A5016877156- Schizophrenia research and treatment
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Functional Brain Connectivity Studies
- Mental Health and Psychiatry
- Mental Health Treatment and Access
- Grit, Self-Efficacy, and Motivation
- Tryptophan and brain disorders
- Family Caregiving in Mental Illness
- Resilience and Mental Health
- Psychosomatic Disorders and Their Treatments
- Child and Adolescent Health
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Bipolar Disorder and Treatment
- Healthcare Education and Workforce Issues
- Stress Responses and Cortisol
- Single-cell and spatial transcriptomics
- Cystic Fibrosis Research Advances
- Memory and Neural Mechanisms
- Obsessive-Compulsive Spectrum Disorders
- Neuroendocrine regulation and behavior
- Genetic Associations and Epidemiology
- Heterotopic Ossification and Related Conditions
- Healthcare professionals’ stress and burnout
- Health, Environment, Cognitive Aging
Institute of Mental Health
2013-2022
Duke-NUS Medical School
2013-2021
Duke University
2017-2020
National University of Singapore
2013-2016
Fondazione Santa Lucia
2007
University of Milano-Bicocca
2007
Burnout is a serious issue plaguing the medical profession with potential negative consequences on patient care. symptoms are observed as early school. Based Job Demands-Resources model, this study aims to assess associations between specific job resources measured at beginning of first year school burnout occurring later in year.
<h3>Importance</h3> Cognitive deficits are a key feature of risk for psychosis. Longitudinal changes in cognitive architecture may be associated with the social and occupational functioning young people. <h3>Objectives</h3> To examine longitudinal profiles cognition individuals at ultrahigh (UHR) psychosis, compared healthy controls, to investigate association functioning. <h3>Design, Setting, Participants</h3> This study has multiple-group prospective design completed 24 months was...
Cognitive deficits are prevalent in people with schizophrenia and associated functional impairments. In addition to antipsychotics, pharmacotherapy often includes other psychotropics, some of these agents possess anticholinergic properties, which may impair cognition. The objective this study was explore the association between medication burden cognition schizophrenia.Seven hundred five individuals completed a neuropsychological battery comprising Judgment Line Orientation Test, Wechsler...
Negative symptoms and cognitive deficits in schizophrenia are partially overlapping. However, the nature of relationship between negative cognition remains equivocal. Recent reviews have demonstrated presence two symptom subdomains, diminished emotional expression (DEE) avolition. In view this, we sought to clarify domains.A total 687 participants with were assessed on measures psychopathology cognition. Three factors, namely executive function, fluency/memory speed/vigilance computed from...
The complex interplay of education, age, and cognitive performance on various neuropsychological tests is examined in the current study. New education indices were formulated further investigated to reveal how age variances work together account for tests. Participants 830 English-speaking ethnic Chinese. Neuropsychological measures such as Verbal Memory, Digit Sequencing, Token Motor Task, Semantic Fluency, Symbol Coding, Tower London, Judgment Line Orientation, Matrix Reasoning Wechsler...
Aim Recent studies have highlighted that attenuated psychotic symptoms ( APS ) are an important source of distress in ultra high risk UHR individuals and this is related to transition psychosis TTP ). This study examined associated with investigated its association . Methods The Comprehensive Assessment At‐Risk Mental State CAARMS was used identify 173 individuals, who were included as participants the study. Distress self‐reported. Functioning assessed on Social Occupational Scale....
Background. Elucidating the cognitive architecture of schizophrenia promises to advance understanding clinical and biological substrates illness. Traditional cross-sectional neuropsychological approaches differentiate impaired from normal abilities but are limited in their ability determine latent substructure. The current study examined abnormal cognition via a systematic approach. Method. Exploratory factor analysis (EFA) confirmatory (CFA) were carried out on large dataset including Brief...
The MATRICS Consensus Cognitive Battery (MCCB) was developed to provide a reliable, valid, and standard battery for clinical trials on cognitive enhancers in schizophrenia. In this study we tested the applicability of MCCB Singapore's English speakers. Healthy ethnic Chinese, Malay, Indian speakers (N = 171) both genders were recruited within three age groups levels education match as closely possible US norming sample, administered MCCB. Descriptive data, T scores, age, gender, education,...
There is a dearth of non-Western normative data for neuropsychological batteries designed to measure cognitive deficits in schizophrenia. Here, we provide English-speaking ethnic Chinese on the widely used Brief Assessment Cognition Schizophrenia acquired from 595 healthy community participants between ages 14 and 55. Means standard deviations subtests composite scores were stratified by age group sex. We also explored linear regression approaches generate continuous norms adjusted age, sex,...
The study aims to identify and validate a parsimonious subset of tests in the commonly used Brief Assessment Cognition Schizophrenia (BACS) that allows evaluation global cognitive ability. Several permutations subtests from BACS were examined best compose short form measure. Cognition-Short Form (BAC-SF) was evaluated for convergent validity healthy psychiatric samples (N = 3718). Verbal Memory, Digit Sequencing, Symbol Coding found summarize variance composite scores both Asian US Norming...
The addition of off-the-shelf cognitive measures to established prodromal criteria has resulted in limited improvement the prediction conversion psychosis. Tests that assess processes central schizophrenia might better identify those at highest risk. latent inhibition paradigm assesses a subject's tendency ignore irrelevant stimuli, process integral healthy perceptual and function been hypothesized be key deficit underlying development schizophrenia. In this study, 142 young people ultra...
The essential role of the Reelin gene (RELN) during brain development makes it a prominent candidate in human epigenetic studies Schizophrenia. Previous literature has reported differing levels DNA methylation (DNAm) patients with psychosis. Therefore, this study aimed to (1) examine and compare RELN DNAm subjects at different stages psychosis cross-sectionally, (2) analyse effect antipsychotics (AP) on DNAm, (3) evaluate effectiveness applicability promoter as possible biological-based...
Abstract Background Burnout is a serious issue plaguing the medical profession with potential negative consequences on patient care. symptoms are observed as early school. Based Job Demands-Resources model, this study aims to assess associations between specific job resources measured at beginning of first year school burnout occurring later in year. Methods The grit, tolerance for ambiguity, social support and gender were Duke-NUS Medical School students start Year 1. Students then surveyed...
A child's parental bonding, measured using the Parental Bonding Instrument (PBI), has been found to be associated with psychiatric illnesses. In particular, a significantly higher proportion of patients schizophrenia tend report affectionless-controlling mothers as compared healthy controls. This study aims (i) investigate applicability PBI tool in Singapore, exploratory factor analysis, and (ii) explore association between symptom severity functioning across patients, individuals at...