A5078848059- Rheumatoid Arthritis Research and Therapies
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Autoimmune and Inflammatory Disorders Research
- Spondyloarthritis Studies and Treatments
- Traditional Chinese Medicine Studies
- Pharmacological Effects of Natural Compounds
- Systemic Lupus Erythematosus Research
- Natural Compounds in Disease Treatment
- Mycobacterium research and diagnosis
- Osteoarthritis Treatment and Mechanisms
- Musculoskeletal synovial abnormalities and treatments
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- RNA modifications and cancer
- Inflammatory mediators and NSAID effects
- RNA Research and Splicing
- Gout, Hyperuricemia, Uric Acid
- Toxin Mechanisms and Immunotoxins
- Healthcare and Venom Research
- Machine Learning in Bioinformatics
- interferon and immune responses
- Clusterin in disease pathology
- Hepatitis C virus research
- Traditional Chinese Medicine Analysis
Anhui University of Traditional Chinese Medicine
2019-2025
Xinfeng capsule is a traditional Chinese medicine compound, which has been clinically used for more than 20 years in the treatment of rheumatoid arthritis (RA), ankylosing spondylitis, osteoarthritis and its extracurricular lesions. However, molecular role XFC RA remains unclear.This study aims to explore efficacy potential mechanism through retrospective data mining analysis, animal experiments cell experiments.The effect on clinical laboratory indexes patients was observed using techniques...
Circular RNAs (circRNAs) are a significant class of molecules involved in wide range diverse biological functions that abnormally expressed many types diseases. The present study aimed to determine the circRNAs specifically peripheral blood mononuclear cells (PBMCs) from rheumatoid arthritis (RA) patients identify their possible molecular mechanisms.To RA, we started by sequencing PBMCs circRNA and microRNAs (miRNAs) RA group (n = 3) control 3). We constructed network differentially miRNAs....
Introduction The pathological mechanisms of rheumatoid arthritis (RA) are closely associated with the apoptosis escape fibroblast-like synoviocytes (FLS). m6A modification long non-coding RNAs (lncRNAs) plays a critical regulatory role in RA pathogenesis. Xinfeng Capsule (XFC), clinically effective traditional Chinese medicine formulation, has been shown to alleviate by inhibiting FLS escape. However, its molecular remain unclear. This study aimed elucidate mechanism which demethylase FTO...
Rheumatoid arthritis (RA), recognized as a common chronic autoimmune disease, is characterized by the excessive proliferation and inflammatory infiltration of fibroblast‐like synoviocytes (FLS). In this study, our purpose to elucidate mechanisms triptolide (TPL) in treatment RA regulating long non‐coding RNA (lncRNA) ENST00000619282, which promoted apoptosis reduced FLS (RA‐FLS). RA‐FLS was treated with different concentrations TPL at time points. CCK‐8 assay, ELISA, RT‐qPCR,...
Abstract Objective This study aims to investigate the correlation of long non-coding RNA HOX transcript antisense (lncRNA HOTAIR) with PTEN/PI3K/AKT pathway and clinical-related indicators in osteoarthritis (OA) determine effect baicalin intervention. Methods The levels clinical lipid metabolism indexes immune-inflammatory OA patients normal controls was detected. chondrocytes (OA-CHs) were induced peripheral blood mononuclear cells (PBMCs), followed by treatment (50 ug/mL). RT-qPCR...
Long noncoding RNAs (lncRNAs) are >200‐bp molecules that do not generally code for proteins. Human lncRNAs have well‐characterized roles in gene expression regulation, particularly with regard to protein‐coding genes, and their dysregulation has been linked disease. Here, we set out investigate changes the of related apoptosis autophagy peripheral blood mononuclear cells (PBMCs) rheumatoid arthritis (RA). In addition, aimed correlate lncRNA profiles clinical indexes self‐perception...
Abstract Background Abnormal expression of long noncoding RNAs (lncRNAs) is involved in several autoimmune diseases including rheumatoid arthritis (RA). In this study, we intended to explore the lncRNA LINC00638 RA and its potential mechanism action related inflammation oxidative stress. Methods The level peripheral blood mononuclear cells (PBMCs) obtained from 45 patients 30 normal controls was analyzed correlation with clinical indicators investigated. vitro, used tumor necrosis factor‐α...
Rheumatoid arthritis (RA) is a chronic autoimmune disorder that diagnosed mainly on the basis of patient signs, symptoms, and laboratory indices. However, exact causes RA are unclear. Moreover, there lack any method dynamically evaluating efficacy medication administered to treat RA. Here, we applied random walk model reveal compatibility among various constituents traditional Chinese medicine evaluate their therapeutic against Drugs commonly used were investigated using cluster analysis....
This study aimed to ascertain the immuno-inflammatory molecular targets of Xinfeng capsules (XFC) in treatment ankylosing spondylitis (AS) based on data mining, network pharmacology, and docking.The efficacy XFC AS was assessed by clinical mining. Network pharmacology utilized establish a for active ingredients AS. The binding mode affinity key were predicted using docking.XFC significantly diminished indicators In total, 208 obtained from TCMSP database 629 disease screened GeneCards...
Osteoarthritis (OA) is a degressive and complex disease which growing public health problem on global scale. On basis of an in-house database consisting clinical records 13,083 OA patients, the Traditional Chinese Medicine (TCM) was divided into 4 categories medicines curative properties herbs. Due to lack depth internal relationship in calculation results TCM compatibility law data mining methods such as statistics frequency analysis, we use variety multidimensional network that can...
To investigate the role of m6A-mediated lncRNA MAPKAPK5-AS1 (MK5-AS1) in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) and its underlying molecular mechanism. RT-qPCR, western blot, flow cytometry (FCM), enzyme-linked immunosorbent assay (ELISA) were utilized for evaluating inflammation apoptosis. Next, RIP, RNA pull-down, dual-luciferase reporter gene assay, a series rescue experiments performed to explore regulatory mechanisms MK5-AS1 sponge-like action RA-FLSs. The...
This study examined the relationship of Sharp score with demographic factors and clinical immune-inflammatory markers in patients anemia rheumatoid arthritis (RA).The data 1057 RA 1006 without were retrospectively analyzed. Spearman's correlation coefficient analysis, association rule logistic regression used to relationships between influencing anemia.The incidence was 51.24% (1057/2063), mild accounted for 81.93% (866/1057) cases. analyses revealed that correlated response anemia. Logistic...
Ankylosing spondylitis (AS) has a high disability rate, and an early diagnosis is difficult.To explore the possible functions underlying mechanism of circular RNAs Homo sapiens (hsa)_circ_0003307 in ankylosing spondylitis.The hsa_circ_0003307 expression levels were investigated peripheral blood mononuclear cells (PBMCs) 30 AS patients healthy controls (HC) using quantitative reverse transcription polymerase chain reaction (qRT-PCR) analysis. Primary fibroblast-like synoviocytes (FLS)...
Rheumatoid arthritis (RA) is an autoimmune disease resulting in overall poor prognosis. Siegesbeckiae Herba a natural botanical herb that possesses variety of biological activities, particularly anti-rheumatism properties. This study collected the clinical data 7657 patients with RA who received treatment traditional Chinese medicine prescriptions before December 2021 Department Rheumatology, The First Affiliated Hospital Anhui University Traditional Medicine. levels immune-inflammatory...
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic systemic inflammation, leading to joint deformities and functional loss. RA progression accompanied abnormalities in the coagulation-fibrinolysis system, clinically manifested as a hypercoagulable state. However, there are currently no bibliometrics or visualization analysis this field.The present study aims reveal knowledge structure, research status, trends related hypercoagulability through bibliometric evaluate...
To investigate the effect of triptolide (TPL) on inflammatory response and migration fibroblast like synovial cells (FLS) in rheumatoid arthritis (RA-FLS) mechanism circular noncoding RNA (circRNA) 0003353 for mediating this effect.We collected peripheral blood mononuclear (PBMCs) serum samples from 50 hospitalized RA patients 30 healthy individuals detecting expression circRNA 0003353, immune indexes (ESR, CRP, RF, anti-CCP, IgA, IgG, IgM, C3, C4) DAS28 score. Cultured RA-FLS was treated...
Objective. This study aimed to analyze the effect of traditional Chinese medicine (TCM) on risk readmission for rheumatoid arthritis (RA) patients with anemia. Methods. In this study, 893 hospitalized RA were followed up by telephone. A retrospective cohort was conducted using propensity score matching (PSM). The Cox proportional hazards model used assess influence various factors Kaplan–Meier survival curve utilized TCM intervention time readmission. Results. incidence anemia 58.08%...
Objective: To explore the effect of Xinfeng Capsule (XFC) on hypercoagulable state in patients with rheumatoid arthritis (RA) using data mining and network pharmacology. Methods: The were collected 524 inpatients RA who treated XFC Department Rheumatology Immunology First Affiliated Hospital Anhui University traditional Chinese medicine (TCM) before October 2021. changes C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), factor (RF), complement component 3 (C3), C4, platelet...
Self-perception in patients is their self-response to sensory stimuli. It an important aspect of the existence and quality life among patients. However, inherent relationship between self-perception cellular activity at molecular level elusive. In this study, we aimed explore association with RNA expression profile rheumatoid arthritis (RA) through computational analysis. We recruited 30 clinically diagnosed RA age- sex-matched controls without previous clinical history. total, 5 measures...
To evaluate whether traditional Chinese medicine compound preparations (TCMCPs) are associated with rheumatoid arthritis- (RA-) related complications (including readmission, Sjogren's syndrome, surgical treatment, and all-cause death) in patients RA.Clinical outcome data were retrospectively collected from RA discharged the Department of Rheumatology Immunology First Affiliated Hospital Anhui University Medicine January 2009 to June 2021. The propensity score matching method was used match...