A5075348344- Gut microbiota and health
- Traditional Chinese Medicine Studies
- Acupuncture Treatment Research Studies
- Healthcare and Venom Research
- Traditional Chinese Medicine Analysis
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Autoimmune and Inflammatory Disorders Research
- Atherosclerosis and Cardiovascular Diseases
- Metabolomics and Mass Spectrometry Studies
- Thermal Regulation in Medicine
- Berberine and alkaloids research
- Liver physiology and pathology
- Cervical and Thoracic Myelopathy
- Spine and Intervertebral Disc Pathology
- Climate Change and Health Impacts
- Drug-Induced Hepatotoxicity and Protection
- T-cell and B-cell Immunology
- Single-cell and spatial transcriptomics
- Diabetic Foot Ulcer Assessment and Management
- Vitamin K Research Studies
- Pain Mechanisms and Treatments
Anhui University of Traditional Chinese Medicine
2014-2025
Institute of Hydrobiology
2025
Peking University
2025
Chinese Academy of Sciences
2025
Qingdao Municipal Hospital
2024
Qingdao University
2024
Weatherford College
2022
Genetic Analysis (Norway)
2022
Ministry of Education of the People's Republic of China
2022
Effect of berberine on hyperglycaemia and gut microbiota composition in type 2 diabetic Goto-Kakizaki rats
ShenZhu TiaoPi granule (STG) is a compound prescription that used in Chinese medicine for the treatment of type 2 diabetes mellitus (T2DM). Previous studies have indicated hypoglycaemic effect, but underlying mechanism remains unclear. Goto-Kakizaki (GK) rats were to establish an vivo T2DM model (Mod). The metformin (Met) and STG time was 12 weeks. Fasting blood glucose (FBG) insulin levels area under curve (GAUC) measured. Intestinal pathology permeability observed. Microbial diversity...
Introduction Type 2 diabetes mellitus (T2DM) is a disease that involves autoimmunity. However, how immune cells function in the peripheral blood remains unclear. Exploring T2DM biomarkers via single-cell RNA sequencing (scRNA-seq) could provide new insights into underlying molecular mechanisms. Methods The clinical trial registration number ChiCTR2100049613. In this study, we included three healthy participants and patients. observed indicators weight fasting glucose (FBG), glycosylated...
Introduction The gut microbiota and bile acids (BAs) have emerged as factors involved in the development of non-alcoholic fatty liver disease (NAFLD). Xiaohua Funing decoction (XFD) is a traditional Chinese medicine formula used for treatment NAFLD. Previous studies indicated that XFD protects function, but underlying mechanism remains unclear. Methods In this study, Wistar rat model NAFLD (Mod) was established via high-fat diet. effects obeticholic acid (OCA) on Mod rats were subsequently...
The aim of this study is to investigate the implication Chinese herbal formula (CHF) Shenzhu tiaopi Granule (STG) in type 2 diabetes mellitus (T2DM) and discuss mechanisms by which STG regulates gut microbiota.Goto-Kakizaki (GK) rats age-matched Wistar (W) were acclimatized for 1 week. GK randomly divided into 3 groups orally gavaged with saline (model group, M), acarbose (acarbose A), (granule CHF G; component includes Codonopsis pilosula, Rhizoma Atractylodis, Pinellia, Poria cocos,...
Abstract Background Clinical studies have shown that diabetic peripheral neuropathy (DPN) has been on the rise, with most patients presenting severe and progressive symptoms. Currently, of available prediction models for DPN are derived from general clinical information laboratory indicators. Several Traditional Chinese medicine (TCM) indicators utilised to construct models. In this study, we established a novel machine learning‐based multi‐featured Chinese–Western medicine‐integrated model...
The purpose of the study was to evaluate clinical effects Shenzhu Tiaopi granule (SZTP) combined with a lifestyle intervention in patients impaired glucose tolerance (IGT), who also had spleen deficiency and damp overabundance syndrome (SDDOS). After one-month washout period, total 514 were randomly assigned control (lifestyle intervention) experimental (SZTP plus groups, 257 each group. Patients group received (diet exercise) for 12 months, while treated SZTP months. Traditional Chinese...
Objective . To analyse the clinical features of diabetic peripheral neuropathy (DPN) and employ data mining technology to explore rules Chinese herbal medicine (CHM) therapy. Methods The 216 patients with DPN qi‐yin deficiency syndrome were obtained, assessed by cluster analysis. Relevant information was entered into diagnosis treatment collection system, techniques used drug frequency, core CHM, CHM pair, so on. Results In this study, glycated haemoglobin (HbA1c) homocysteine (HCY) closely...
Abstract Background Teriparatide (TPTD) is a widely used anabolic agent for the treatment of osteoporosis. Several factors have been identified to be related bone mineral density (BMD) increase in anti-osteoporosis with other agents; however, there has no systematic analysis summarize associated determinants BMD reaction daily teriparatide treatment. Methods In this retrospective study, we performed comprehensive investigation involving not only clinical data but also several relevant...
Background/Aims: To investigate the potential therapeutic effect of novel polysaccharide H-1-2 from pseudostellaria heterophylla against type 2 Diabetes Mellitus (T2DM) and elucidate underling molecular mechanisms. Methods: Relative expression HIF1α Sirt1 in T2DM patients was determined via real-time PCR. The direct binding on promoter validated by ChIP assay. inhibitory regulation analyzed using luciferase reporter endogenous protein response to treatment quantified western blotting. blood...
Diabetic neuropathic pain (DNP) is one of the most common chronic peripheral neuropathies in diabetes mellitus (DM). Objective. To observe underlying mechanism effects Yiqi Huoxue Tongluo Decoction (YQHX) on DNP rats. Methods. SD rats were intraperitoneally injected with 35 mg/kg streptozotocin (STZ) to prepare models and treated YQHX for 8 weeks. Results. Studies have shown that drug restores some levels MWT, TWL, MNCV, downregulates inflammatory factors IL-6, IL-1β, TNF-α, ASK1-MKK3-p38,...
To evaluate the clinical effects of Xiyanping injection intervention in pediatric patients with mild hand foot and mouth disease (HFMD).A total 329 were stratified block-randomized for symptomatic treatment HFMD assigned to one following groups: Western Medicine (group A, n = 103), B, 109), or using C, 117). During trial, fever, rash, ulcers observed among participants each group before after treatment, conversion rates from severe measured.After 3-7 days' no significant differences three...
The aim of this study was to evaluate the effects a modified Xiaohua Funing decoction (Xfd) on acute liver failure (ALF) and determine whether protective mechanisms are related alterations in gut microbiota.An animal model ALF induced by intraperitoneal injection D-galactosamine (D-Gal, 0.5 g/kg) lipopolysaccharide (LPS, 100 μg/kg). Male BALB/c mice were randomly divided into following 4 groups: control group (saline, Con), (D-Gal/LPS, Mod), silymarin pretreatment (200 mg/kg, Sil), Xfd (650...
ABSTRACT Objective Type 2 diabetes mellitus (T2DM) is a complex polygenic disease. The onset of the disease related to autoimmunity. However, how immune cells function in peripheral blood remains be elucidated. Metformin first-line treatment. Exploring biomarkers T2DM based on single-cell sequencing technology can provide new insights for discovery metformin treatment molecular mechanisms. Methods We profiled 43,971 and 20,228 genes from mononuclear (PBMCs) patients healthy controls by...
Objective To observe the effect of Danzhi Jiangtang capsule (DJC) on clinical indexes and vascular endothelial function in patients with impaired glucose tolerance (IGT).