A5004656133- Cancer-related molecular mechanisms research
- Rheumatoid Arthritis Research and Therapies
- Osteoarthritis Treatment and Mechanisms
- Spondyloarthritis Studies and Treatments
- Inflammatory mediators and NSAID effects
- Autoimmune and Inflammatory Disorders Research
- Paraquat toxicity studies and treatments
- Selenium in Biological Systems
- Sperm and Testicular Function
- Pharmacological Effects of Natural Compounds
- Gout, Hyperuricemia, Uric Acid
- Mycobacterium research and diagnosis
- Traditional Chinese Medicine Studies
- Circular RNAs in diseases
- Inflammatory Biomarkers in Disease Prognosis
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- Cervical Cancer and HPV Research
- Advancements in Solid Oxide Fuel Cells
- Blood properties and coagulation
- Virus-based gene therapy research
- Macrophage Migration Inhibitory Factor
- Adenosine and Purinergic Signaling
- Gestational Diabetes Research and Management
- Cytomegalovirus and herpesvirus research
Anhui University of Traditional Chinese Medicine
2021-2025
Yichun University
2023-2024
Qidong Liver Cancer Prevention Research
2023
Hainan Medical University
2022
Hainan General Hospital
2022
New York University
2021
Nanchang University
2016-2019
81th Hospital of PLA
2015
Kingmed Diagnostics
2011
Xinfeng capsule is a traditional Chinese medicine compound, which has been clinically used for more than 20 years in the treatment of rheumatoid arthritis (RA), ankylosing spondylitis, osteoarthritis and its extracurricular lesions. However, molecular role XFC RA remains unclear.This study aims to explore efficacy potential mechanism through retrospective data mining analysis, animal experiments cell experiments.The effect on clinical laboratory indexes patients was observed using techniques...
Objectives Osteoarthritis (OA) is the most common joint disease; however, indeterminate nature of mechanisms by which OA develops has restrained advancement therapeutic targets. TNF signalling been implicated in pathogenesis OA. TNFR1 primarily mediates inflammation, whereas emerging evidences demonstrate that TNFR2 plays an anti-inflammatory and protective role several diseases conditions. This study aims to decipher chondrocytes Methods Biochemical copurification proteomics screen were...
Abstract The infinite-layer nickelates, proposed as analogs to superconducting cuprates, provide a promising platform for exploring the mechanisms of unconventional superconductivity. However, superconductivity has been exclusively observed in thin films under atmospheric pressure, underscoring critical role heterointerface. Here, we employed advanced Scanning Transmission Electron Microscopy-Electron Energy Loss Spectroscopy technique thoroughly investigate atomic configuration,...
Gouty arthritis (GA) is a characteristically inflammatory disease often associated with lipid metabolism disorder. Huangqin Qingrechubi capsule (HQC) has been used for the treatment of GA.To explore mechanism HQC in GA.A total 30 GA patients (GA group) and healthy subjects [normal control (NC) group] were recruited. The group was treated (3.6 g/d) 10 days. Lipid inflammation indexes detected. Five herbal names HQC, or 'gouty arthritis', 'hyperlipidemia' 'inflammation' as key words to search...
Abstract Objective This study aims to investigate the correlation of long non-coding RNA HOX transcript antisense (lncRNA HOTAIR) with PTEN/PI3K/AKT pathway and clinical-related indicators in osteoarthritis (OA) determine effect baicalin intervention. Methods The levels clinical lipid metabolism indexes immune-inflammatory OA patients normal controls was detected. chondrocytes (OA-CHs) were induced peripheral blood mononuclear cells (PBMCs), followed by treatment (50 ug/mL). RT-qPCR...
Abstract Background Abnormal expression of long noncoding RNAs (lncRNAs) is involved in several autoimmune diseases including rheumatoid arthritis (RA). In this study, we intended to explore the lncRNA LINC00638 RA and its potential mechanism action related inflammation oxidative stress. Methods The level peripheral blood mononuclear cells (PBMCs) obtained from 45 patients 30 normal controls was analyzed correlation with clinical indicators investigated. vitro, used tumor necrosis factor‐α...
This study examined the relationship of Sharp score with demographic factors and clinical immune-inflammatory markers in patients anemia rheumatoid arthritis (RA).The data 1057 RA 1006 without were retrospectively analyzed. Spearman's correlation coefficient analysis, association rule logistic regression used to relationships between influencing anemia.The incidence was 51.24% (1057/2063), mild accounted for 81.93% (866/1057) cases. analyses revealed that correlated response anemia. Logistic...
To investigate the expression of long non-coding RNA (lncRNA) Linc00638 in rheumatoid arthritis (RA) and its regulatory role inflammation oxidative stress synovial fibroblasts RA patients (RA-FLS).Peripheral blood mononuclear cells (PBMCs) were collected from 20 healthy individuals 35 for detecting using RT-qPCR to analyze correlation with clinical indicators patients. A overexpression plasmid siRNA targeting transfected into RA-FLS, changes cell viability was observed CCK8 assay; levels...
Objective. This study aimed to analyze the effect of traditional Chinese medicine (TCM) on risk readmission for rheumatoid arthritis (RA) patients with anemia. Methods. In this study, 893 hospitalized RA were followed up by telephone. A retrospective cohort was conducted using propensity score matching (PSM). The Cox proportional hazards model used assess influence various factors Kaplan–Meier survival curve utilized TCM intervention time readmission. Results. incidence anemia 58.08%...
To evaluate whether traditional Chinese medicine compound preparations (TCMCPs) are associated with rheumatoid arthritis- (RA-) related complications (including readmission, Sjogren's syndrome, surgical treatment, and all-cause death) in patients RA.Clinical outcome data were retrospectively collected from RA discharged the Department of Rheumatology Immunology First Affiliated Hospital Anhui University Medicine January 2009 to June 2021. The propensity score matching method was used match...
This study aimed to explore the correlation between traditional Chinese medicine(TCM) and reduced risk of readmission in patients having rheumatoid arthritis with hypoproteinemia(RA-H). A retrospective cohort was conducted on 2 437 information system database First Affiliated Hospital Anhui University Medicine from 2014 2021, 476 them were found have hypoproteinemia. The divided into TCM users non-TCM by propensity score matching. Exposure defined as use oral patent medicine or herbal...
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and joint destruction. Both inflammatory response oxidative stress contribute to the pathogenesis of RA. Oxidative damage can induce aggravate imbalance immune promote cell tissue damage. In this study, expression long non-coding RNA (lncRNA) LINC00638 in peripheral blood patients with RA damp-heat arthralgia syndrome was observed, correlation between activity, indicator investigated. Subsequently,...
Previous studies have found associations between polymorphisms in some candidate genes and chronic obstructive pulmonary disease (COPD) risk. However, the association TLR2 TLR9 COPD risk remains uncertain. Four variants (rs352140, rs3804099, rs3804100, rs5743705) of 540 patients 507 healthy controls were genotyped using Agena MassARRAY system. Odds ratio (OR) 95% confidence interval (CI) calculated to assess with by logistic regression analysis. TLR9-rs352140, TLR2-rs3804100, TLR2-rs5743705...
Objectives:To analyze the function and roles of circRNAs in peripheral blood mononuclear cells (PBMCs) ankylosing spondylitis (AS) patients. Methods: The expression AS-related were detected by high-throughput RNA-sequencing within PBMCs 5 AS cases healthy controls. After profiling circRNA these samples, differentially expressed (DECs) identified, a qPCR-based validation approach was used to confirm differential six DECs patient samples. Spearman’s correlation tests ROC curve analyses further...
There is a growing trend of applying traditional Chinese medicine (TCM) to treat immune diseases. This study reveals the possible mechanism luteolin, an active ingredient in core prescription TCM, alleviating systemic sclerosis (SSc) inflammation. Bibliometrics was performed retrieve keywords SSc The key inflammatory indicators serum samples 50 patients were detected by ELISA. Data mining applied for correlation analysis, association rule and binary logistic regression analysis on clinical...