A5100369949- Intraocular Surgery and Lenses
- Corneal surgery and disorders
- Connexins and lens biology
- Ophthalmology and Visual Impairment Studies
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Gut microbiota and health
- Cardiac electrophysiology and arrhythmias
- Traditional Chinese Medicine Studies
- Retinal Imaging and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Cardiac Imaging and Diagnostics
- Retinal Diseases and Treatments
- Advanced MRI Techniques and Applications
- Ophthalmology and Eye Disorders
- Nicotinic Acetylcholine Receptors Study
- Liver Disease Diagnosis and Treatment
- Retinal and Macular Surgery
- Medical Research and Treatments
- Ocular and Laser Science Research
- Corneal Surgery and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Retinopathy of Prematurity Studies
- Receptor Mechanisms and Signaling
- Heme Oxygenase-1 and Carbon Monoxide
Yale University
2025
Beijing Chao-Yang Hospital
2024
Capital Medical University
2012-2024
First Affiliated Hospital of Soochow University
2010-2024
Chinese Center For Disease Control and Prevention
2018-2024
China Rehabilitation Research Center
2024
Soochow University
2010-2024
National Institute for Radiological Protection
2015-2024
Nanjing Forestry University
2024
Anhui University of Traditional Chinese Medicine
2024
The intestinal mucosal barrier (IMB) enables the intestine to provide adequate containment of luminal microorganisms and molecules while preserving ability absorb nutrients. In this study, we explored effect brain-derived neurotrophic factor (BDNF) on IMB function gut microbiota in mice. BDNF gene knock-out mice (the BDNF+/- group) wild-type BDNF+/+ were selected. these was analyzed by denaturing gradient gel electrophoresis (DGGE) assay. ultrastructure ileum colonic epithelium obtained from...
Abstract Objectives Both Diabetic retinopathy (DR) and Atherosclerosis (AS) are common complications in patients with diabetes, they share major pathophysiological similarities have a pathogenesis. Studies performed to date demonstrated that ferroptosis plays vital part the occurrence development of DR AS, but its mechanism two diseases remains poorly understood. Methods Chip data (GSE60436 GSE102485) AS chip (GSE100927 GSE57691) were obtained from Gene Expression Omnibus (GEO) database. The...
The objective of this study was to examine the correlation between gut microbiota and both age-related macular degeneration (AMD) glaucoma. Mendelian randomization studies were conducted utilizing data sourced from genome-wide association (GWAS) database for microbiome, AMD, Single nucleotide polymorphism (SNP) estimates summarized through five (MR) methods. We utilized Cochran’s Q statistic evaluate heterogeneity instrumental variables (IVs). Additionally, we employed a “leave-one-out”...
Retinal ganglion cells in the mammalian central nervous system fail to regenerate following injury, with capacity survive and regrow varying by cell type. This variability may be linked differences developmental programs that overlap genetic pathways mediate regeneration. To explore this correlation, we compared structural changes mouse retinal during development those occurring after axonal injury. The dendritic trees of over 1,000 were reconstructed at different stages, revealing each type...
Dendritic architecture plays a crucial role in shaping how neurons extract behaviorally relevant information from sensory inputs. Wide-field the superior colliculus integrate visual retina to encode cues critical for visually guided orienting behaviors. However, principles governing these filter their inputs generate appropriate responses remain unclear. Using viral tracing, two-photon calcium imaging, and computational modeling, we show that wide-field receive functionally diverse twelve...
It has been found that gap junction-associated intracellular Ca(2+) [Ca(2+)](i) disturbance contributes to the arrhythmogenesis and hyperconstriction in diseased heart. However, whether functional gaps are also involved regulation of normal signaling, particular basal activities, is unclear.Global local signaling permeability were monitored cultured neonatal rat ventricular myocytes (NRVMs) freshly isolated mouse by Fluo4/AM Lucifer yellow (LY), respectively. The results showed inhibition...
In developing biosimilar or biobetter products, comparability to the reference product is required claim similar integrity intended purpose. this work, an anti-CD20 monoclonal antibody developed using RNA interference decrease core fucosylation (RNAi-mediated) was comprehensively characterized by LC-MS and compared with commercially-available rituximab (MabThera (®) ). As anticipated, < 30% fucose found within RNAi-produced molecule (compared > 90% in rituximab), reduction resulting a...
Rhamnose and sTn antigen were co-conjugated to bovine serum albumin (BSA) for cancer vaccine development. The immune responses against have been significantly augmented with the involvement of Rha-specific antibodies enhance uptake.
With advancements in sustainable urban development, research on functional areas has garnered significant attention. In recent years, Point-of-Interest, with their large volume of information and ease acquisition, have been widely applied domains. However, scholars currently focus the identification areas, usually relying data from a single period, whereas prediction not yet well validated. Therefore, this study, we propose new method based several years POI to predict areas. Taking Nanjing...
The purpose of this study was to explore the effect artesunate on endotoxin-induced uveitis (EIU) in rats.EIU induced male Long-Evans rats by footpad injection lipopolysaccharide (LPS 200 μg 0.1 mL PBS; LPS-only group [LG]). PBS (0.1 mL), prednisolone (10 mg/kg [PG]), and three concentrations (1, 10, 100 mg/kg; groups A, B, C [AGA, AGB, AGC]; all PBS) were injected intravenously, respectively, 1 hour after LPS injection. Twenty-four hours injection, infiltrating cells protein concentration...
Nonalcoholic fatty liver disease (NAFLD) and occupational stress have been recognized as major public health concerns. We aimed to explore whether was associated with NAFLD in a police population. A total of 6559 male officers were recruited for this prospective study April 2007. Among them, 2367 eligible subjects participated follow-up from 2008 2011. diagnosed based on standard criteria. Occupational evaluated by Stress Inventory-Revised scores. The incidence 31.2% the entire police. After...
Regulator of G protein signaling (RGS) proteins act as GTPase-activating (GAPs) for Galpha subunits and negatively regulate protein-coupled receptor signaling. Using RGS5 gene-specific RT-PCR, we have identified a novel alternative splicing variant mRNA in human ocular tissues. The occurred at position +44 (GenBank NM_003617), spliced out 174 bp (+44 to +218 bp) the coding region, encoded an RGS5s with 108 amino acid N-terminal deletion. This study is first document gene. We therefore...
Inositol 1,4,5-trisphosphate receptor (IP3R) plays a pivotal role in the Ca2+ release process variety of cell types. Additionally, IP3R is distributed ventricular intercalated discs, but its function(s) this particular site remains unknown. Connexin (Cx43), predominant gap junction (GJ) protein myocardium, linked to several signaling pathways that regulate Cx43 properties by (de)phosphorylation on multiple residues. Here, we investigated regulatory cell-cell communication and mechanism(s)...
This study aimed to examine the differences of retinal oxygen saturation between paired eyes in anisometropia and further explore relation oxygenation myopia.This was an observational cross-sectional study, with 124 adults included. According interocular spherical equivalent (SE), individuals a difference ≥3.0 D belonged ΔSE ≥ 3.0 group, those ≥1.5 <3.0 group. The group contained 61, < 64. All were performed examinations oximetry, SE, axial length (AL), intraocular pressure, central corneal...
Purpose The objective of this study was to eliminate any ambiguity by examining the correlation between gut microbiota and both AMD glaucoma.
 Methods Mendelian randomization studies were conducted utilizing data sourced from GWAS database for microbiome, AMD, glaucoma. SNP estimates summarized through five MR methods. We utilized Cochran&#039;s Q statistic evaluate heterogeneity instrumental variables. Additionally, we employed a &quot;leave-one-out&quot; approach verify...
The apparent diffusion coefficient (ADC) from diffusion-weighted imaging (DWI) can quantify alterations in water diffusivity resulting microscopic structural changes amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD).To investigate the ADC value for aMCI AD using Brain Search (BS) software based on anatomical volumes of interest (AVOI).In total, 174 aged people were screened, 25 patients with AD, 26 aMCI, 18 normal controls (NCs) recruited. DWI was performed at 1.5 T a...
Epithelial to mesenchymal transition (EMT) serves important roles in tumor invasion, metastasis, formation of cancer initiating cells (CICs) and drug resistance. HLA‑F adjacent transcript 10 (FAT10) has been proposed as an oncogene bladder cancer. However, the functional contribution FAT10 EMT CICs remains unclear The present study reports that protein expression is upregulated cell lines, overexpression promotes UMUC‑3 cells. In addition, increased tissue was associated with shorter overall...
To study the distribution of posterior corneal astigmatism (PCA) and its influencing factors in Chinese patients before cataract surgery.A retrospective was conducted First Affiliated Hospital Soochow University, Suzhou, China. In all, this enrolled 121 eligible eyes patients. The astigmatism, aberrations Q value anterior, total cornea anterior segment parameters (ACD, CCT, WTW, ATA) were measured by Sirius System, AL Lenstar LS 900. Cataract diagnosed using slit-lamp examination.The mean...
AIM: To predict postoperative intraocular lens (IOL) position using the Sirius anterior segment analysis system and investigate effect of IOL type on refraction. METHODS: A total 97 patients (102 eyes) were enrolled in final analysis. An biometry measurement was performed preoperatively with Lenstar. The results predicted (PLP) power automatically calculated by software used instruments. Effective (ELP) measured manually 3mo postoperatively. Pearson’s correlation linear regression to...