A5100384662- Lipid metabolism and disorders
- Cancer, Hypoxia, and Metabolism
- Cardiomyopathy and Myosin Studies
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Congenital heart defects research
- Cardiac Fibrosis and Remodeling
- Muscle Physiology and Disorders
- Renin-Angiotensin System Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Genetic factors in colorectal cancer
- Traditional Chinese Medicine Studies
- Cardiovascular Effects of Exercise
- Vitamin K Research Studies
- Cardiac Ischemia and Reperfusion
- Cardiovascular Disease and Adiposity
- Single-cell and spatial transcriptomics
- Peroxisome Proliferator-Activated Receptors
- CRISPR and Genetic Engineering
- Nitric Oxide and Endothelin Effects
- Heart Failure Treatment and Management
- Metabolism and Genetic Disorders
- Pluripotent Stem Cells Research
- Acupuncture Treatment Research Studies
- Glycosylation and Glycoproteins Research
The University of Texas MD Anderson Cancer Center
2024
The University of Texas Health Science Center at Houston
2022-2024
XinHua Hospital
2022
Shanghai Jiao Tong University
2022
Xi'an Jiaotong University
2022
Xi’an Children’s Hospital
2022
Weatherford College
2021
TEDA International Cardiovascular Hospital
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Jinshan Hospital of Fudan University
2019
Adiponectin is an important adipocytokine and has been associated with the risks of gastrointestinal cancers (GICs). Mendelian randomization (MR) analysis needed to assess causal relationships between adiponectin GICs.We retrieved summary data genome-wide association studies for six types GICs in East Asians. A series quality control steps were performed select eligible genetic instrumental tools. Horizontal pleiotropy between-SNP heterogeneity tested choose primary MR method. We also...
Article18 September 2019Open Access Source DataTransparent process Nuclear receptor corepressor 1 represses cardiac hypertrophy Chao Li orcid.org/0000-0002-2060-4835 Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People's Hospital, College Stomatology, Jiao Tong University School Medicine, Shanghai, China National Clinical Research Center for Key Stomatology & Institute Division Cardiology, Department Internal Texas Southwestern Medical Center, Dallas, TX, USA Search...
The purpose of the study was to evaluate clinical effects Shenzhu Tiaopi granule (SZTP) combined with a lifestyle intervention in patients impaired glucose tolerance (IGT), who also had spleen deficiency and damp overabundance syndrome (SDDOS). After one-month washout period, total 514 were randomly assigned control (lifestyle intervention) experimental (SZTP plus groups, 257 each group. Patients group received (diet exercise) for 12 months, while treated SZTP months. Traditional Chinese...
Previously we showed the generation of a protein trap library made with gene-break transposon (GBT) in zebrafish ( Danio rerio ) that could be used to facilitate novel functional genome annotation towards understanding molecular underpinnings human diseases (Ichino et al, 2020). Here, report significant application this for discovering essential genes heart rhythm disorders such as sick sinus syndrome (SSS). SSS is group caused by malfunction node, heart’s primary pacemaker. Partially owing...
Objective: Our study aims to summarize and analyze the clinical characteristics of transient infantile hypertriglyceridemia (HTGTI) variants in glycerol-3-phosphate dehydrogenase 1 (GPD1) gene effect HTGTI on protein structure GPD1. Methods: Retrospective analysis, using general data, symptoms, signs, auxiliary examinations, was performed patients with HTGTI, which were confirmed by genetic testing our hospital reported cases online. The data analyzed statistical bioinformatic approaches....
Hyperhomocysteinemia is an independent risk factor for atherosclerotic heart disease. We previously demonstrated that disruption of calcium-activated potassium (KCa) channel activity involved in homocysteine-induced dilatory dysfunction porcine coronary arteries. Recently we reported the KCa family, including large-, intermediate-, and small-conductance (BKCa, IKCa, SKCa) subtypes, are abundantly expressed human internal mammary artery (IMA). In this study, further investigated whether...
Transient infantile hypertriglyceridemia (HTGTI) is a rare autosomal recessive inherited disease caused by inactivating mutations in the glycerol-3-phosphate dehydrogenase 1 gene. To date, only few patients have been reported worldwide. The symptoms of affected individuals present certain degree transient hypertriglyceridemia, hepatomegaly, elevated liver enzymes, persistent fatty and hepatic fibrosis early infancy. However, clinical characteristics pathogenesis this are remain unclear.A one...
Whether afferents exert their morphogenetic influence on spindles through release of trophic factors at intrafusal fiber junctions or via participation in proprioceptive pathways which modulate the motor activity to muscles was investigated by comparing myosin heavy chain (MHC) expression fibers after ablation (deafferentation, DA) extensor digitorum longus (EDL) adult rats corresponding central processes spinal cord (central-process ablation, CPA). DA and CPA elicited an exaggerated pedal...