A5086144154- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Rheumatoid Arthritis Research and Therapies
- Cancer-related gene regulation
- Extracellular vesicles in disease
- Osteoarthritis Treatment and Mechanisms
- Peptidase Inhibition and Analysis
- Toxin Mechanisms and Immunotoxins
- Pharmacological Effects of Natural Compounds
- RNA Research and Splicing
- Natural product bioactivities and synthesis
- Galectins and Cancer Biology
- Traditional Chinese Medicine Analysis
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Bioactive Natural Diterpenoids Research
- Liver Disease Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Genetics and Neurodevelopmental Disorders
- Natural Compounds in Disease Treatment
- Liver physiology and pathology
- Receptor Mechanisms and Signaling
- Viral-associated cancers and disorders
Anhui University of Traditional Chinese Medicine
2021-2025
University of Hong Kong
2024-2025
Chinese University of Hong Kong
2024-2025
Anhui Science and Technology University
2012-2021
Anhui University of Science and Technology
2012-2021
Anhui Medical University
2012-2015
Vascular endothelial cells (VEC) play a key role in the occurrence and progression of vascular inflammation. VEC activation secretes powerful inflammatory mediators aggravates development rheumatoid arthritis (RA). Angiogenesis plays pathological processes inflammation synovial infiltration, driving RA progression. A substantial amount evidence suggests that at site is both an active participant regulator process. At present, research progress still incomplete. In this review, we summarize...
Context: Crocin, a diterpenoid glucoside, has multitudinous activities such as anti-inflammation, anti-allergy, anti-oxidation and relaxing smooth muscles.
The pathogenesis of rheumatoid arthritis (RA) is still not fully clarified, and the development therapeutic drugs for RA particularly urgent. Our group studies a possibility that circ_ 0015756/miR-942-5p may participate in through disordered Cullin 4B ( CUL4B ) traditional Chinese medicine compound Huangqin Qingre Chubi Capsule (HQC) inhibit /Wnt pathway. Data showed expression circ_0015756 increased only fibroblast-like synoviocytes (FLS) RA, but also synovium FLS CIA mice, miR-942-5p...
Our previous study found that Cullin 4B (CUL4B) inhibited rheumatoid arthritis (RA) pathology through glycogen synthase kinase-3beta (GSK3β)/canonical Wnt signalling pathway. In this work, pre-experiment and bioinformatics analysis suggested circ_0011058 may lead to the up-regulation of CUL4B expression by inhibiting miR-335-5p. Therefore, we studied whether can promote sponging miR-335-5p further pathological development RA. Bioinformatics prediction, real-time quantitative PCR (RT-qPCR),...