A5055633288- Interprofessional Education and Collaboration
- Primary Care and Health Outcomes
- Chronic Disease Management Strategies
- Schizophrenia research and treatment
- Health Systems, Economic Evaluations, Quality of Life
- Geriatric Care and Nursing Homes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Policy Implementation Science
- Parkinson's Disease Mechanisms and Treatments
- Clinical practice guidelines implementation
- Healthcare Policy and Management
- Tryptophan and brain disorders
- Nerve injury and regeneration
- Nuclear Receptors and Signaling
- Alzheimer's disease research and treatments
- Autism Spectrum Disorder Research
- Diet and metabolism studies
- Intergenerational Family Dynamics and Caregiving
- Neuroscience and Neuropharmacology Research
- Adipokines, Inflammation, and Metabolic Diseases
- Bipolar Disorder and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Patient Satisfaction in Healthcare
- Emergency and Acute Care Studies
- Palliative Care and End-of-Life Issues
Changi General Hospital
2019-2025
Clinical Nutrition Research Centre
2025
SingHealth
2020-2024
St Andrews Community Hospital
2023
National University Health System
2012-2020
National University of Singapore
2012-2020
University Health System
2019-2020
Institute of Mental Health
2012-2019
Centre for Health Technology and Services Research
2018
Florey Institute of Neuroscience and Mental Health
2015
Cognitive decline in Alzheimer's disease (AD) involves pathological accumulation of synaptotoxic amyloid-beta (Abeta) oligomers and hyperphosphorylated tau. Because recent evidence indicates that glycogen synthase kinase 3beta (GSK3beta) activity regulates these neurotoxic pathways, we developed an AD therapeutic strategy to target GSK3beta. The the use copper-bis(thiosemicarbazonoto) complexes increase intracellular copper bioavailability inhibit GSK3beta through activation Akt signaling...
We have previously demonstrated that brief treatment of APP transgenic mice with metal ionophores (PBT2, Prana Biotechnology) rapidly and markedly improves learning memory. To understand the potential mechanisms action underlying this phenomenon we examined hippocampal dendritic spine density, levels key proteins involved in memory, young (4 months) old (14 female Tg2576 following (11 days) oral PBT2 (30 mg/kg/d). Transgenic exhibited deficits density compared to littermate controls were...
The abnormal accumulation of alpha-synuclein (α-syn) has been linked to a number neurodegenerative disorders, the most noteworthy which is Parkinson's disease. Alpha-synuclein itself not toxic and fulfills various physiological roles in central nervous system. However, specific types aggregates have shown be toxic, metals assembly these aggregates. In this paper, we characterized transgenic mouse that overexpresses A53T mutation human α-syn, specifically assessing cognition, motor...
Introduction The lack of understanding how complex integrated care programmes achieve their outcomes due to the acceptable methods leads difficulties in development, implementation, adaptation and scaling up similar interventions. In this study, we evaluate an network, National University Health System (NUHS) Regional (RHS), consisting acute hospitals, step down care, primary providers, social services community partners using a theory-driven realist evaluation approach. This study aims...
Objective This study aimed to identify barriers and facilitators surrounding the implementation of TDOCS from Community Health Workers (CHW)'s perspective before implementation. Methods A descriptive qualitative was conducted through semistructured interviews with a purposive sampling CHWs partner nursing homes home care teams. French framework outlining asynchronous oral teleconsultation adoption used develop topic guide for this study. Then, Consolidated Framework Implementation research...
Schizophrenia has been associated with an increased risk of cardiometabolic morbidity and mortality. Metabolic syndrome (MetS), a reliable predictor cardiovascular-related mortality, also shown to be more prevalent in patients schizophrenia. In this study, we investigated the prevalence MetS sample schizophrenia Singapore, potential factors it.One hundred 300 community controls were recruited. All subjects provided fasted venous blood measure high-density lipoprotein cholesterol (HDL-C),...
Integrated care that focuses on organising healthcare services around people and their communities rather than diseases is promoted as the strategy to overcome challenges associated with growing complexity in needs, demand for inadequate supply of due fragmentation provision services. While conceptually appears be simple, integrated made up multicomponent delivery strategies targeting various levels system while engaging stakeholders execution.We applied complex adaptive (CAS) perspective...
To cope with rising demand for healthcare services in Singapore, Regional Health Systems (RHS) comprising of health and social care providers across settings were set up to integrate service delivery. Tasked providing the western region, 2012, National University System (NUHS) – RHS developed a transitional program elderly patients complex needs who consumed high levels hospital resources. Through assessment, development personalized plans coordination, aimed to: (i) improve quality care,...
Increased nigral iron (Fe) is a cardinal feature of Parkinson's disease, as the accumulation aggregates comprising α-synuclein. We used wild-type mice and transgenic overexpressing human A53T mutation to α-synuclein examine influence increased Fe (days 10-17 postpartum) on parkinsonian development phenotype these animals (including abnormal levels deficits in both cell numbers locomotor activity), explore impact chelator clioquinol model. Both untreated Fe-loaded showed similar loss, though...
Abstract Background Accessibility to efficient and person-centered healthcare delivery drives transformation in many countries. In Singapore, specialist outpatient clinics (SOCs) are commonly congested due increasing demands for chronic care. To improve this situation, the National University Health System (NUHS) Regional (RHS) started an integrated care initiative,the Right-Site Care (RSC) program 2014. Through collaborations between SOCs at Hospital primary community (PCC) western region...
Immune-inflammatory mediators play a pivotal role in brain signaling and have been increasingly associated with the pathophysiology of schizophrenia. Many studies indicated an increased level immune-inflammatory interleukin-6 (IL-6) IL-6 is well-known chief stimulator inflammation. Of late leptin has also implicated inflammatory pathway In this study we measured compared serum levels patients schizophrenia to healthy controls, investigated relationship between leptin.
There is a growing interest in the association between schizophrenia and activation of inflammatory system with signs acute phase (AP) response. Majority such studies had focused on C-reactive protein (CRP). The aims present study were (i) to examine gene expression profiles other proteins (APP), namely haptoglobin (HP), alpha-1 antitrypsin (A1T), alpha-2 macroglobulin (A2M) patients first episode psychosis (FEP) over period three months (ii) explore APP levels severity symptoms.In this...
Background: Integrated care is an important strategy for improving the process and outcome of healthcare delivery patients with complex needs. Until now, there has been no universally accepted validated measurement tool integrated care. This study aimed to validate The Rainbow Model Care Measurement Tool (RMIC-MT) which assesses, using a self-administered questionnaire, micro level (clinical), meso (professional organisational), macro (system) enabling (functional normative) aspects...
Objective To evaluate the impact on healthcare utilisation frequencies and charges, mortality of a programme for frequent hospital utilisers patients requiring high acuity post-discharge care as part an integrated model. Design A retrospective quasi-experimental study without randomisation where who received interventions were matched 1:1 with unenrolled controls. Setting The National University Health System (NUHS) Regional (RHS), which was one six RHS in Singapore, implemented NUHS...
Recent meta-analyses of serum brain-derived neurotrophic factor (BDNF) have reported lower levels in patients with schizophrenia. However, most studies did not consider the potential confounding effects time collection, age, sex, smoking, and obesity. Here, we sought to examine differences BDNF between medicated schizophrenia compared control subjects, taking into consideration confounders BDNF. Serum was obtained from a sample fasted blood collected all participants, assayed on commercially...
Abstract Aims This study aims to examine and compare the predictive utility of blood pressure ( BP ), waist circumference WC ) body mass index BMI determine optimal cut‐off values in prediction metabolic syndrome M et S patients with chronic schizophrenia. Methods About 100 schizophrenia were recruited. measured laboratory tests evaluate patients’ high‐density lipoprotein cholesterol, triglycerides glucose levels performed. Presence was examined according AHA/NHLBI guidelines. Predictive ,...
Objectives The capability and capacity of the primary community care (PCC) sector for dementia in Singapore may be enhanced through better integration. Through a partnership involving tertiary hospital PCC providers, an integrated network (CARITAS: comprehensive, accessible, responsive, individualised, transdisciplinary, accountable seamless) was implemented. study evaluated process extent integration within CARITAS. Design Triangulation mixed-methods design analyses were employed to...