity, broad bandwidth, and lightweight properties, Co3O4/lotus seedpod carbon (Co3O4/LSC) composites were reduced under a hydrogen pressure of 3 MPa. As the reduction temperature increases, phases Co3O4/LSC change from Co3O4 to CoO/Co. At 200 °C (named as 3200 nanocomposite), partial changes CoO, completely transfers into CoO little Co detectable at 300 (3300 concentration increases more than that 3300 nanocomposite once is raised 400...
Objective Tumour necrosis factor alpha (TNF-α) signalling plays a central role in the pathogenesis of various autoimmune diseases, particularly inflammatory arthritis. This study aimed to repurpose clinically approved drugs as potential inhibitors TNF-α treatment Methods In vitro and vivo screening an Food Drug Administration (FDA)-approved drug library; assays for examining blockade TNF actions by fexofenadine: defining anti-inflammatory activity fexofenadine using transgenic (TNF-tg) mice...
Spinal cord injury (SCI) is a complex pathological change that includes primary SCI and gradually evolves into secondary SCI. Accumulating evidence demonstrates circular RNAs (circRNAs) are involved in the pathology of variety neurological diseases injuries. However, characteristics function circRNAs have yet to be elucidated. Although previous research demonstrated circPrkcsh induces astrocytes produce inflammatory factors chemokines, precise mechanism microglia after remains unknown. In...
Objective: Fexofenadine (FFD) is an antihistamine drug with anti-inflammatory effect. The intervertebral disc (IVD) degeneration process involved in inflammation which tumor necrosis factor-α (TNF-α) plays important role. This study aims to investigate the role of FFD pathological IVD degeneration. Methods: Safranin O staining was used for measurement cartilageous tissue disc. Hematoxylin-Eosin (H&E) determine construction. A rat needle puncture model taken advantage examine vivo ....
Neural Regeneration Research: December 2015 - Volume 10 Issue 12 p 1953-1975 doi: 10.4103/1673-5374.172314
p204, a murine member of an interferon-inducible p200 family, was reported to recognize intracellular viral and bacterial DNAs, however, its role in the innate immunity vivo remains unknown due lack p204-deficient animal models. In this study we first generated p204−/− mice. Unexpectedly, p204 deficiency led significant defect extracellular LPS signaling macrophages, as demonstrated by dramatic reductions LPS-mediated IFN-β pro-inflammatory cytokines. The serum levels cytokines were also...
ZnO nanoparticles in a spherical-like structure were synthesized via filtration and calcination methods, different amounts of added to MgH2 ball milling. The SEM images revealed that the size composites was about 2 μm. states composed large particles with small covering them. After absorption desorption cycle, phase changed. MgH2-2.5 wt% composite reveals excellent performance among three samples. results show sample can swiftly absorb 3.77 H2 20 min at 523 K even 473 for 1 h 1.91 H2....
Abstract Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by insulin deficiency, and patients with have increased risk of bone fracture significantly impaired healing. Proinflammatory cytokine tumor necrosis factor‐alpha upregulated in diabetic fractures believed to underlie delayed healing commonly observed diabetes. Our previous genetic screen for the binding partners progranulin (PGRN), a growth factor‐like molecule that induces chondrogenesis, led identification...
Abstract Background Penfluridol, isolated from an FDA-approved small-molecule drug library as inhibitor of tumor necrosis factor α (TNFα)-stimulated NF-κB activation, is clinically used to treat chronic schizophrenia and related disorders. This study aimed investigate the therapeutic effect penfluridol on TNFα-stimulated inflammatory autoimmune diseases, particularly arthritis. Methods Various in vitro studies confirm inhibitory TNFα-induced activity bone marrow-derived macrophages or Raw...
Abstract Objective Novel therapeutic strategies are emerging with the increased understanding of underlying mechanisms human osteosarcoma. This current study tends to decipher potentially critical role DEP domain‐containing 1 (DEPDC1), a tumor‐related gene, during progression Methods Bioinformatics analysis 25,035 genes from National Center for Biotechnology Information (NCBI) databases was performed screen differentially expressed between osteosarcoma and normal control groups, complemented...