A5102152986- Ear Surgery and Otitis Media
- Vestibular and auditory disorders
- Facial Nerve Paralysis Treatment and Research
- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Ear and Head Tumors
- Voice and Speech Disorders
- Infection Control and Ventilation
- Cerebrospinal fluid and hydrocephalus
- Nasal Surgery and Airway Studies
- Head and Neck Surgical Oncology
- Noise Effects and Management
- CRISPR and Genetic Engineering
- Meningioma and schwannoma management
- Facial Rejuvenation and Surgery Techniques
- Respiratory viral infections research
- Pluripotent Stem Cells Research
- Reconstructive Facial Surgery Techniques
- Neurosurgical Procedures and Complications
- Digital Transformation in Industry
- Spatial Neglect and Hemispheric Dysfunction
- Plant tissue culture and regeneration
- Semiconductor materials and devices
- Liver Disease and Transplantation
- Neutropenia and Cancer Infections
Duke-NUS Medical School
2023-2025
Singapore General Hospital
2015-2025
SingHealth Duke-NUS Academic Medical Centre
2016-2024
Sir Charles Gairdner Hospital
2022-2024
Changi General Hospital
2014-2018
Zero to Three
2018
SingHealth
2014
Genome Institute of Singapore
2013
National University of Singapore
2005-2013
Micron (Singapore)
2012
ABSTRACT Background There are reports about the changing epidemiology of tongue squamous cell carcinoma (SCC), with recent indicating an increasing incidence in young women. Methods Data on incident cases SCC were collected from cancer registries worldwide. Results a total 22 and 89,212 worldwide included. Most areas experienced increase ranging 0.4% to 3.3% per year. was significant difference between sexes 11 registries. In 14 studied, higher group subjects <45 years old than those ≥45...
Embryonic stem cell (ESC) pluripotency is governed by a gene regulatory network centered on the transcription factors Oct4 and Nanog. To date, robust self-renewing ESC states have only been obtained through chemical inhibition of signaling pathways or enforced transgene expression. Here, we show that ESCs with reduced expression resulting from heterozygosity also exhibit stabilized pluripotent state. Despite having expression, Oct4+/− increased genome-wide binding Oct4, particularly at...
Objectives/Hypothesis The severity of Bell's facial palsy is monitored through physician‐graded instruments, like the House‐Brackmann or Sunnybrook Facial Grading System (FGS). These instruments primarily measure degree muscle impairment and its resulting asymmetry, but neglect other functional aspects disability. aim this study therefore to compare FGS with a patient‐graded quality‐of‐life (QOL) instrument, Clinimetric Evaluation Scale (FaCE). Study Design Prospective longitudinal study....
Importance Falls constitute a significant public health concern worldwide and have been associated with increased morbidity mortality across all ages. Identifying potentially modifiable risk factors for falls is key priority. Literature surrounding the association between hearing loss (HL) remains inconclusive. Objective To conduct systematic review meta-analysis to comprehensively synthesize evidence impact of HL on falls. Data Sources PubMed, Embase, Cochrane Library from database...
Objective The degree of pneumatization the temporal bone has implications in pathophysiology and surgical considerations many disorders. This study aims to identify common patterns petrous apex, mastoid, infralabyrinthine compartments bone. Variables associated with were also identified. Study Design Case series chart review. Setting Single tertiary hospital. Subjects Methods In total, 299 high‐resolution computed tomography scans performed on patients between 2013 2016 reviewed. Only normal...
Objective Dysphonia has been linked to psychosocial factors such as anxiety and personality type. The aim of this study is determine whether these also affect the treatment outcome benign dysphonia. Study Design Prospective case series. Setting Voice clinic a tertiary otolaryngology clinic. Subjects Methods Thirty‐seven patients diagnosed with dysphonia over 3‐month period were included. Demographic data, Handicap Index–10 (VHI‐10), Reflux Symptom Index (RSI), Clinical Anxiety Scale (CAS),...
Febrile neutropenia (FN) is a dose-limiting complication of chemotherapy. Judicious usage prophylactic granulocyte-colony-stimulating factors, such as pegfilgrastim, can prevent the occurrence FN. Although studies have been conducted to evaluate effectiveness pegfilgrastim FN in lymphoma patients receiving myelosuppressive chemotherapy, limited data available identify who are at risk developing despite primary prophylaxis with (breakthrough FN).The aim this study to: (1) clinical...
Abstract Background To determine the prevalence, risk factors; and impact on patient health economic outcomes across laterality spectrum of multiple sensory impairment (MSI) in a multi-ethnic older Asian population. Methods In this population-based study Singaporeans aged ≥ 60 years, MSI was defined as concomitant vision (visual acuity > 0.3 logMAR), hearing (pure-tone air conduction average 25 dB), olfactory (score < 12 Sniffin’ Sticks test) impairments (any, unilateral, combination...
Objective To investigate the safety and feasibility of precise delivery a long-acting gel formulation containing 6% dexamethasone (SPT-2101) to round window membrane for treatment Menière's disease Study Design Prospective, unblinded, cohort study Setting Tertiary care neurotology clinic Patients Adults 18 85 years with diagnosis unilateral definite Menière’s per Barany society criteria Intervention(s) A single injection under direct visualization into niche Main Outcome Measure(s) Procedure...
Cochlear implant surgery is performed commonly through the facial recess via round window (RW) approach. This study aims to evaluate utility of reformatting pre-operative CT temporal bone scan into a view in alerting surgeons potentially difficult with poorly visualized window.
Oxaliplatin is a cytotoxic platinum compound that in widespread use the treatment of gastrointestinal cancers. It has been occasionally associated with acute motor neuropathy, but precise mechanism uncertain. To best our knowledge, we report first case patient demonstrating post-tetanic facilitation setting transient bilateral abducens neuropathy and hypokalemia, after being infused oxaliplatin. A 47-year-old Indian woman metastatic gastric cancer was receiving an oxaliplatin infusion at...
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CMP non-uniformity has been an increasingly critical issue that needs to be addressed as memory device geometries continue shrink. This is more prominent for ILD oxide due its poor controllability compared other processes can rely on stopping layers effective endpoint detections and control. In this paper, we propose a novel approach address the by introducing dual film polish concept. Experimental results show improves wafer reduces scratches. Final probe yield suggests valid. A rate model...
There is a lack of evidence-based guidelines with regard to eye protection for aerosol-generating procedures in otolaryngology practice. In addition, some recommended personal protective equipment (PPE) not compatible commonly used ENT equipment. This study aims investigate the degree that PPE gives.Simulation model.Simulation laboratory.A custom-built setup was utilized simulate clinical scenario patient cough proximity health care worker. A system sprays xanthan-fluorescein mixture set up...
Abstract Background and Objectives To determine the impact of hearing impairment (HI) on health indicators in a multiethnic Singaporean population older adults. Research Design Methods In this cross-sectional, population-based study, pure-tone averages air-conduction thresholds at 500 Hz, 1,000 2,000 4,000 Hz were calculated for each ear. Eight categories HI defined ranging from: 1: No to 8: Bilateral severe HI. Health included hearing-related quality life (H-QoL), depressive symptoms,...
BACKGROUND: Spontaneous cerebrospinal fluid (CSF) leaks of the temporal bone occur in absence known iatrogenic or traumatic injury and without underlying congenital malformation. Holistic treatment condition requires meticulous perioperative evaluation patient to mitigate risk factors. Similarly, surgery for CSF careful consideration all potential routes leakage improve short- long-term surgical outcomes. OBJECTIVE: To describe our technique this article, which addresses most spontaneous...
Tele-medical systems have proven to be very useful improve patient outcomes. However, they suffered from drawbacks such as insufficient functionality, prohibitive cost, the lack of connectivity and many other factors. To solve these problems, medical experts were consulted an embedded tele-medical system was developed that allows a doctor analyze predict ailment direct paramedic on scene perform potentially life-saving corrective actions or even promote recovery. The would capture, process...
A Cost-effective Solution to Limit Aerosol Transmission of Infectious Agents During Mastoid Drilling—Reply