A5015478695- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Drug Transport and Resistance Mechanisms
- Autism Spectrum Disorder Research
- Genetic Associations and Epidemiology
- Bipolar Disorder and Treatment
- Mental Health and Psychiatry
- Pharmacogenetics and Drug Metabolism
- Mental Health Research Topics
- Functional Brain Connectivity Studies
- Machine Learning in Healthcare
- T-cell and B-cell Immunology
- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- Hematopoietic Stem Cell Transplantation
- Pharmacological Effects and Toxicity Studies
- Obsessive-Compulsive Spectrum Disorders
- HIV/AIDS drug development and treatment
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Vitamin D Research Studies
- Silymarin and Mushroom Poisoning
- GABA and Rice Research
- Molecular Biology Techniques and Applications
Institute of Mental Health
2016-2025
Nanyang Technological University
2024
PAX Scientific (United States)
2018
National University Health System
2016
National University of Singapore
2008-2015
University of Pennsylvania
2000
University of New Mexico
2000
Abstract Contemporary chemotherapeutic treatments incorporate the use of several agents in combination. However, selecting most appropriate drugs for such therapy is not necessarily an easy or straightforward task. Here, we describe a targeted approach that can facilitate reliable selection drug combinations through interrogation drug-resistance gene networks. Our method employed single-cell eukaryote fission yeast ( Schizosaccharomyces pombe ) as model proliferating cells to delineate...
Predictors of functioning are well-studied in schizophrenia, but much less so treatment-resistant schizophrenia (TRS). In this study, we aim to investigate contributions symptom domains and neurocognition predict a TRS population (n = 146).
Abstract Introduction: Treatment-resistant schizophrenia (TRS) affects around 30% of individuals with schizophrenia. About half the patients TRS who are treated clozapine do not show a meaningful clinical response, that is, resistance. To date, relationship between cognitive function and treatment response categories is entirely clear. This study evaluated performance across subgroups stratified by we hypothesised impairment increases increased Methods: was conducted at Institute Mental...
Total vitamin D levels had been commonly reported to be lowered in patients with chronic psychotic illnesses countries from the higher latitudes. However, studies on first episode psychosis (FEP) are limited. In this study we investigated serum concentrations of total and bioavailable FEP compared healthy controls association between symptom severity components. A 31 were recruited Institute Mental Health, Singapore. identified using Structured Clinical Interview for DSM-IV Axis I disorders...
In order to provide gene expression profiles of different cell types, the primary step is isolate specific cells interest via laser capture microdissection (LCM), followed by extraction good quality total RNA sufficient for quantitative real-time polymerase chain reaction (qPCR) analysis. This LCM-qPCR strategy has allowed numerous studies on populations, providing valuable insights into cellular changes in diseases. However, such imposed challenges as interests are often available limited...
The ultra-high risk (UHR) state was originally conceived to identify individuals at imminent of developing psychosis. Although recent studies have suggested that most designated UHR do not, they constitute a distinctive group, exhibiting cognitive and functional impairments alongside multiple psychiatric morbidities. characterization using molecular markers may improve understanding, provide novel insight into pathophysiology, perhaps psychosis prediction reliability. Whole-blood gene...
This study evaluated the pharmacokinetics of gabapentin in Chinese subjects who received a diet rich shiitake mushrooms. Shiitake mushrooms have been shown to contain high amount ergothioneine. In vitro studies that OCTN1-mediated secretion is trans-stimulated by also investigated concentrations ergothioneine plasma at baseline and following mushroom consumption.Ten healthy male were recruited containing no (treatment A) or B; after least 7 day washout period) 1 prior administration single...
There is a growing interest in the association between schizophrenia and activation of inflammatory system with signs acute phase (AP) response. Majority such studies had focused on C-reactive protein (CRP). The aims present study were (i) to examine gene expression profiles other proteins (APP), namely haptoglobin (HP), alpha-1 antitrypsin (A1T), alpha-2 macroglobulin (A2M) patients first episode psychosis (FEP) over period three months (ii) explore APP levels severity symptoms.In this...
Background: Clozapine is the drug of choice indicated for treatment-resistant schizophrenia (TRS), but delays in initiation and underutilization might have affected its effectiveness practice. In this study, we sought to examine clinical outcomes patients on clozapine treatment if a delay was associated with poorer outcomes.Methods: This study conducted at tertiary mental health institution aged 21 80 years from January 2016 October 2019 who were stable dose 2 weeks. All assessed using...
Immune dysfunction has been proposed to play a role in the pathophysiology behind development and persistence of psychosis. Current immunophenotyping studies are limited by small sample sizes number immune markers investigated. Pharmacological subtypes schizophrenia based on antipsychotic response have proposed, but few investigated immunophenotypes treatment-resistant schizophrenia. In this study, we perform comprehensive 196 subjects comprising 147 patients stratified (49...
The essential role of the Reelin gene (RELN) during brain development makes it a prominent candidate in human epigenetic studies Schizophrenia. Previous literature has reported differing levels DNA methylation (DNAm) patients with psychosis. Therefore, this study aimed to (1) examine and compare RELN DNAm subjects at different stages psychosis cross-sectionally, (2) analyse effect antipsychotics (AP) on DNAm, (3) evaluate effectiveness applicability promoter as possible biological-based...
Identifying biomarkers to enrich prognostication and risk predictions in individuals at high of developing psychosis will enable stratified early intervention efforts. Brain-derived neurotrophic factor has been widely studied schizophrenia first-episode with promising results. The aim this study was examine the levels serum brain-derived between healthy controls ultra-high psychosis. A sample 106 105 from Longitudinal Youth Risk Study included study. Ultra-high status determined using...
γ-Aminobutyric acid (GABA), the primary inhibitory neurotransmitter, has often been studied in relation to its role pathophysiology of schizophrenia. GABA is synthesized from glutamate by glutamic decarboxylase (GAD), derived two genes, GAD1 and GAD2. expressed as both GAD67 GAD25 mRNA transcripts with former reported have a lower expression level schizophrenia compared healthy controls latter was be predominantly fetally, suggesting developmental process. In this study, levels were measured...
Biomarkers identified for psychosis might allow early diagnosis, more accurate prognosis, and tailored individualized interventions. Brain-derived neurotrophic factor (BDNF) is suggested to be a likely candidate biomarker the diagnosis treatment evaluation in psychosis. The aims of present study were examine levels serum BDNF both patients with first-episode (FEP) healthy controls year, investigate association between symptom severity remission status.A sample 31 29 FEP included this study....
Sequence‐specific oligonucleotide probe hybridization and sequence‐specific primer polymerase chain reaction (PCR) typing suggested the presence of variants HLA‐B*40 in three individuals. Two were part 3,500 potential marrow donors being screened for National Marrow Donor Program, while third was a clinical specimen. PCR products encompassing HLA‐B locus exons 1 through 3 prepared subcloned. In one individual, native Pacific Islands, sequencing revealed novel allele (B*4023). two other...
<title>Abstract</title> Background In this research study, we apply machine learning techniques to navigate the multifaceted landscape of schizophrenia. Our method entails development predictive models, emphasizing peripheral inflammatory biomarkers, which are classified into treatment response subgroups: antipsychotic-responsive, clozapine-responsive, and clozapine-resistant. Methods The study comprises 146 schizophrenia patients (49 antipsychotics-responsive, 68 29 clozapine-resistant) 49...