Guifang Li

ORCID: 0000-0002-4623-2611
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Research Areas
  • Soil erosion and sediment transport
  • Fungal Biology and Applications
  • Hydrology and Sediment Transport Processes
  • Cancer Immunotherapy and Biomarkers
  • Mycorrhizal Fungi and Plant Interactions
  • Hydrology and Watershed Management Studies
  • Nosocomial Infections in ICU
  • Bariatric Surgery and Outcomes
  • Hematopoietic Stem Cell Transplantation
  • Hemoglobinopathies and Related Disorders
  • Sepsis Diagnosis and Treatment
  • Gastrointestinal Tumor Research and Treatment
  • Acute Myeloid Leukemia Research
  • Acute Lymphoblastic Leukemia research
  • Immune cells in cancer
  • Pharmacological Effects of Natural Compounds
  • Metabolism, Diabetes, and Cancer
  • Respiratory Support and Mechanisms
  • Pneumonia and Respiratory Infections
  • Diet and metabolism studies
  • Thyroid Disorders and Treatments
  • Epigenetics and DNA Methylation
  • Blood groups and transfusion
  • Lipoproteins and Cardiovascular Health
  • Aeolian processes and effects

Ningxia Medical University
2019-2025

Jiangnan University
2023-2024

Wuxi Fourth People's Hospital
2023-2024

Ningxia Medical University General Hospital
2019-2024

State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau
2023

University of Chinese Academy of Sciences
2013-2023

Institute of Soil and Water Conservation
2016-2023

Chinese Academy of Sciences
2023

Ministry of Water Resources of the People's Republic of China
2023

Shandong First Medical University
2022

Core Ideas Effects of inflow rate on the Mollisol erosion process were examined. Inflow effects soil loss dependent dominant pattern. When upslope was included, increased 12 to 1950 times. Different hydrodynamic parameters crucial for sheet and rill erosion. water from is an extremely important factor that influences downslope processes. Little information available concerning how affects processes in Chinese region, where a large amount runoff generated upslope. The purpose this study...

10.2136/sssaj2016.02.0025 article EN Soil Science Society of America Journal 2016-05-01

Abstract Background To decipher the root and microbial interaction, secondary metabolite accumulation in roots community’s succession model during plant’s growth period demands an in-depth investigation. However, till now, no comprehensive study is available on of endophytic fungi arbuscular mycorrhizal (AMF) with medicinal licorice plants effects AMF root. Results In current study, interaction between microbes 1–3 years old rhizospheric soil was investigated. Secondary metabolites content...

10.1186/s12870-021-02942-6 article EN cc-by BMC Plant Biology 2021-04-05

Early identification and prevention of ventilator-associated pneumonia (VAP) in patients with mechanical ventilation (MV) through reliable prediction model undergoing a rigorous standardized process is essential for clinical decision-making. This study aims to externally validate the VAP previously developed by tertiary hospital Northwestern China, using data from different time periods or hospitals, develop web-based calculator application evaluate model's performance generalizability. We...

10.1016/j.ijmedinf.2025.105910 article EN cc-by-nc International Journal of Medical Informatics 2025-04-06

Pathogens are capable of hijacking immune defense mechanisms, thereby creating a tolerogenic environment for hypermutated malignant cells that arise within the site infection. Immune checkpoint-oriented immunotherapies have shown considerable promise. Equally important, epigenetic reprogramming an immune-evasive phenotype activates system in synergistic manner can improve immunotherapy outcomes. These advances led to combinations epigenetic- and immune-based therapeutics. We previously...

10.1158/2326-6066.cir-18-0709 article EN Cancer Immunology Research 2019-07-26

Lung adenocarcinoma (LAD) is a human malignancy successfully treated with the tyrosine kinase inhibitor (TKI) gefitinib; however, enrichment of therapy resistant cancer stem cells (CSCs) in such patients assumed to be source treatment failure. Evaluation LAD cell populations TKI gefitinib identified unique aspects subpopulation tumor exhibiting stem-like properties and mitochondria-specific metabolic features along their reliance on sirtuin 1 (SIRT1) for survival advantage. This addiction...

10.1016/j.neo.2019.10.006 article EN cc-by-nc-nd Neoplasia 2019-11-23

Background Metabolic-associated fatty liver disease (MAFLD) has become a worldwide epidemic. Prolactin (PRL), pituitary hormone, been linked to MAFLD. As result, we set out look into the relationship between serum PRL and risk of MAFLD in patients with type 2 diabetes mellitus (T2DM). Methods A total 724 adults T2DM were enrolled categorized as non-MAFLD groups. Anthropometric data, biochemical parameters, levels collected. Liver steatosis fibrosis assessed using FibroScan. Patients...

10.3389/fendo.2022.815995 article EN cc-by Frontiers in Endocrinology 2022-02-11

Colorectal cancer (CRC) is characterized by poor responsiveness to immune evasion and immunotherapy. RNA 7-methylguanine (m7G) modification plays a key role in tumorigenesis. However, the mechanisms which m7G-modified metabolism affects tumor progression are not fully understood, nor contribution of CRC microenvironment. The expression levels Methyltransferase-like 1 (METTL1) m7G human tissues were determined. In this study, effect METTL1 on was evaluated, PKM mRNA confirmed, level PKM2...

10.1186/s12967-024-05991-1 article EN cc-by-nc-nd Journal of Translational Medicine 2024-12-31

α-Thalassemia (α-thal) is one of the most prevalent genetic diseases in world and especially frequent tropical subtropical regions, including South China. The aim this study was to investigate prevalence spectrum α-thal Guizhou Province as information unknown. A total 40 carriers were determined 1219 newborn umbilical cord blood samples by hemoglobin (Hb) electrophoresis combined with DNA analysis, which revealed that carrier rate 3.28%. One thousand forty-five individuals referred our...

10.3109/03630269.2015.1041037 article EN Hemoglobin 2015-07-04

To explore the application value of dynamic monitoring gastric residual volume (GRV) in achieving different target energy severe mechanical ventilation patients.

10.3760/cma.j.cn121430-20231008-00849 article EN PubMed 2024-02-01

OBJECTIVE To investigate the association between apolipoprotein E (apoE) gene polymorphism and dose for warfarin individual maintenance. METHODS The genotypes of 249 patients with treatment in maintenance doses were determined by PCR/DHPLC assay. compared among different genotypes. RESULTS In total patients, frequencies 2/e2, e2/e3, e2/e4, e3/e3, e3/e4, e4/e4 genotype 1.20%, 15.66%, 1.80%, 72.29%, 9.24%, 0.80%, respectively; allele e2, e3, e4 9.44%, 84.74%, 5.82%, respectively. group e2...

10.3969/j.issn.1672-7347.2011.03.004 article EN 2011-03-01

Aims To investigate the predictive value of baseline serum triglyceride (TG) levels for improvements metabolism after laparoscopic sleeve gastrectomy (LSG). Methods 112 obese patients [body mass index (BMI) ≥ 35 kg/m 2 ] underwent LSG and with complete information anthropometric metabolic parameters were divided into normal TG group (group A) high B), while A had ≤ 1.7 mmol/L, B > mmol/L. The post-operative changes (Δ) in between two groups compared. Results In whole cohort,...

10.3389/fendo.2021.633856 article EN cc-by Frontiers in Endocrinology 2021-02-22

To report on the result of thalassemia screening and genetic diagnosis for pregnant women from Guiyang region.Prenatal was carried out based erythrocyte parameters hemoglobin electrophoresis. Single-tube multiplex GAP-PCR PCR-reverse dot blot hybridization were performed suspected cases to identify common alpha- beta- mutations, direct sequencing used identifying rare mutations.Among 13 738 women, 1745 (12.70%) as thalassemia. In terms native place, provinces with highest screening-positive...

10.3760/cma.j.issn.1003-9406.2017.04.026 article EN PubMed 2017-08-10

Investigation of intra-arterial chemotherapy infusion and embolization combined with abdominal for advanced gastric cancer

10.3748/wjg.v4.isuppl2.76 article EN cc-by-nc World Journal of Gastroenterology 1998-01-01

Background and Objectives: We aimed to investigate the role of Wnt2 expression in colorectal cancer (CRC) prognosis evaluate its potential as a therapeutic target BRAF-mutated CRC. Materials Methods: Exactly 136 samples formalin-fixed paraffin-embedded CRC tissue specimens were obtained from patients who underwent surgical resection for The gene mutation status was detected using fluorescence PCR. immunohistochemistry. Survival curves with high BRAF mutations compared Kaplan–Meier method. A...

10.3390/medicina59061133 article EN cc-by Medicina 2023-06-12
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