A5101612042- Rheumatoid Arthritis Research and Therapies
- Traditional Chinese Medicine Studies
- Cancer-related molecular mechanisms research
- Pharmacological Effects of Natural Compounds
- Spondyloarthritis Studies and Treatments
- Circular RNAs in diseases
- Autoimmune and Inflammatory Disorders Research
- Osteoarthritis Treatment and Mechanisms
- Breast Cancer Treatment Studies
- Systemic Lupus Erythematosus Research
- RNA modifications and cancer
- Inflammatory mediators and NSAID effects
- Neurological Disease Mechanisms and Treatments
- Advanced Breast Cancer Therapies
- Traditional Chinese Medicine Analysis
- Drug-Induced Hepatotoxicity and Protection
- Nitric Oxide and Endothelin Effects
- Neuroinflammation and Neurodegeneration Mechanisms
- HER2/EGFR in Cancer Research
- MicroRNA in disease regulation
- Gut microbiota and health
- Stress Responses and Cortisol
- Climate Change and Health Impacts
- Natural Compounds in Disease Treatment
- Gout, Hyperuricemia, Uric Acid
Anhui University of Traditional Chinese Medicine
2018-2025
Harbin Medical University
2025
Union Hospital
2025
Huazhong University of Science and Technology
2025
Hohai University
2024
Peking University First Hospital
2017-2024
Peking University
2017-2024
Shandong Academy of Chinese Medicine
2023
Chinese Medical Association
2022
Defence Electronics Research Laboratory
2022
Circular RNAs (circRNAs) are a significant class of molecules involved in wide range diverse biological functions that abnormally expressed many types diseases. The present study aimed to determine the circRNAs specifically peripheral blood mononuclear cells (PBMCs) from rheumatoid arthritis (RA) patients identify their possible molecular mechanisms.To RA, we started by sequencing PBMCs circRNA and microRNAs (miRNAs) RA group (n = 3) control 3). We constructed network differentially miRNAs....
ObjectiveThe aim of this study was to investigate the relationship between Traditional Chinese medicine (TCM) and pain reduction, hospital readmission, joint replacement in patients with osteoarthritis (OA). herbal (CHM) prescription patterns were further analyzed confirm association prognosis quality life OA patients.MethodsWe retrospectively followed 3,850 hospitalized January 2018 December 2022 using hospital's HIS system. Propensity score matching (PSM) used for data matching. Cox's...
Introduction The pathological mechanisms of rheumatoid arthritis (RA) are closely associated with the apoptosis escape fibroblast-like synoviocytes (FLS). m6A modification long non-coding RNAs (lncRNAs) plays a critical regulatory role in RA pathogenesis. Xinfeng Capsule (XFC), clinically effective traditional Chinese medicine formulation, has been shown to alleviate by inhibiting FLS escape. However, its molecular remain unclear. This study aimed elucidate mechanism which demethylase FTO...
Objectives This study aimed to evaluate the caregiving burden among primary caregivers of cancer patients, clarify relationship between family resilience and burden, explore mediation moderation effects. Design A cross-sectional design was used. Setting The conducted at a specialised tumour hospital in Harbin, China. Participants included sample 402 patients with cancer. Ultimately, 367 participants completed valid questionnaires, yielding response rate 91.2%. Outcome measures scales...
The aim of this study is to investigate the implication Chinese herbal formula (CHF) Shenzhu tiaopi Granule (STG) in type 2 diabetes mellitus (T2DM) and discuss mechanisms by which STG regulates gut microbiota.Goto-Kakizaki (GK) rats age-matched Wistar (W) were acclimatized for 1 week. GK randomly divided into 3 groups orally gavaged with saline (model group, M), acarbose (acarbose A), (granule CHF G; component includes Codonopsis pilosula, Rhizoma Atractylodis, Pinellia, Poria cocos,...
Long noncoding RNAs (lncRNAs) are >200‐bp molecules that do not generally code for proteins. Human lncRNAs have well‐characterized roles in gene expression regulation, particularly with regard to protein‐coding genes, and their dysregulation has been linked disease. Here, we set out investigate changes the of related apoptosis autophagy peripheral blood mononuclear cells (PBMCs) rheumatoid arthritis (RA). In addition, aimed correlate lncRNA profiles clinical indexes self‐perception...
The American Joint Committee on Cancer (AJCC) released its 8th edition of tumor staging which is to be implemented in early 2018. present study aimed analyze the prognostic value AJCC Staging System HER2-enriched breast cancer, a retrospective cohort.This was single-center cancer cases diagnosed from January 2008 December 2014. Clinicopathological features and follow up data including disease-free survival (DFS) overall (OS) were analyzed explore factors for disease outcome. We restaged...
Rheumatoid arthritis (RA) is a chronic autoimmune disorder that diagnosed mainly on the basis of patient signs, symptoms, and laboratory indices. However, exact causes RA are unclear. Moreover, there lack any method dynamically evaluating efficacy medication administered to treat RA. Here, we applied random walk model reveal compatibility among various constituents traditional Chinese medicine evaluate their therapeutic against Drugs commonly used were investigated using cluster analysis....
The therapeutic effects of Huangqin Qingre Chubi (HQC) in rheumatoid arthritis (RA) have been documented. However, there is a lack real-world clinical evidence supporting its efficacy.Patients diagnosed with RA were recruited from the First Affiliated Hospital Anhui University Chinese Medicine. Patient information was obtained hospital's database. Propensity score matching (PSM), Kaplan-Meier curve, and Cox proportional hazards model used to control confounding factors analyze influencing...
In the present study, protective effects of luteolin were investigated against psychological stress-induced cognitive impairment. To emulate stress, mice received restraint stress for six hours daily, between 9:00 and 15:00 hours, 21 consecutive days. The results step-through test, open-field test Morris Water Maze demonstrated that treatment could result in impairments mice. This cognition dysfunction was improved by with low- medium-dose luteolin. addition, induced an increased serum...
Type 2 Diabetes Mellitus (T2DM) is a chronic disease closely related to personal life style. Therefore, achieving effective self-management one of the most important ways control it. There evidence that social support can help improve ability patients with T2DM, but which more has been rarely explored. The purpose this study construct an integrated model analyze significant impact on and provide reasonable suggestions health care providers how effectively play role support.We established...
This study aimed to ascertain the immuno-inflammatory molecular targets of Xinfeng capsules (XFC) in treatment ankylosing spondylitis (AS) based on data mining, network pharmacology, and docking.The efficacy XFC AS was assessed by clinical mining. Network pharmacology utilized establish a for active ingredients AS. The binding mode affinity key were predicted using docking.XFC significantly diminished indicators In total, 208 obtained from TCMSP database 629 disease screened GeneCards...
Osteoarthritis (OA) is a degressive and complex disease which growing public health problem on global scale. On basis of an in-house database consisting clinical records 13,083 OA patients, the Traditional Chinese Medicine (TCM) was divided into 4 categories medicines curative properties herbs. Due to lack depth internal relationship in calculation results TCM compatibility law data mining methods such as statistics frequency analysis, we use variety multidimensional network that can...
To investigate the role of m6A-mediated lncRNA MAPKAPK5-AS1 (MK5-AS1) in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) and its underlying molecular mechanism. RT-qPCR, western blot, flow cytometry (FCM), enzyme-linked immunosorbent assay (ELISA) were utilized for evaluating inflammation apoptosis. Next, RIP, RNA pull-down, dual-luciferase reporter gene assay, a series rescue experiments performed to explore regulatory mechanisms MK5-AS1 sponge-like action RA-FLSs. The...
Objective . To analyse the clinical features of diabetic peripheral neuropathy (DPN) and employ data mining technology to explore rules Chinese herbal medicine (CHM) therapy. Methods The 216 patients with DPN qi‐yin deficiency syndrome were obtained, assessed by cluster analysis. Relevant information was entered into diagnosis treatment collection system, techniques used drug frequency, core CHM, CHM pair, so on. Results In this study, glycated haemoglobin (HbA1c) homocysteine (HCY) closely...
Gastric cancer (GC) is a common with high incidence and mortality worldwide. In recent years, accumulating evidence has shown that long noncoding RNAs (lncRNAs) exert critical roles in the development progression of by acting as tumor initiator or suppressor. LINC00963 newly reported lncRNA related to cancer, its role GC remains unclear.The expression levels LINC00963, miR-612, cell division cycle 5-like protein (CDC5L) were measured using quantitative real-time PCR Western blot. The...
This study examined the relationship of Sharp score with demographic factors and clinical immune-inflammatory markers in patients anemia rheumatoid arthritis (RA).The data 1057 RA 1006 without were retrospectively analyzed. Spearman's correlation coefficient analysis, association rule logistic regression used to relationships between influencing anemia.The incidence was 51.24% (1057/2063), mild accounted for 81.93% (866/1057) cases. analyses revealed that correlated response anemia. Logistic...
Ankylosing spondylitis (AS) has a high disability rate, and an early diagnosis is difficult.To explore the possible functions underlying mechanism of circular RNAs Homo sapiens (hsa)_circ_0003307 in ankylosing spondylitis.The hsa_circ_0003307 expression levels were investigated peripheral blood mononuclear cells (PBMCs) 30 AS patients healthy controls (HC) using quantitative reverse transcription polymerase chain reaction (qRT-PCR) analysis. Primary fibroblast-like synoviocytes (FLS)...